6-Fluoro-1H-indazol-3-ol
- Product Name
- 6-Fluoro-1H-indazol-3-ol
- CAS No.
- 862274-39-3
- Chemical Name
- 6-Fluoro-1H-indazol-3-ol
- Synonyms
- 6-Fluoro-1H-indazol-3-ol;6-Fluoro-1H-indazol-3(2H);6-Fluoro-1H-indazol-3(2H)-one;6-Fluoro-1,2-dihydro-indazol-3-one;6-Fluoro-1,2-dihydro-3H-indazol-3-one;3H-INDAZOL-3-ONE, 6-FLUORO-1,2-DIHYDRO
- CBNumber
- CB81117956
- Molecular Formula
- C7H5FN2O
- Formula Weight
- 152.13
- MOL File
- 862274-39-3.mol
6-Fluoro-1H-indazol-3-ol Property
- Boiling point:
- 185.9±19.0 °C(Predicted)
- Density
- 1.366±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 11.26±0.20(Predicted)
- Appearance
- Light yellow to light brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F600253
- Product name
- 6-Fluoro-1H-indazol-3-ol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F600253
- Product name
- 6-Fluoro-1H-indazol-3-ol
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- PC201329
- Product name
- 6-Fluoro-1H-indazol-3(2H)-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- PC201329
- Product name
- 6-Fluoro-1H-indazol-3(2H)-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $76
- Updated
- 2021/12/16
- Product number
- Z5210
- Product name
- 6-Fluoro-1H-indazol-3(2H)-one
- Packaging
- 1g
- Price
- $315
- Updated
- 2021/12/16
6-Fluoro-1H-indazol-3-ol Chemical Properties,Usage,Production
Synthesis
446-32-2
862274-39-3
General procedure for the synthesis of 6-fluoro-1H-indazol-3-ol from 2-amino-4-fluorobenzoic acid: 2-amino-4-fluorobenzoic acid (25 g, 161.2 mmol) was suspended in 250 ml of deionized water and 39 ml of concentrated hydrochloric acid. A 30 ml aqueous solution of sodium nitrite (11.2 g, 161.2 mmol) was slowly added dropwise under ice bath conditions, keeping the temperature below 10 °C. After the dropwise addition, the reaction was stirred at room temperature for 30 min. Subsequently, 250 ml of aqueous solution of sodium sulfite (69 g, 400 mmol) was added and the reaction was continued with stirring for 2 hours. After completion of the reaction, 30 ml of concentrated hydrochloric acid was added and the reaction mixture was left to stand overnight. On the following day, the reaction mixture was heated and refluxed for 9 h. At the end of the reaction, it was cooled to room temperature. The pH of the reaction solution was adjusted to 5.5 with sodium bicarbonate solution, the precipitate was collected by filtration and washed with deionized water and dried to obtain the target product 6-fluoro-1H-indazol-3-ol. Yield: 19.8 g, 81% yield, mass spectrometry detection [M+H]+: 152.94.
References
[1] Patent: WO2005/73199, 2005, A1. Location in patent: Page/Page column 33-34
[2] Patent: US2005/197348, 2005, A1. Location in patent: Page/Page column 11
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1579 - 1587
6-Fluoro-1H-indazol-3-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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