2,6-DIMETHYL-4-NITROPHENOL
- Product Name
- 2,6-DIMETHYL-4-NITROPHENOL
- CAS No.
- 2423-71-4
- Chemical Name
- 2,6-DIMETHYL-4-NITROPHENOL
- Synonyms
- NSC 2990;4-nitro-6-xylenol;4-NITRO-2,6-XYLENOL;2,6-Xylenol, 4-nitro-;2,6-DIMETHYL-4-NITROPHENOL;4-Nitro-2,6-dimethylphenol;Phenol, 2,6-dimethyl-4-nitro-;2,6-dimethyl-4-nitrophenolate;2,6-Dimethyl-4-nitrophenol>2,6-Dimethyl-4-nitrophenol 98%
- CBNumber
- CB2694098
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 2423-71-4.mol
2,6-DIMETHYL-4-NITROPHENOL Property
- Melting point:
- 168 °C (dec.)(lit.)
- Boiling point:
- 285.73°C (rough estimate)
- Density
- 1.1820 (estimate)
- refractive index
- 1.5774 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- pK1:7.190 (25°C)
- color
- Dark Yellow to Very Dark Yellow
- Water Solubility
- Insoluble in water.
- BRN
- 1873275
- CAS DataBase Reference
- 2423-71-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- ZE8225000
- Hazard Note
- Irritant
- HS Code
- 29089990
- Toxicity
- mouse,LDLo,intraperitoneal,500mg/kg (500mg/kg),"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 64, 1954.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 132713
- Product name
- 2,6-Dimethyl-4-nitrophenol
- Purity
- 98%
- Packaging
- 1g
- Price
- $41
- Updated
- 2023/06/20
- Product number
- 132713
- Product name
- 2,6-Dimethyl-4-nitrophenol
- Purity
- 98%
- Packaging
- 10g
- Price
- $111
- Updated
- 2023/06/20
- Product number
- D2531
- Product name
- 2,6-Dimethyl-4-nitrophenol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $80
- Updated
- 2025/07/31
- Product number
- D2531
- Product name
- 2,6-Dimethyl-4-nitrophenol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $319
- Updated
- 2025/07/31
- Product number
- D460155
- Product name
- 2,6-Dimethyl-4-nitrophenol
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
2,6-DIMETHYL-4-NITROPHENOL Chemical Properties,Usage,Production
Chemical Properties
orange crystalline powder
Uses
2,6-Dimethyl-4-nitrophenol is a useful compound for the production and characterization of bio-?oil from hardwood and softwood lignin.
Uses
2,6-Dimethyl-4-nitrophenol was used to study the disposition requirement for binding of p-nitrophenol and sodium p-nitrophenolate like substrates with cyclohexaamylaose. It was used as internal standard in determination of 4-nitrophenol and 3-methyl-4-nitrophenol in human urine by liquid chromatography combined with tandem mass spectrometry .
Synthesis Reference(s)
Synthetic Communications, 16, p. 63, 1986 DOI: 10.1080/00397918608057689
Synthesis
576-26-1
2423-71-4
4906-22-3
General method: A solid mixture of 2,6-dimethylphenol (1-3 eq.) and Bi(NO3)3-3H2O (1 eq.) or Fe(NO3)3-9H2O (1 eq.) was mixed with acetone (10 mL/mmol). The reaction mixture was stirred in air at room temperature or under reflux conditions for 2-24 hours (see Tables 1 and 2). Upon completion of the reaction, the insoluble material was removed by filtration through a diatomaceous earth pad and the residue was washed with acetone (~5 mL/mmol). The filtrate was treated with NaHCO3 (0.1 g/mmol) until CO2 release ceased. The insoluble material was removed by filtration again, followed by concentration under reduced pressure in a water bath at 25-35°C to remove the solvent. The nitration products were separated or purified by silica gel column chromatography to give pure phenolic compounds. All products were characterized by 1H NMR, 13C NMR and IR and identified by comparison with spectral data and melting points reported in the literature.
References
[1] Synthetic Communications, 2015, vol. 45, # 1, p. 143 - 150
2,6-DIMETHYL-4-NITROPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
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