ChemicalBook > CAS DataBase List > CYPROHEPTADINE HYDROCHLORIDE

CYPROHEPTADINE HYDROCHLORIDE

Product Name
CYPROHEPTADINE HYDROCHLORIDE
CAS No.
969-33-5
Chemical Name
CYPROHEPTADINE HYDROCHLORIDE
Synonyms
CYPROHEPTADINE HCL;4-(5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDINE)-METHYLPIPERIDINE HYDROCHLORIDE;nuran;peritol;ANAREXOL;periactinsyrup;Cycloheptadine HCl;CYPROHEPTADINE HCL BP;periactinhydrochloride;periactinolhydrochloride
CBNumber
CB2698687
Molecular Formula
C21H21N.ClH
Formula Weight
323.86
MOL File
969-33-5.mol
More
Less

CYPROHEPTADINE HYDROCHLORIDE Property

Melting point:
254-256.5 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
storage temp. 
Inert atmosphere,Room Temperature
solubility 
ethanol: soluble
form 
solid
color 
Crystals from EtOH/Et2O
Water Solubility 
Soluble in water (15mM)
Stability:
Hygroscopic
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
TM7050000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 orl-rat: 295 mg/kg DRUGAY 6,340,82
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

AK Scientific
Product number
J53419
Product name
CyproheptadineHCl
Packaging
5g
Price
$47.2
Updated
2021/12/16
ApexBio Technology
Product number
B3309
Product name
Cyproheptadine hydrochloride
Packaging
10mM(in 1mL DMSO)
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC61445
Product name
Cyproheptadine hydrochloride
Packaging
100mg
Price
$50
Updated
2021/12/16
ApexBio Technology
Product number
B3309
Product name
Cyproheptadine hydrochloride
Packaging
1unit
Price
$28
Updated
2021/12/16
AK Scientific
Product number
M230
Product name
CyproheptadineHCl
Packaging
1g
Price
$29
Updated
2021/12/16
More
Less

CYPROHEPTADINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Periactin,Merck Sharp and Dohme,US,1961

Uses

Antipruritic;5-HT antagonist

Uses

Cyproheptadine hydrochloride is an antihistamine in which antiserotonin activity has been demonstrated both in vivo and in vitro. As yet, however, there is no evidence that this action contributes to clinical therapeutic effects. Anticholinergic and sedative effects are observed. Cyproheptadine may be more effective than other H1 blockers in the management of cold urticaria.

Definition

ChEBI: The hydrochloride salt of cyproheptadine. Note that the drug named cyproheptadine hydrochloride generally refers to cyproheptadine hydrochloride sesquihydrate.

Manufacturing Process

(A) Preparation of 1-Methyl-4-Piperidyl-Magnesium Chloride: Magnesium turnings (5.45 g, 0.22 g-atom) were placed in a 500 ml 3-necked flask provided with a condenser, Hershberg stirrer and dropping funnel and protected with a drying tube. An atmosphere of dry nitrogen was maintained in the apparatus throughout the reaction. The magnesium was covered with 20 ml of dry tetrahydrofuran. A crystal of iodine and 1.2 g of ethyl bromide were added and after the reaction had subsided (formation of ethylmagnesium bromide) a solution of 29.4 g (0.22 mol) of 4-chloro-1-methyl-piperidine in dry tetrahydrofuran (total volume, 103 ml) was added dropwise at such a rate that gentle reflux was maintained.
The solution of 4-chloro-1-methylpiperidine in tetrahydrofuran was dried over calcium hydride at ice-bath temperature prior to use. When the addition of the halide was complete the reaction mixture was refluxed with stirring for one hour. In some subsequent experiments this period of refluxing was omitted with no deleterious result.
The solution of 4-chloro-1-methylpiperidine in tetrahydrofuran was dried over calcium hydride at ice-bath temperature prior to use. When the addition of the halide was complete the reaction mixture was refluxed with stirring for one hour. In some subsequent experiments this period of refluxing was omitted with no deleterious result.
The solvent was evaporated from the combined benzene extracts to give 33.4 g of a clear light brown resin. Crystallization from an alcohol-water mixture gave 19.5 g of 1-methyl-4-(5-hydroxy-5-dibenzo[a,e]cycloheptatrienyl)- piperidine, MP 156° to 157°C. Two recrystallizations from alcohol-water mixtures followed by two recrystallizations from benzene-hexane mixtures gave analytically pure product, MP 166.7° to 167.7°C.
(C) Preparation of 1-Methyl-4-(5-Dibenzo[a,e]Cycloheptatrienylidene)- Piperidine Hydrochloride: 1-Methyl-4-(5-hydroxy-5-dibenzo[a,e] cycloheptatrienyl)-piperidine (3.05 g, 0.01 mol) was dissolved in glacial acetic acid, 15 ml. The solution was saturated with dry hydrogen chloride with external cooling. A white solid separated. Acetic anhydride (3.07 g, 0.03 mol) was added and the mixture heated on the steam bath for one hour. The solid dissolved in the first 5 minutes of the heating period.
The reaction mixture was poured into 25 ml of water and the mixture made strongly basic with 10N sodium hydroxide solution. The mixture was extracted 3 times with 50 ml portions of benzene, the combined extracts washed with water and concentrated to a volume of approximately 50 ml. The solution was saturated with dry hydrogen chloride and the white crystalline product collected and dried. The yield of product, MP 251.6° to 252.6°C (dec.) was 2.5 g. Recrystallization from a mixture of absolute alcohol and absolute ether gave a product, MP 252.6° to 253.6°C. A sample was analyzed after drying for 7 hours at 110°C over phosphorus pentoxide in vacuo.
(D) Preparation of 1-Methyl-4-(5-Dibenzo[a,e]Cycloheptatrienylidene)- Piperidine: The hydrochloride salt, 4.3 g, was suspended in 100 ml of warm water and the mixture made strongly alkaline by the addition of 15 ml of 5% sodium hydroxide. The mixture was extracted with four 50 ml portions of benzene and the extracts dried over sodium sulfate. Evaporation of the benzene on the steam-bath at reduced pressure left 3.7 g (97%) of the base,MP 110.3° to 111.3°C. Recrystallization from a mixture of alcohol and water gave product, MP 112.3° to 113.3°C.

