ChemicalBook > CAS DataBase List > 2,6-DIMETHYL-4-NITROPHENOL

2,6-DIMETHYL-4-NITROPHENOL

Product Name: 2,6-DIMETHYL-4-NITROPHENOL
CAS No.: 2423-71-4
Chemical Name: 2,6-DIMETHYL-4-NITROPHENOL
Synonyms: NSC 2990;4-nitro-6-xylenol;4-NITRO-2,6-XYLENOL;2,6-Xylenol, 4-nitro-;2,6-DIMETHYL-4-NITROPHENOL;4-Nitro-2,6-dimethylphenol;Phenol, 2,6-dimethyl-4-nitro-;2,6-dimethyl-4-nitrophenolate;2,6-Dimethyl-4-nitrophenol>2,6-Dimethyl-4-nitrophenol 98%
CBNumber: CB2694098
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 2423-71-4.mol

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2,6-DIMETHYL-4-NITROPHENOL Property

Melting point:: 168 °C (dec.)(lit.)
Boiling point:: 285.73°C (rough estimate)
Density: 1.1820 (estimate)
refractive index: 1.5774 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: pK1:7.190 (25°C)
color: Dark Yellow to Very Dark Yellow
Water Solubility: Insoluble in water.
BRN: 1873275
CAS DataBase Reference: 2423-71-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: ZE8225000
Hazard Note: Irritant
HS Code: 29089990
Toxicity: mouse,LDLo,intraperitoneal,500mg/kg (500mg/kg),"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 64, 1954.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 132713
Product name: 2,6-Dimethyl-4-nitrophenol
Purity: 98%
Packaging: 1g
Price: $41
Updated: 2023/06/20

Sigma-Aldrich

Product number: 132713
Product name: 2,6-Dimethyl-4-nitrophenol
Purity: 98%
Packaging: 10g
Price: $111
Updated: 2023/06/20

TCI Chemical

Product number: D2531
Product name: 2,6-Dimethyl-4-nitrophenol
Purity: >98.0%(GC)
Packaging: 5g
Price: $80
Updated: 2025/07/31

TCI Chemical

Product number: D2531
Product name: 2,6-Dimethyl-4-nitrophenol
Purity: >98.0%(GC)
Packaging: 25g
Price: $319
Updated: 2025/07/31

TRC

Product number: D460155
Product name: 2,6-Dimethyl-4-nitrophenol
Packaging: 50mg
Price: $50
Updated: 2021/12/16

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2,6-DIMETHYL-4-NITROPHENOL Chemical Properties,Usage,Production

Chemical Properties

orange crystalline powder

Uses

2,6-Dimethyl-4-nitrophenol is a useful compound for the production and characterization of bio-?oil from hardwood and softwood lignin.

Uses

2,6-Dimethyl-4-nitrophenol was used to study the disposition requirement for binding of p-nitrophenol and sodium p-nitrophenolate like substrates with cyclohexaamylaose. It was used as internal standard in determination of 4-nitrophenol and 3-methyl-4-nitrophenol in human urine by liquid chromatography combined with tandem mass spectrometry .

Synthesis Reference(s)

Synthetic Communications, 16, p. 63, 1986 DOI: 10.1080/00397918608057689

Synthesis

576-26-1

2423-71-4

4906-22-3

General method: A solid mixture of 2,6-dimethylphenol (1-3 eq.) and Bi(NO3)3-3H2O (1 eq.) or Fe(NO3)3-9H2O (1 eq.) was mixed with acetone (10 mL/mmol). The reaction mixture was stirred in air at room temperature or under reflux conditions for 2-24 hours (see Tables 1 and 2). Upon completion of the reaction, the insoluble material was removed by filtration through a diatomaceous earth pad and the residue was washed with acetone (~5 mL/mmol). The filtrate was treated with NaHCO3 (0.1 g/mmol) until CO2 release ceased. The insoluble material was removed by filtration again, followed by concentration under reduced pressure in a water bath at 25-35°C to remove the solvent. The nitration products were separated or purified by silica gel column chromatography to give pure phenolic compounds. All products were characterized by 1H NMR, 13C NMR and IR and identified by comparison with spectral data and melting points reported in the literature.

References

[1] Synthetic Communications, 2015, vol. 45, # 1, p. 143 - 150

2,6-DIMETHYL-4-NITROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2423-71-4, 2,6-DIMETHYL-4-NITROPHENOLRelated Search:

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2,6-DIMETHYL-4-NITROPHENOL 98+%

2,6-Dimethyl-4-nitrophenol,4-Nitro-2,6-xylenol

2,6-DIMETHYL-4-NITROPHENOL FOR SYNTHESIS

4-Nitro-2,6-xylenol, 3,5-Dimethyl-4-hydroxynitrobenzene

2,6-Dimethyl-4-nitrophenol 98%

NSC 2990

2,6-Xylenol, 4-nitro-

4-Nitro-2,6-dimethylphenol

4-nitro-6-xylenol

2,6-DIMETHYL-4-NITROPHENOL

4-NITRO-2,6-XYLENOL

Phenol, 2,6-dimethyl-4-nitro-

2,6-dimethyl-4-nitrophenolate

2,6-Dimethyl-4-nitrophenol&gt

2,6-Dimethyl-4-nitrophenol in isopropanol

2423-71-4

O2NC6H2CH32OH

Oxygen Compounds

Phenols

Organic Building Blocks

Building Blocks