BRL 54443
- Product Name
- BRL 54443
- CAS No.
- 57477-39-1
- Chemical Name
- BRL 54443
- Synonyms
- CS-1781;BRL 54443;BRL 54443 HCl;BRL 54443, >=98%;BRL-54443;BRL54443;BRL 54443 USP/EP/BP;BRL54443;BRL 54443;BRL-54443;3-(1-methylpiperidin-4-yl)-1H-indol-5-ol;3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol;1H-Indol-5-ol, 3-(1-Methyl-4-piperidinyl)-
- CBNumber
- CB2690838
- Molecular Formula
- C14H18N2O
- Formula Weight
- 230.31
- MOL File
- Mol file
BRL 54443 Property
- Boiling point:
- 431.5±45.0 °C(Predicted)
- Density
- 1.196
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- H2O: 50 mg/mL
- form
- solid
- pka
- 10.08±0.40(Predicted)
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21263
- Product name
- BRL 54443
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 21263
- Product name
- BRL 54443
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 21263
- Product name
- BRL 54443
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 21263
- Product name
- BRL 54443
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- 1129
- Product name
- BRL54443
- Packaging
- 50
- Price
- $495
- Updated
- 2021/12/16
BRL 54443 Chemical Properties,Usage,Production
Uses
BRL-53443 is a potent 5-HT and dopamine receptor agonist. Neuroresearch product.
Definition
ChEBI: 3-(1-methyl-4-piperidinyl)-1H-indol-5-ol is a member of hydroxyindoles.
Biological Activity
A potent 5-ht 1E/1F receptor agonist (pEC 50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pK i values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT 1E , 1F , 1A , 1B , 1D , 2A , 2B , 2C , 4 , 7 , D 2 and D 3 receptors respectively). Induces 5-HT 2A receptor-mediated mouse aortic contraction in vitro (pEC 50 = 6.52). Active in vivo .
storage
+4°C (desiccate)
References
1. a.m. brown, k. avenell, t j. young et al. brl 54443, a potent agonist with selectivity for human cloned 5-ht1e and 5-ht1f receptors. 1998. br.j.pharmacol. 123 233p.2. s. lightowler, t. stean, n. upton et al. effect of brl 54443 (3-(1-methylpiperidin-4-yl)-1h-indol-5-ol), a 5-ht1e/1f receptor agonist, on general behaviour and maximal electroshock seizure threshold in the rat. 1998. br.j.pharmacol. 123 237p.3. mckune cm, watts sw. characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. j pharmacol exp ther. 2001 apr;297(1):88-95.4. janssen p, tack j, sifrim d et al. influence of 5-ht1 receptor agonists on feline stomach relaxation. eur j pharmacol. 2004 may 25;492(2-3):259-67.
BRL 54443 Preparation Products And Raw materials
Raw materials
Preparation Products
BRL 54443 Suppliers
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View Lastest Price from BRL 54443 manufacturers
- Product
- Cobicistat 57477-39-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- BRL 54443 57477-39-1
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23