viloxazine
- Product Name
- viloxazine
- CAS No.
- 46817-91-8
- Chemical Name
- viloxazine
- Synonyms
- viloxazine;2-[(2-Ethoxyphenoxy)methyl]morpholine;Morpholine, 2-[(2-ethoxyphenoxy)methyl]-;Metrifonate Impurity 2-d6(Metrifonate EP Impurity B-d6)(Dichlorvos-d6)
- CBNumber
- CB0911793
- Molecular Formula
- C13H19NO3
- Formula Weight
- 237.29
- MOL File
- 46817-91-8.mol
viloxazine Property
- Melting point:
- 176-179 °C
- Boiling point:
- 379.83°C (rough estimate)
- Density
- 1.0942 (rough estimate)
- refractive index
- 1.5000 (estimate)
- pka
- pKa 8.1 (Uncertain)
- form
- Oil
- color
- Colorless to light yellow
- InChI
- InChI=1S/C13H19NO3/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11/h3-6,11,14H,2,7-10H2,1H3
- InChIKey
- YWPHCCPCQOJSGZ-UHFFFAOYSA-N
- SMILES
- N1CCOC(COC2=CC=CC=C2OCC)C1
N-Bromosuccinimide Price
- Product number
- AS233199
- Product name
- 2-((2-Ethoxyphenoxy)methyl)morpholine
- Purity
- 99%
- Packaging
- 1g
- Price
- $937
- Updated
- 2021/12/16
viloxazine Chemical Properties,Usage,Production
Originator
Vivalan,I.C.I. ,UK,1974
Uses
Viloxazine is approved by the FDA for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in paediatric patients (6-17 years old).
Definition
ChEBI: 2-[(2-ethoxyphenoxy)methyl]morpholine is an aromatic ether.
Manufacturing Process
2-Ethoxyphenol is first reacted with epichlorohydrin to give 1,2-epoxy-3-(o-
ethoxyphenoxy)-propane.
A mixture of crude (83%) 1,2-epoxy-3-(o-ethoxyphenoxy)propane (19.4
grams), 70.5 grams 2-aminoethyl hydrogen sulfate, 40.0 grams sodium
hydroxide, 400 ml ethanol and 200 ml water is stirred at 60°C for 18 hours
and is then evaporated to dryness. The residue is dissolved in 200 ml water
and the mixture is extracted three times with 150 ml of diethyl ether each
time. The combined extracts are dried over magnesium sulfate and
evaporated to dryness, The crude product (21.5 grams) is dissolved in
isopropanol (20 ml), 10.5 ml concentrated aqueous hydrochloric acid and 75
ml ethyl acetate are added and the mixture is cooled. The mixture is filtered
and there is thus obtained as solid product 2-(o-ethoxyphenoxymethyl)
morpholine hydrochloride, MP 179° to 182°C (8.6 grams; 38% yield based on
total epoxide used), according to US Patent 3,712,890.
Therapeutic Function
Psychotropic
Mechanism of action
Viloxazine works by inhibiting the reuptake of norepinephrine and possibly through interaction with 5- hydroxytryptamine receptors.
Synthesis
Viloxazine was synthesized via a four-step process. In the first step, 2-ethoxyphenol (9.1) was reacted with epichlorohydrin (9.2) in the presence of potassium carbonate and a phase transfer catalyst (n-Bu4NHSO4) to produce the epoxide (9.3) in almost equivalent yield. Next, the epoxide (9.3) was reacted with 2-aminoethylsulfuric acid (9.4) in the presence of a strong base to trigger the opening of the epoxide ring and subsequent cyclization to form 2-morpholine (9.5) in 40% yield. Finally, the free basic amine (9.5) was treated with concentrated hydrochloric acid, and the prepared salt was recrystallized from a water/isopropanol/ethyl acetate mixed solvent to obtain Viloxazine hydrochloride (9) with a purity of 99%.
viloxazine Preparation Products And Raw materials
Raw materials
Preparation Products
viloxazine Suppliers
- Tel
- 029-029-81120477 17792793610
- 1033@dideu.com
- Country
- China
- ProdList
- 9909
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6874
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +86-27-8746-5837 +8619945049750
- Fax
- 86 27 87772287
- info@finetechnology-ind.com
- Country
- China
- ProdList
- 9629
- Advantage
- 58
- Tel
- +86-0086-577-64498589 +86-15355981851
- Fax
- 0086-577-56994596
- sales@win-winchemical.com
- Country
- China
- ProdList
- 14359
- Advantage
- 58
View Lastest Price from viloxazine manufacturers
- Product
- viloxazine 46817-91-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-08
- Product
- Viloxazine
- Price
- US $25.00-500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 500ton/Month
- Release date
- 2021-09-10