ChemicalBook > CAS DataBase List > (2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE
(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE
- Product Name
- (2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE
- CAS No.
- 205242-62-2
- Chemical Name
- (2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE
- Synonyms
- NAS-181;NAS-181 methanesulfonate;(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE
- CBNumber
- CB2707905
- Molecular Formula
- C20H30N2O7S
- Formula Weight
- 442.53
- MOL File
- 205242-62-2.mol
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(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE Property
- storage temp.
- Desiccate at -20°C
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N-Bromosuccinimide Price
Tocris
- Product number
- 1413
- Product name
- NAS-181
- Purity
- ≥97%(HPLC)
- Packaging
- 10
- Price
- $259
- Updated
- 2021/12/16
Tocris
- Product number
- 1413
- Product name
- NAS-181
- Purity
- ≥97%(HPLC)
- Packaging
- 50
- Price
- $1092
- Updated
- 2021/12/16
Usbiological
- Product number
- 460596
- Product name
- NAS-181
- Packaging
- 1mg
- Price
- $425
- Updated
- 2021/12/16
Usbiological
- Product number
- 255946
- Product name
- NAS-181
- Packaging
- 10mg
- Price
- $516
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0009847
- Product name
- NAS-181
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.99
- Updated
- 2021/12/16
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(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE Chemical Properties,Usage,Production
Uses
NAS-181 is a SR-1B antagonist.
Biological Activity
Potent, selective antagonist at the rat 5-HT 1B receptor (K i = 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance in vivo .
in vivo
NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions[1].
| Animal Model: | Rats[1] |
| Dosage: | 20 mg/kg |
| Administration: | S.c. |
| Result: | Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal?cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40?60%). |
(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE Preparation Products And Raw materials
Raw materials
Preparation Products
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(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE Suppliers
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205242-62-2, (2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATERelated Search:
(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE
2-PHENOXYMETHYL-MORPHOLINE
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