PATULIN

Product Name: PATULIN
CAS No.: 149-29-1
Chemical Name: PATULIN
Synonyms: PAT;mycoin;Terinin;CLAVACIN;clavatin;expansin;patuline;expansine;penicidin;clairformin
CBNumber: CB5780754
Molecular Formula: C7H6O4
Formula Weight: 154.12
MOL File: 149-29-1.mol

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PATULIN Property

Melting point:: 108-111 °C
alpha: D21 -6.2° (chloroform)
Boiling point:: 197.46°C (rough estimate)
Density: 1.1993 (rough estimate)
refractive index: 1.4300 (estimate)
Flash point:: 2℃
storage temp.: −20°C
solubility: ethyl acetate: soluble50mg/mL
form: Crystals or Crystalline Powder
pka: 11.69±0.20(Predicted)
color: White
Merck: 13,7125
BRN: 149675
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
CAS DataBase Reference: 149-29-1(CAS DataBase Reference)
IARC: 3 (Vol. 40, Sup 7) 1987
EPA Substance Registry System: Patulin (149-29-1)

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Safety

Hazard Codes: T,Xn,C,F
Risk Statements: 25-38-48/20/22-40-22-34-11-36-20/21/22-67-36/38-20-63
Safety Statements: 45-36/37-36/37/39-26-16
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: LV2625000
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 29419090
Hazardous Substances Data: 149-29-1(Hazardous Substances Data)
Toxicity: LD50 s.c. in mice: 10-15 mg/kg (Kinosita, Shikata)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CRM46914
Product name: Patulin solution
Purity: certifiedreferencematerial,100?μg/mLinchloroform,ampuleof1?mL
Packaging: 1mL
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: 34127
Product name: Patulin solution
Purity: 100μg/mL in acetonitrile, analytical standard
Packaging: 2ml
Price: $683
Updated: 2024/03/01

Sigma-Aldrich

Product number: 32759
Product name: Patulin
Purity: reference material
Packaging: 5mg
Price: $806
Updated: 2022/05/15

Cayman Chemical

Product number: 11346
Product name: Patulin
Purity: ≥98%
Packaging: 5mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 11346
Product name: Patulin
Purity: ≥98%
Packaging: 10mg
Price: $135
Updated: 2024/03/01

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PATULIN Chemical Properties,Usage,Production

Description

Spergillus and Penicillium species. Patulin is also an animal carcinogen, inhibits K1-uptake into erythrocytes, and inhibits various forms of Na1/K1-ATPase.

Chemical Properties

white crystals or fine crystalline powder

Uses

An inhibitor of protein prenylation

Uses

Patulin (PAT), a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products.

Definition

ChEBI: A furopyran and lactone that is 2H-pyran-3(6H)-ylidene)acetic acid which is syubstituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give he corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.

Purification Methods

Crystallise patulin from *C6H6, Et2O, EtOH or chloroform. It sublimes at 90o/high vacuum [Bergel et al. J Chem Soc 415 1944]. [Beilstein 18 III/IV 1184, 18/3 V 5.] (Highly TOXIC).

References

1) Jin et al. (2016), p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation; Sci. Rep., 6 24455 2) Zouaoui et al. (2016), Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells; Food Chem. Toxicol., 89 92 3) Boussabbeh et al. (2016), Tissue oxidative stress induced by patulin and protective effect of crocin; Neurotoxicology, 53 343 4) Pillay et al. (2015), Patulin triggers NRF2-meditated survival mechanisms in kidney cells; Toxicon, 99 1 5) Boussabbeh et al. (2015), Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway; Toxicol. Sci., 144 328

PATULIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PATULIN Suppliers

Belgium 1 Canada 1 China 116 Europe 1 France 1 Germany 5 India 4 Japan 2 Norway 1 Switzerland 3 United Kingdom 9 United States 22 USA 1 Global 167

Qingdao IniKem BioPharmaTech Co.,Ltd

Tel: 18561687109
Fax: -
Email: sales@inikem.com
Country: China
ProdList: 289
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4941
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9725
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17779
Advantage: 75

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View Lastest Price from PATULIN manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Patulin 149-29-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: PATULIN 149-29-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Dideu Industries Group Limited

Product: PATULIN 149-29-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-06-23

149-29-1, PATULINRelated Search:

CIS-2-PENTEN-1-OL VINYL FORMATE Vinyl acetate Allyl ether Ethyl propenyl ether 2-Methylene-1,3-propanediol 2,5-Dihydrofuran Ethyl vinyl ether Isopropenyl acetate 4-METHYL-2(5H)-FURANONE Vinyl crotonate 2(5H)-Furanone VINYL ACRYLATE 5-methylenefuran-2(5H)-one 2-Ethoxypropene 3-Methyl-2-buten-1-ol 3,3-Dimethylacrylic acid ALLYL VINYL ETHER

(2,4-dihydroxy-2h-pyran-3(6h)-ylidene)aceticacid-3,4-lactone

2,4-dihydroxy-2h-pyran-delta-3(6h),alpha-aceticacid-3,4-lactone

N-HEXADECANOYLTRYPTAMINE

PALMITIC ACID TRYPTAMIDE

PATULIN

PATULIN, PENICILLIUM EXPANSUM

PAT

N-[2-(3-INDOLYL)ETHYL]HEXADECANAMIDE

HEXADECANOIC ACID TRYPTAMIDE

CLAVACIN

4H-Furo3,2-cpyran-2(6H)-one, 4-hydroxy-

4-HYDROXY-4H-FURO[3,2-C]PYRAN-2(6H)-ONE

4,6-dihydro-4-hydroxy-2H-furo[3,2-c]pyran-2-one

Patulin,99%

Patulin4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one

Patulin ,98%

PATULINPURE

4-HYDROXY-FURO(3,2-C)PYRAN-2-ONE

Clavacin, Claviformin, Mycoin C3

Patulin from Penicillium expansum

4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one, PAT

2-c)pyran-2(6h)-one,4-hydroxy-4h-furo(

2h-pyran-delta(sup3(6h),alpha)-aceticacid,2,4-dihydroxy-,3,4-lactone

3-c)pyran-2(6h)-one,4-hydroxy-4h-furo(

aceticacid,(2,4-dihydroxy-2h-pyran-3(6h)-ylidene)-,3,4-lactone

clairformin

clavatin

claviform

claviformin

expansin

expansine

gigantin

leucopin

mycoin

mycoinc

mycoinc3

mycoinec3

mycosin

patuline

penatin

penicidin

tercinin

NSC 32951

NSC 8120

Terinin

Patulin solution, 99%, reference material

Standard Solution Patulin

Patulin Solution (100μg/ml Acetonitrile Solution)

PatulinSolution,100mg/L,1ml

Patulin 100ug/ml in ACN

Patulin Solution in Acetonitrile, 100μg/mL

Patulin Solution in Acetonitrile, 10μg/mL

PATULIN USP/EP/BP

Patulin-Patulin

4-Hydroxy-4,6-dihydro-2H-furo[3,2-c]pyran-2-one

149-29-1

Antibiotics N-S

Antibiotics