PATULIN
- Product Name
- PATULIN
- CAS No.
- 149-29-1
- Chemical Name
- PATULIN
- Synonyms
- PAT;mycoin;Terinin;CLAVACIN;clavatin;expansin;patuline;expansine;penicidin;clairformin
- CBNumber
- CB5780754
- Molecular Formula
- C7H6O4
- Formula Weight
- 154.12
- MOL File
- 149-29-1.mol
PATULIN Property
- Melting point:
- 108-111 °C
- alpha
- D21 -6.2° (chloroform)
- Boiling point:
- 197.46°C (rough estimate)
- Density
- 1.1993 (rough estimate)
- refractive index
- 1.4300 (estimate)
- Flash point:
- 2℃
- storage temp.
- −20°C
- solubility
- ethyl acetate: soluble50mg/mL
- form
- Crystals or Crystalline Powder
- pka
- 11.69±0.20(Predicted)
- color
- White
- Merck
- 13,7125
- BRN
- 149675
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- CAS DataBase Reference
- 149-29-1(CAS DataBase Reference)
- IARC
- 3 (Vol. 40, Sup 7) 1987
- EPA Substance Registry System
- Patulin (149-29-1)
Safety
- Hazard Codes
- T,Xn,C,F
- Risk Statements
- 25-38-48/20/22-40-22-34-11-36-20/21/22-67-36/38-20-63
- Safety Statements
- 45-36/37-36/37/39-26-16
- RIDADR
- UN 3462 6.1/PG 2
- WGK Germany
- 3
- RTECS
- LV2625000
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 29419090
- Hazardous Substances Data
- 149-29-1(Hazardous Substances Data)
- Toxicity
- LD50 s.c. in mice: 10-15 mg/kg (Kinosita, Shikata)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H315Causes skin irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CRM46914
- Product name
- Patulin solution
- Purity
- certifiedreferencematerial,100?μg/mLinchloroform,ampuleof1?mL
- Packaging
- 1mL
- Price
- $134
- Updated
- 2024/03/01
- Product number
- 34127
- Product name
- Patulin solution
- Purity
- 100μg/mL in acetonitrile, analytical standard
- Packaging
- 2ml
- Price
- $683
- Updated
- 2024/03/01
- Product number
- 32759
- Product name
- Patulin
- Purity
- reference material
- Packaging
- 5mg
- Price
- $806
- Updated
- 2022/05/15
- Product number
- 11346
- Product name
- Patulin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 11346
- Product name
- Patulin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $135
- Updated
- 2024/03/01
PATULIN Chemical Properties,Usage,Production
Description
Spergillus and Penicillium species. Patulin is also an animal carcinogen, inhibits K1-uptake into erythrocytes, and inhibits various forms of Na1/K1-ATPase.
Chemical Properties
white crystals or fine crystalline powder
Uses
An inhibitor of protein prenylation
Uses
Patulin (PAT), a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products.
Definition
ChEBI: A furopyran and lactone that is 2H-pyran-3(6H)-ylidene)acetic acid which is syubstituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give he corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.
Purification Methods
Crystallise patulin from *C6H6, Et2O, EtOH or chloroform. It sublimes at 90o/high vacuum [Bergel et al. J Chem Soc 415 1944]. [Beilstein 18 III/IV 1184, 18/3 V 5.] (Highly TOXIC).
References
1) Jin et al. (2016), p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation; Sci. Rep., 6 24455 2) Zouaoui et al. (2016), Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells; Food Chem. Toxicol., 89 92 3) Boussabbeh et al. (2016), Tissue oxidative stress induced by patulin and protective effect of crocin; Neurotoxicology, 53 343 4) Pillay et al. (2015), Patulin triggers NRF2-meditated survival mechanisms in kidney cells; Toxicon, 99 1 5) Boussabbeh et al. (2015), Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway; Toxicol. Sci., 144 328
PATULIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PATULIN manufacturers
- Product
- PATULIN 149-29-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27