brand name

Periactin (Merck).

Therapeutic Function

Antipruritic, Antihistaminic, Appetite stimulant

General Description

Cyproheptadinehydrochloride, 4-(5H-dibenzo-[a,d]-cyclohepten-5-ylidine)-1-methylpiperidine hydrochloride sesquihydrate(Periactin), is slightly soluble in water and sparingly solublein alcohol.
Cyproheptadine possesses both antihistamine and antiserotoninactivity and is used as an antipruritic agent. It isindicated for the treatment of hypersensitivity reactions,perennial, and seasonal allergic rhinitis; vasomotor rhinitis;allergic conjunctivitis, uncomplicated allergic skin manifestationsof urticaria and angioedema; amelioration of allergicreactions to blood or plasma; and cold urticaria. It is alsoused off-label for nightmares associated with posttraumaticstress disorder (PTSD), prevention of migraine, suppressionof vascular headaches, and appetite stimulation. Sedation isthe most prominent side effect, and this is usually brief, disappearingafter 3 or 4 days of treatment.

Biological Activity

Non-selective 5HT 2 antagonist, migraine prophylactic.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: jaundice, liver function tests impaired, gastrointestinal effects. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. Whenheated

Drug interactions

Potentially hazardous interactions with other drugs
Analgesics: sedative properties increased with opioid analgesics.

Metabolism

Undergoes almost complete metabolism in the liver. The main metabolite found in humans is a quaternary ammonium glucuronide conjugate of cyproheptadine. 40% is excreted in the urine mainly as metabolites and 2-20% via the faeces.

storage

Room temperature

References

[1] levine b, green-johnson d, hogan s, smialek je. a cyproheptadine fatality. j anal toxicol. 1998 jan-feb;22(1):72-4.
[2] lin oa, karim za, vemana hp, espinosa ev, khasawneh ft. the antidepressant 5-ht2a receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. plos one. 2014 jan 23;9(1):e87026.

CYPROHEPTADINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CYPROHEPTADINE HYDROCHLORIDE Suppliers

