4,6-DIFLUORO-3-IODOINDAZOLE
- Product Name
- 4,6-DIFLUORO-3-IODOINDAZOLE
- CAS No.
- 887567-79-5
- Chemical Name
- 4,6-DIFLUORO-3-IODOINDAZOLE
- Synonyms
- 4,6-DIFLUORO-3-IODOINDAZOLE;3-Iodo-4,6-difluoro indazole;4,6-Difluoro-3-iodo-2H-indazole;4,6-Difluoro-3-iodo-1H-indazole;1H-Indazole, 4,6-difluoro-3-iodo-
- CBNumber
- CB2695828
- Molecular Formula
- C7H3F2IN2
- Formula Weight
- 280.01
- MOL File
- Mol file
4,6-DIFLUORO-3-IODOINDAZOLE Property
- Boiling point:
- 355.7±37.0 °C(Predicted)
- Density
- 2.229±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 10.47±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0047000
- Product name
- 4,6-DIFLUORO-3-IODOINDAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.23
- Updated
- 2021/12/16
- Product number
- 0826DC
- Product name
- 4,6-Difluoro-3-iodo-1H-indazole
- Packaging
- 1g
- Price
- $733
- Updated
- 2021/12/16
- Product number
- 887567795
- Product name
- 4,6-Difluoro-3-iodo-1H-indazole
- Packaging
- 1g
- Price
- $658.35
- Updated
- 2021/12/16
- Product number
- A285195
- Product name
- 4,6-Difluoro-3-iodo-1H-indazole
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- A285195
- Product name
- 4,6-Difluoro-3-iodo-1H-indazole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $113
- Updated
- 2021/12/16
4,6-DIFLUORO-3-IODOINDAZOLE Chemical Properties,Usage,Production
Synthesis
885520-26-3
887567-79-5
Example 10: Synthesis of 1.2-(4,6-difluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxyisopropylamide Step 1: Synthesis of 4,6-difluoro-3-iodo-1H-indazole At room temperature, 4,6-difluoro-1H-indazole (1.16 g, 7.53 mmol) was dissolved in DMF (60 mL) and potassium hydroxide (1.27 g, 22.6 mmol) and iodine (2.87 g, 11.3 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 2 h. The reaction solution was maroon in color. After completion of the reaction, the reaction was quenched with 10% Na2S2O3 aqueous solution and diluted with water. The mixture was extracted with EtOAc (2×). The organic phases were combined, washed sequentially with water, saturated LiCl solution and saturated NaCl solution, dried over MgSO4 and concentrated to give 4,6-difluoro-3-iodo-1H-indazole (2.18 g) as a light brown solid.
References
[1] Patent: WO2013/30138, 2013, A1. Location in patent: Page/Page column 262; 263
4,6-DIFLUORO-3-IODOINDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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