2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
- Product Name
- 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
- CAS No.
- 35604-67-2
- Chemical Name
- 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
- Synonyms
- Viloxazine HCl;Viloxazine hydrochloride;Vivalan;Vicilan;Vivilan;Vivarint;Catatrol;ICI-58834;Viloxazin Hydrochloride;Adrenaline Impurity 43-13C6
- CBNumber
- CB2933621
- Molecular Formula
- C13H20ClNO3
- Formula Weight
- 273.7558
- MOL File
- 35604-67-2.mol
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Property
- Melting point:
- 178-180°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H
- InChIKey
- HJOCKFVCMLCPTP-UHFFFAOYSA-N
- SMILES
- C1(C=CC=CC=1OCC)OCC1OCCNC1.Cl
Safety
- HazardClass
- IRRITANT
- Toxicity
- LD50 in mice (mg/kg): 1000 orally, 60 i.v. (Brosnan)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML3133
- Product name
- Viloxazine hydrochloride
- Purity
- ≥95% (HPLC)
- Packaging
- 10 mg
- Price
- $73.2
- Updated
- 2025/07/31
- Product number
- SML3133
- Product name
- Viloxazine hydrochloride
- Purity
- ≥95% (HPLC)
- Packaging
- 50 mg
- Price
- $295
- Updated
- 2025/07/31
- Product number
- V312440
- Product name
- racViloxazineHydrochloride
- Packaging
- 1mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- V312440
- Product name
- racViloxazineHydrochloride
- Packaging
- 10mg
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- 058070
- Product name
- 2-((2-Ethoxyphenoxy)methyl)morpholinehydrochloride
- Purity
- 95%
- Packaging
- 500mg
- Price
- $229
- Updated
- 2021/12/16
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Originator
Vivalan,I.C.I. ,UK,1974
Uses
Rac Viloxazine Hydrochloride is research useful chemical used as an antidepressant.
Manufacturing Process
2-Ethoxyphenol is first reacted with epichlorohydrin to give 1,2-epoxy-3-(o-
ethoxyphenoxy)-propane.
A mixture of crude (83%) 1,2-epoxy-3-(o-ethoxyphenoxy)propane (19.4
grams), 70.5 grams 2-aminoethyl hydrogen sulfate, 40.0 grams sodium
hydroxide, 400 ml ethanol and 200 ml water is stirred at 60°C for 18 hours
and is then evaporated to dryness. The residue is dissolved in 200 ml water
and the mixture is extracted three times with 150 ml of diethyl ether each
time. The combined extracts are dried over magnesium sulfate and
evaporated to dryness, The crude product (21.5 grams) is dissolved in
isopropanol (20 ml), 10.5 ml concentrated aqueous hydrochloric acid and 75
ml ethyl acetate are added and the mixture is cooled. The mixture is filtered
and there is thus obtained as solid product 2-(o-ethoxyphenoxymethyl)
morpholine hydrochloride, MP 179° to 182°C (8.6 grams; 38% yield based on
total epoxide used), according to US Patent 3,712,890.
Therapeutic Function
Psychotropic
Biological Activity
Viloxazine (ICI 58,834) is an orally active serotonin norepinephrine modulating agent (SNMA) originally reported as a norepinephrine reuptake inhibitor (NRI) with antidepressant (ED10 from 0.3-1 mg/kg p.o. against reserpine-induced hypothermia in mice), while exhibiting less sedative efficacy (locomotor activity reduction ED10 from 3-10 mg/kg p.o. in mice) and no monoamine oxidase inhibitory potency. Viloxazine shows 5-HT2B antagonist and 5-HT2C agonist activity in vitro and increases extracellular 5-HT levels in the prefrontal cortex (PFC) in vivo, a brain area implicated in Attention deficit hyperactivity disorder (ADHD).
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 21-57721279
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 998
- Advantage
- 56
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
- Country
- China
- ProdList
- 1077
- Advantage
- 64
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 12952
- Advantage
- 65
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6874
- Advantage
- 55
- Tel
- 021-58088081 Q2635253576
- Fax
- QQ3382968513
- hailey@shsendpharm.com
- Country
- China
- ProdList
- 2081
- Advantage
- 55
View Lastest Price from 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride manufacturers
- Product
- Viloxazine hydrochloride，PhEur/USP(DMF) 35604-67-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2025-08-05
- Product
- Morpholine 35604-67-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-11
- Product
- 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride 35604-67-2
- Price
- US $8.00-0.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08