(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE
- Product Name
- (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE
- CAS No.
- 89031-84-5
- Chemical Name
- (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE
- Synonyms
- cyclohex-1-ene-1-carbaldehyde;DK422;DK947;DKFELEX0253;(3-Bromopropoxy)-tert-butyL;3-BROMOPROPOXY-T-BUTYLDIMETHYLSILANE;3-BroMoethoxy-tert-butyl diMethylsilane;(3-BroMopropoxy)-t-buyl-1-diMethylsilane;(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE;1-Bromo-3-(tert-butyldimethylsiloxy)propane
- CBNumber
- CB2727693
- Molecular Formula
- C9H21BrOSi
- Formula Weight
- 253.25
- MOL File
- 89031-84-5.mol
(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE Property
- Boiling point:
- 182 °C(lit.)
- Density
- 1.093 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.451(lit.)
- Flash point:
- 185 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly)
- form
- Oil
- color
- Colourless
- InChIKey
- QGMROEZDWJTIDW-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 429066
- Product name
- (3-Bromopropoxy)-tert-butyldimethylsilane
- Purity
- 97%
- Packaging
- 5ml
- Price
- $80.5
- Updated
- 2025/07/31
- Product number
- 429066
- Product name
- (3-Bromopropoxy)-tert-butyldimethylsilane
- Purity
- 97%
- Packaging
- 25ml
- Price
- $423
- Updated
- 2025/07/31
- Product number
- B5346
- Product name
- (3-Bromopropoxy)(tert-butyl)dimethylsilane
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $85
- Updated
- 2025/07/31
- Product number
- B5346
- Product name
- (3-Bromopropoxy)(tert-butyl)dimethylsilane
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $292
- Updated
- 2025/07/31
- Product number
- B687710
- Product name
- (3-Bromopropoxy)-tert-butyldimethylsilane
- Packaging
- 25g
- Price
- $250
- Updated
- 2021/12/16
(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE Chemical Properties,Usage,Production
Uses
The propanol functionality of this versatile reagent can be introduced to many pharmaceuticals.1,2,3,4
Uses
(3-Bromopropoxy)-tert-butyldimethylsilane may be used to introduce propanol functionality to many pharmaceuticals.
It may be used as an alkylating agent in the synthesis of the following:
- N-[2-[N-[3-(tert-butyldimethylsilyloxy)propyl]-N-ethylamino]ethyl]phthalimide
- O-(3-tert-butyldimethylsilyloxypropyl)-N-(tert-butoxycarbonyl)-L-tyrosine methyl ester
- tert-butyldimethyl-[3-(3-methyl-2-nitrophenoxy)propoxy]silane
Uses
(3-Bromopropoxy)-tert-butyldimethylsilane is a reagent in the preparation of piperidinylcarbonyl sulfamates as a novel class of antihyperlipidemic agents with LDL-receptor up-regulation via the adaptor protein autosomal recessive hypercholesterolemia.
General Description
(3-Bromopropoxy)-tert-butyldimethylsilane is a bromo silyl ether.
Synthesis
18162-48-6
627-18-9
89031-84-5
Example C: Synthesis of 3-(3-(2,5-dioxo-4-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)-2-amino-4-methylpentanoic acid propyl ester of 3-bromopropoxy-tert-butyl dimethylsilane. (3-Bromopropoxy)tert-butyldimethylsilane was prepared using the method modified by Galka et al. (J. Lab. Comp. Rad. 2005, 48(11): 797-809). The procedure was as follows: a mixture of 3-bromo-1-propanol (39.1 mmol, 5.43 g), tert-butyldimethylchlorosilane (43.2 mmol, 6.47 g) and imidazole (46.7 mmol, 3.20 g) was stirred and reacted for 3 h at room temperature under inert gas protection. After completion of the reaction, the reaction was quenched with water and the reaction mixture was extracted with diethyl ether. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. Purification by column chromatography (with petroleum ether as eluent) afforded the target product (3-bromopropoxy)tert-butyldimethylsilane (36.4 mmol, 93% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 3.73 (t, 3J = 5.7 Hz, 2H, CH2O), 3.51 (t, 3J = 6.4 Hz, 2H, CH2Br), 2.02 (q, 3J = 5.7 Hz, 3J = 6.4 Hz, 2H, CH2CH2CH2), 0.89 (s, 9H, C( CH3)3), 0.06 (s, 6H, 2×CH3).
References
[1] Heterocycles, 2004, vol. 62, p. 423 - 436
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 14, p. 5080 - 5095
[3] Tetrahedron Letters, 2012, vol. 53, # 36, p. 4805 - 4808
[4] Journal of the American Chemical Society, 2012, vol. 134, # 43, p. 18101 - 18108
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2005, vol. 48, # 11, p. 797 - 809
(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE Preparation Products And Raw materials
Raw materials
Preparation Products
(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE Suppliers
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View Lastest Price from (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE manufacturers
- Product
- 3-Bromopropoxy t-Butyl-Dimethylsilane 89031-84-5
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE 89031-84-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-19
- Product
- (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE 89031-84-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-22