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L-858051

Product Name
L-858051
CAS No.
115116-37-5
Chemical Name
L-858051
Synonyms
L-858051;L-858,051 (hydrochloride);L858,051 (hydrochloride),L 858,051 (hydrochloride);7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL;FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE;8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL
CBNumber
CB2703053
Molecular Formula
C29H50Cl2N2O7
Formula Weight
609.62
MOL File
Mol file
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L-858051 Property

storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21206
Product name
L-858,051 (hydrochloride)
Purity
≥95%
Packaging
500μg
Price
$36
Updated
2023/06/20
Cayman Chemical
Product number
21206
Product name
L-858,051 (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$66
Updated
2023/06/20
Cayman Chemical
Product number
21206
Product name
L-858,051 (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$277
Updated
2023/06/20
AK Scientific
Product number
1919CV
Product name
[(3R,4Ar,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]4-(4-methylpiperazin-1-yl)butanoate;dihydrochloride
Packaging
1mg
Price
$174
Updated
2021/12/16
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L-858051 Chemical Properties,Usage,Production

Description

L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase.1 L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes.2 L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.3,4,5

References

1. Laurenza, A., Khandelwal, Y., De Souza, N.J., et al. Stimulation of adenylate cyclase by water-soluble analogues of forskolin Mol. Pharmacol. 32(1),133-139(1987).
2. Joost, H.G., Habberfield, A.D., Simpson, I.A., et al. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action Mol. Pharmacol. 33(4),449-453(1988).
3. Funaki, C., Hodges, R.R., and Dartt, D.A. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland Am. J. Physiol. Cell Physiol. 293(5),C1551-C1560(2007).
4. Luo, S.-F., Chiu, C.-T., Tsao, H.-L., et al. Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells Cell. Signal. 9(2),159-167(1997).
5. Haj Slimane, Z., Bedioune, I., Lechêne, P., et al. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes Cardiovasc. Res. 102(1),97-106(2014).

L-858051 Preparation Products And Raw materials

Raw materials

Preparation Products

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L-858051 Suppliers

China 13 Japan 1 United Kingdom 1 United States 4 Global 19
VWR International
Tel
--
Fax
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Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82

115116-37-5, L-858051Related Search:

Forskolin

  • 8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL
  • 7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL
  • L-858051
  • FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE
  • L-858,051 (hydrochloride)
  • L858,051 (hydrochloride),L 858,051 (hydrochloride)
  • 115116-37-5