4,4-dimethyl-2-pyrrolidinone

Product Name: 4,4-dimethyl-2-pyrrolidinone
CAS No.: 66899-02-3
Chemical Name: 4,4-dimethyl-2-pyrrolidinone
Synonyms: 4,4-dimethylpyrrolidin;2-PYRROLIDONE,4,4-DIMETHYL;4,4-Dimethyl-2-pyrrolidone;4,4-diMethylpyrrolidin-2-one;4,4-dimethyl-2-pyrrolidinone;2-pyrrolidinone, 4,4-dimethyl-;4,4-Dimethyl-2-pyrrolidinone,95%
CBNumber: CB51521886
Molecular Formula: C6H11NO
Formula Weight: 113.16
MOL File: 66899-02-3.mol

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4,4-dimethyl-2-pyrrolidinone Property

Melting point:: 38-40°
Boiling point:: 150-155℃ (18 Torr)
Density: 0.945±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 16.70±0.40(Predicted)
form: Solid
color: White to cream
Water Solubility: Sparingly soluble in water.(0.26 g/L) (25°C),
Sensitive: Air Sensitive

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Safety

HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: D495688
Product name: 4,4-Dimethyl-2-pyrrolidinone
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD74951
Product name: 4,4-Dimethyl-2-pyrrolidone
Packaging: 250mg
Price: $115
Updated: 2021/12/16

Matrix Scientific

Product number: 048080
Product name: 4,4-Dimethyl-2-pyrrolidinone
Purity: 97%
Packaging: 5g
Price: $122
Updated: 2021/12/16

Matrix Scientific

Product number: 048080
Product name: 4,4-Dimethyl-2-pyrrolidinone
Purity: 97%
Packaging: 500mg
Price: $26
Updated: 2021/12/16

Matrix Scientific

Product number: 048080
Product name: 4,4-Dimethyl-2-pyrrolidinone
Purity: 97%
Packaging: 1g
Price: $40
Updated: 2021/12/16

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4,4-dimethyl-2-pyrrolidinone Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Synthesis

130912-54-8

66899-02-3

The general procedure for the synthesis of 4,4-dimethyl-2-pyrrolidinone from ethyl 3,3-dimethyl-4-nitrobutanoate was as follows: ethyl 3,3-dimethyl-4-nitrobutanoate (22.65 g, 119.8 mmol) was dissolved in methanol (120 ml), followed by the addition of 10% palladium/activated carbon catalyst (250 mg). The reaction mixture was transferred to a hydrogenation unit (Parr Instrument Company), operated under evacuation and the reaction mixture was stirred at 110 °C. The reaction mixture was subjected to five hydrogenation operations with hydrogen (4.4 atmospheres) over a period of 16 hours. Upon completion of the reaction, the reaction mixture was filtered, the catalyst was washed with methanol, and the solvent was subsequently removed by evaporation to afford the oily product 4,4-dimethyl-2-pyrrolidinone (13.14 g, 97% yield).

References

[1] Patent: US2008/39456, 2008, A1. Location in patent: Page/Page column 44

4,4-dimethyl-2-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4-dimethyl-2-pyrrolidinone Suppliers

China 56 India 2 United Kingdom 4 United States 8 Global 70

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View Lastest Price from 4,4-dimethyl-2-pyrrolidinone manufacturers

Career Henan Chemical Co

Product: 4,4-dimethyl-2-pyrrolidinone 66899-02-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-25

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4,4-dimethyl-2-pyrrolidinone

4,4-diMethylpyrrolidin-2-one

4,4-Dimethyl-2-pyrrolidone

2-pyrrolidinone, 4,4-dimethyl-

2-PYRROLIDONE,4,4-DIMETHYL

4,4-dimethylpyrrolidin

4,4-Dimethyl-2-pyrrolidinone,95%

66899-02-3