xi'an renyang Biotechnology Co., Ltd.
Tel
13299086402
Email
renyangbiotech@163.com
Country
China
ProdList
80
Advantage
58
Shanghai Gukang Biotechnology Co., LTD
Tel
13564510648
Fax
021-54301252
Email
info@kanghaopharm.com
Country
China
ProdList
113
Advantage
58
Shandong Debek Bioengineering Co. LTD
Tel
13854830608; 13854830608
Email
13854830608@163.com
Country
China
ProdList
1507
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2045
Advantage
56
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Watson Biotechnology Co.,Ltd
Tel
027-59207879 1972026995 18140587686
Fax
QQ:1972026995
Email
sales@3600chem.com
Country
China
ProdList
4661
Advantage
55
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
Hubei Kangbaotai Finechem Co., Ltd.
Tel
+86 (27) 8778653
Fax
+86 (27) 8773-8652
Email
13720228325@163.com
Country
China
ProdList
337
Advantage
58
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Boen pharm
Tel
86 512-62572107 62962707
Fax
86 512-62922078
Country
China
ProdList
800
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Hubei widely chemical technology Co., Ltd.
Tel
027-83991130 18627774460
Fax
027-83991130
Email
1718093273@QQ.COM
Country
China
ProdList
1879
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Wuhan Magic Biological Technology Co., Ltd.
Tel
18872289958、027-52304252、3400508168
Fax
027-52304252
Email
3400508168@qq.com
Country
China
ProdList
1910
Advantage
55
Wuhan HongxinKang Fine Chemical Co., Ltd.
Tel
027-59362599 18674037007
Fax
027-84802889
Email
zhuoxingwc@163.com
Country
China
ProdList
949
Advantage
58
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
1996
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Conier Chem & Pharma Limited
Tel
13368167990
Email
sales@conier.com
Country
China
ProdList
2833
Advantage
58
Shanghai Bojing Chemical Co., Ltd
Tel
021-37199966 13681836088
Fax
021-37597788
Email
bj@bj-chem.com
Country
China
ProdList
463
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4397
Advantage
58
Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.
Tel
029-88380327 17691182729
Fax
029-88380327
Email
1018@dideu.com
Country
China
ProdList
1993
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Guangzhou Belka Biological Technology Co., Ltd.
Tel
+86-18665676617
Fax
18665676617
Country
China
ProdList
957
Advantage
58
Hubei Xingyinhe Chemical Co., Ltd.
Tel
15308653513
Fax
027-63606400
Email
hubeixyh@qq.com
Country
China
ProdList
700
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Wuhan Xiang Dingda Biotechnology Co., Ltd.
Tel
13476180745
Email
1875023037@qq.com
Country
CHINA
ProdList
435
Advantage
58
Hong Kong Excellence Biotechnology Co., Ltd.
Tel
Fax
wickrme:chemical888
Email
ada@sh-teruiop.com
Country
China
ProdList
875
Advantage
58
Hebei Yanxi Chemical Co., Ltd.
Tel
+8617531190177
Email
peter@yan-xi.com
Country
China
ProdList
5857
Advantage
58
Hebei Mojin Biotechnology Co., Ltd
Tel
+86 13288715578 +8613288715578
Email
sales@hbmojin.com
Country
China
ProdList
12834
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Xi'an MC Biotech, Co., Ltd.
Tel
029-89275612 +8618991951683
Fax
8618991951683
Email
mcbio_sales@163.com
Country
China
ProdList
2251
Advantage
58
Shanghai Biolang Biotechnology Co., Ltd.
Tel
+86-15970428662 +86-13397199602
Fax
+8613397199602
Email
Niky@biolang.cn
Country
China
ProdList
515
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Wuhan Demeikai Biotechnology Co., Ltd
Tel
+8618942921723
Email
info@dmksw.xin
Country
China
ProdList
717
Advantage
58
Guangzhou TongYi biochemistry technology Co.,LTD
Tel
+8613073028829
Email
mack@tongyon.com
Country
China
ProdList
2994
Advantage
58
Wuhan Fortuna Chemical Co., Ltd
Tel
+86-027-59207850
Fax
86-27-59524646
Email
info@fortunachem.com
Country
China
ProdList
5975
Advantage
58
Hebei Chuanghai Biotechnology Co,.LTD
Tel
+86-13131129325
Fax
86-0311-66562153
Email
sales1@chuanghaibio.com
Country
China
ProdList
5889
Advantage
58
More
Less

View Lastest Price from CYPROHEPTADINE HYDROCHLORIDE manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Cycloheptadine HCl 969-33-5
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cyproheptadine hydrochloride 969-33-5
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%-100.5%; USP
Supply Ability
500kg
Release date
2021-09-11
Hebei Weibang Biotechnology Co., Ltd
Product
CYPROHEPTADINE HYDROCHLORIDE 969-33-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28

969-33-5, CYPROHEPTADINE HYDROCHLORIDERelated Search:


  • CYPROHEPTADINE HYDROCHLORIDE(GRP B SL NO.1124)
  • Cycloheptadine Hydrochloride
  • 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidinehydrochloride
  • 4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidinehydrochloride
  • 4-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-piperidinhydrochloride
  • cyproheptadienehydrochloride
  • nuran
  • 4-(5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDINE)-METHYLPIPERIDINE HYDROCHLORIDE
  • CYPROHEPTADINE HCL
  • CyproheptadineHclCyproheptadineHclBp
  • CYPROHEPTADINEHYDROCHLORIDE(ANHYDROUS)
  • ANAREXOL
  • CYPROHEPTADINE HCL BP
  • Cyproheptadine hydrochloride (Periactin)
  • Cyproheptadine hydrochloride
  • periactinhydrochloride
  • periactinolhydrochloride
  • periactinsyrup
  • peritol
  • Cyproheptadine hydrochloride,CYPROHEPTADINE HCL, periactinolhydrochloride
  • 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride
  • Cyproheptadine hydrochloride USP/EP/BP
  • Cyproheptadine hydrochloride USP/EP/BP USP/EP/BP
  • 1-Methyl-4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine hydrochloride
  • Cyproheptadinhydrochlorid
  • Cyheptadine hydrochloride
  • Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride (1:1)
  • Cycloheptadine HCl
  • 969-33-5
  • 354-29-4
  • C21H21NHCl1H2O
  • C21H21NClH
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidines
  • Serotonin receptor
  • Active Pharmaceutical Ingredients