METHSUXIMIDE
- Product Name
- METHSUXIMIDE
- CAS No.
- 77-41-8
- Chemical Name
- METHSUXIMIDE
- Synonyms
- PM 396;Celontin;Petinutin;Mesuximide;Mesuximidum;Methsuximid;Metsuccimide;METHSUXIMIDE;RSYYMethsuximide;Methsuximide (500 mg)
- CBNumber
- CB2695398
- Molecular Formula
- C12H13NO2
- Formula Weight
- 203.24
- MOL File
- 77-41-8.mol
METHSUXIMIDE Property
- Melting point:
- 52-53°
- Boiling point:
- bp0.1 121-122°
- Density
- 1.1255 (rough estimate)
- refractive index
- 1.5440 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 2.8g/L(25 ºC)
Safety
- HS Code
- 2925190100
- Hazardous Substances Data
- 77-41-8(Hazardous Substances Data)
- Toxicity
- LD50 orally in mice: 0.9 g/kg (Marshall, Vallance)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1422001
- Product name
- Methsuximide
- Packaging
- 500mg
- Price
- $181.2
- Updated
- 2024/03/01
- Product number
- 19058
- Product name
- Methsuximide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $39
- Updated
- 2024/03/01
- Product number
- 19058
- Product name
- Methsuximide
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 19058
- Product name
- Methsuximide
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 19058
- Product name
- Methsuximide
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $249
- Updated
- 2024/03/01
METHSUXIMIDE Chemical Properties,Usage,Production
Description
Methsuximide is a succinimide that is converted to N-desmethylmethosuximide, a channel blocker that targets low threshold calcium currents. Methsuximide is a substrate of cytochrome P450 (CYP) isoform 2C19 that, in turn, inhibits CYP2C19-mediated metabolism of biguanides. Methsuximide has been shown to have anticonvulsant properties in clinical trials.
Chemical Properties
Light Yellow Oil
Originator
Celontin,Parke Davis,US,1957
Uses
A calcium channel succinimide antiepileptic drug. Anticonvulsant.
Definition
ChEBI: Methsuximide is an organic molecular entity.
Manufacturing Process
100 g of α-phenyl-α-methylsuccinic acid and 110 g of 40% aqueous methyl amine are heated together at 200 to 250°C until no more distillate is obtained. Upon vacuum distillation of the residue, the N-methyl-α-phenyl-αmethylsuccinimide, of BP 121° to 122°C at 0.1 mm is obtained. After recrystallization from aqueous ethanol, this compound melts at 52° to 53°C.
brand name
Celontin (Parke-Davis).
Therapeutic Function
Anticonvulsant
Clinical Use
Although methsuximide is less commonly used, it may be indicated for the control of absence seizures refractory to other drugs. Although it does not precipitate tonic-clonic convulsions, it often is combined with phenytoin or phenobarbital when absence seizures coexist with tonic-clonic symptoms. Much of the efficacy of methsuximide is attributed to its desmethyl metabolite. The half-life of methsuximide is between 2.6 and 4.0 hours, but the half-life for N-desmethylsuximide is 25 hours, causing it to accumulate substantially. Concentrations of greater than 40 g/mL may be associated with toxicity. Methsuximide is considered to be more toxic than ethosuximide.
References
[1] nicholls, p. j., and orton, t.c. the physiological disposition of 14c-methsuximide in the rat. br.j.pharmacol. 45(1), 48-59 (1972).
[2] chen g, weston j k, bratton a c. anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide[j]. epilepsia, 1963, 4(1‐4): 66-76.
[3] sigler m, strassburg h m, boenigk h e. effective and safe but forgotten: methsuximide in intractable epilepsies in childhood[j]. seizure, 2001, 10(2): 120-124.
[4] wright j d, helsby n a, ward s a. the role of s‐mephenytoin hydroxylase (cyp2c19) in the metabolism of the antimalarial biguanides[j]. british journal of clinical pharmacology, 1995, 39(4): 441-444.
[5] guengerich f p. human cytochrome p450 enzymes[m]//cytochrome p450. springer us, 1995: 473-535.
METHSUXIMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHSUXIMIDE manufacturers
- Product
- METHSUXIMIDE 77-41-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-22
- Product
- METHSUXIMIDE 77-41-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 10kg
- Release date
- 2018-12-18