ChemicalBook > CAS DataBase List > 4,4-dimethyl-2-pyrrolidinone

4,4-dimethyl-2-pyrrolidinone

Product Name
4,4-dimethyl-2-pyrrolidinone
CAS No.
66899-02-3
Chemical Name
4,4-dimethyl-2-pyrrolidinone
Synonyms
4,4-dimethylpyrrolidin;2-PYRROLIDONE,4,4-DIMETHYL;4,4-Dimethyl-2-pyrrolidone;4,4-diMethylpyrrolidin-2-one;4,4-dimethyl-2-pyrrolidinone;2-pyrrolidinone, 4,4-dimethyl-;4,4-Dimethyl-2-pyrrolidinone,95%
CBNumber
CB51521886
Molecular Formula
C6H11NO
Formula Weight
113.16
MOL File
66899-02-3.mol
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4,4-dimethyl-2-pyrrolidinone Property

Melting point:
38-40°
Boiling point:
150-155℃ (18 Torr)
Density 
0.945±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
16.70±0.40(Predicted)
form 
Solid
color 
White to cream
Water Solubility 
Sparingly soluble in water.(0.26 g/L) (25°C),
Sensitive 
Air Sensitive
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Safety

HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
D495688
Product name
4,4-Dimethyl-2-pyrrolidinone
Packaging
500mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD74951
Product name
4,4-Dimethyl-2-pyrrolidone
Packaging
250mg
Price
$115
Updated
2021/12/16
Matrix Scientific
Product number
048080
Product name
4,4-Dimethyl-2-pyrrolidinone
Purity
97%
Packaging
5g
Price
$122
Updated
2021/12/16
Matrix Scientific
Product number
048080
Product name
4,4-Dimethyl-2-pyrrolidinone
Purity
97%
Packaging
500mg
Price
$26
Updated
2021/12/16
Matrix Scientific
Product number
048080
Product name
4,4-Dimethyl-2-pyrrolidinone
Purity
97%
Packaging
1g
Price
$40
Updated
2021/12/16
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4,4-dimethyl-2-pyrrolidinone Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Synthesis

130912-54-8

66899-02-3

The general procedure for the synthesis of 4,4-dimethyl-2-pyrrolidinone from ethyl 3,3-dimethyl-4-nitrobutanoate was as follows: ethyl 3,3-dimethyl-4-nitrobutanoate (22.65 g, 119.8 mmol) was dissolved in methanol (120 ml), followed by the addition of 10% palladium/activated carbon catalyst (250 mg). The reaction mixture was transferred to a hydrogenation unit (Parr Instrument Company), operated under evacuation and the reaction mixture was stirred at 110 °C. The reaction mixture was subjected to five hydrogenation operations with hydrogen (4.4 atmospheres) over a period of 16 hours. Upon completion of the reaction, the reaction mixture was filtered, the catalyst was washed with methanol, and the solvent was subsequently removed by evaporation to afford the oily product 4,4-dimethyl-2-pyrrolidinone (13.14 g, 97% yield).

References

[1] Patent: US2008/39456, 2008, A1. Location in patent: Page/Page column 44

4,4-dimethyl-2-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4,4-dimethyl-2-pyrrolidinone manufacturers

Career Henan Chemical Co
Product
4,4-dimethyl-2-pyrrolidinone 66899-02-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-25

66899-02-3, 4,4-dimethyl-2-pyrrolidinoneRelated Search:

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  • 4,4-dimethyl-2-pyrrolidinone
  • 4,4-diMethylpyrrolidin-2-one
  • 4,4-Dimethyl-2-pyrrolidone
  • 2-pyrrolidinone, 4,4-dimethyl-
  • 2-PYRROLIDONE,4,4-DIMETHYL
  • 4,4-dimethylpyrrolidin
  • 4,4-Dimethyl-2-pyrrolidinone,95%
  • 66899-02-3