5-Nitrofurfural Property

Melting point:

37-39 °C(lit.)

Boiling point:

121 °C10 mm Hg(lit.)

Density 

1.349 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.59(lit.)

Flash point:

92 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)

form 

Crystalline Low Melting Solid

color 

Yellow to brown

Water Solubility 

sparingly soluble

Sensitive 

Air & Light Sensitive

BRN 

120539

InChIKey

SXINBFXPADXIEY-UHFFFAOYSA-N

CAS DataBase Reference

698-63-5(CAS DataBase Reference)

NIST Chemistry Reference

2-Furancarboxaldehyde, 5-nitro-(698-63-5)

Safety

Hazard Codes 

F,Xi,Xn

Risk Statements 

11-68-10

Safety Statements 

16-36/37

RIDADR 

UN 1325 4.1/PG 2

WGK Germany 

3

RTECS 

LT7200000

Hazard Note 

Irritant

HazardClass 

3.2

PackingGroup 

III

HS Code 

29321900

Hazardous Substances Data

698-63-5(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

5-Nitrofurfural Chemical Properties,Usage,Production

Description

Nitrofuran carboxaldehyde (NFC) is used to synthesize many drugs and chemicals such as nifuraldezone, puraguanidine, nifuratrone, furmethoxadone, etc. Furfural the main structure of NFC was determined many years ago to be a byproduct of formic acid synthesis. Furfural is produced from agricultural byproducts such as sugarcane bagasse and corncobs.

Chemical Properties

Yellow to brown crystalline low melting solid

Uses

NFC and its derivatives have antibacterial and antifungal activities. They destroy both gram-positive and gram-negative organisms such as Staphylococcus aureus, Salmonella schotmuelleri, Pseudomonas aeruginosa, Proteus vulgaris, Escherichia coli, and Streptococcus pyogenes. They may be used as antibacterial agents in a prophylactic manner, for example, in cleaning and disinfecting products. This compound also has antitrichomonal and antifungal activities.

Uses

5-Nitro-2-furaldehyde was used in the synthesis of a series of 4-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives. . It was also used in the synthesis of modified mesoporous silica (MCM-41). 5-Nitrofurfural can be commonly used as pharmaceutical intermediates.

Definition

ChEBI: 5-Nitrofurfural is a C-nitro compound and a member of furans.

Production Methods

Furfural is nitrated in acetic anhydride solution at 25 – 40 ℃ to give the diacetate [92-55-7], which is purified by recrystallization from isopropanol and then used directly for the production of derived drugs.

Toxicity evaluation

NFC inhibits the uptake of oxygen and disrupts cellular respiration within mitochondria. NFC and other nitrofurans are relatively potent inhibitors of monoamine oxidase enzyme in mammalian and avian species.