ChemicalBook > CAS DataBase List > 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

Product Name: 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
CAS No.: 35604-67-2
Chemical Name: 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
Synonyms: Viloxazine HCl;Viloxazine hydrochloride;Vivalan;Vicilan;Vivilan;Vivarint;Catatrol;ICI-58834;Viloxazin Hydrochloride;Adrenaline Impurity 43-13C6
CBNumber: CB2933621
Molecular Formula: C13H20ClNO3
Formula Weight: 273.7558
MOL File: 35604-67-2.mol

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2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Property

Melting point:: 178-180°C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H
InChIKey: HJOCKFVCMLCPTP-UHFFFAOYSA-N
SMILES: C1(C=CC=CC=1OCC)OCC1OCCNC1.Cl

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Safety

HazardClass: IRRITANT
Toxicity: LD50 in mice (mg/kg): 1000 orally, 60 i.v. (Brosnan)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3133
Product name: Viloxazine hydrochloride
Purity: ≥95% (HPLC)
Packaging: 10 mg
Price: $73.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3133
Product name: Viloxazine hydrochloride
Purity: ≥95% (HPLC)
Packaging: 50 mg
Price: $295
Updated: 2025/07/31

TRC

Product number: V312440
Product name: racViloxazineHydrochloride
Packaging: 1mg
Price: $155
Updated: 2021/12/16

TRC

Product number: V312440
Product name: racViloxazineHydrochloride
Packaging: 10mg
Price: $1230
Updated: 2021/12/16

Matrix Scientific

Product number: 058070
Product name: 2-((2-Ethoxyphenoxy)methyl)morpholinehydrochloride
Purity: 95%
Packaging: 500mg
Price: $229
Updated: 2021/12/16

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2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Vivalan,I.C.I. ,UK,1974

Uses

Rac Viloxazine Hydrochloride is research useful chemical used as an antidepressant.

Manufacturing Process

2-Ethoxyphenol is first reacted with epichlorohydrin to give 1,2-epoxy-3-(o- ethoxyphenoxy)-propane.
A mixture of crude (83%) 1,2-epoxy-3-(o-ethoxyphenoxy)propane (19.4 grams), 70.5 grams 2-aminoethyl hydrogen sulfate, 40.0 grams sodium hydroxide, 400 ml ethanol and 200 ml water is stirred at 60°C for 18 hours and is then evaporated to dryness. The residue is dissolved in 200 ml water and the mixture is extracted three times with 150 ml of diethyl ether each time. The combined extracts are dried over magnesium sulfate and evaporated to dryness, The crude product (21.5 grams) is dissolved in isopropanol (20 ml), 10.5 ml concentrated aqueous hydrochloric acid and 75 ml ethyl acetate are added and the mixture is cooled. The mixture is filtered and there is thus obtained as solid product 2-(o-ethoxyphenoxymethyl) morpholine hydrochloride, MP 179° to 182°C (8.6 grams; 38% yield based on total epoxide used), according to US Patent 3,712,890.

Therapeutic Function

Psychotropic

Biological Activity

Viloxazine (ICI 58,834) is an orally active serotonin norepinephrine modulating agent (SNMA) originally reported as a norepinephrine reuptake inhibitor (NRI) with antidepressant (ED10 from 0.3-1 mg/kg p.o. against reserpine-induced hypothermia in mice), while exhibiting less sedative efficacy (locomotor activity reduction ED10 from 3-10 mg/kg p.o. in mice) and no monoamine oxidase inhibitory potency. Viloxazine shows 5-HT2B antagonist and 5-HT2C agonist activity in vitro and increases extracellular 5-HT levels in the prefrontal cortex (PFC) in vivo, a brain area implicated in Attention deficit hyperactivity disorder (ADHD).

2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride manufacturers

Guangzhou Weiaokang Pharmaceutical Technology Co., Ltd

Product: Viloxazine hydrochloride，PhEur/USP(DMF) 35604-67-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2025-08-05

Chongqing Soarwin Technology Co., Ltd

Product: Morpholine 35604-67-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2025-04-11

Henan Fengda Chemical Co., Ltd

Product: 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride 35604-67-2
Price: US $8.00-0.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

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Morpholine, 2-(2-ethoxyphenoxy)methyl-, hydrochloride

ICI-58834

Vivalan

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rac Viloxazine Hydrochloride

2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

(+/-)-2-(o-EthoxyphenoxyMethyl)Morpholine

Catatrol

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Viloxazin Hydrochloride

Vivarint

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2-[(2-Ethoxy phenoxy)methyl]morpholine HCl

Adrenaline Impurity 43-13C6

Viloxazine hydrochloride - Bio-X ?

Viloxazine hydrochloride，PhEur/USP(DMF)

35604-67-2

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