ChemicalBook > CAS DataBase List > (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE

(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE

Product Name: (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE
CAS No.: 89031-84-5
Chemical Name: (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE
Synonyms: cyclohex-1-ene-1-carbaldehyde;DK422;DK947;DKFELEX0253;(3-Bromopropoxy)-tert-butyL;3-BROMOPROPOXY-T-BUTYLDIMETHYLSILANE;3-BroMoethoxy-tert-butyl diMethylsilane;(3-BroMopropoxy)-t-buyl-1-diMethylsilane;(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE;1-Bromo-3-(tert-butyldimethylsiloxy)propane
CBNumber: CB2727693
Molecular Formula: C9H21BrOSi
Formula Weight: 253.25
MOL File: 89031-84-5.mol

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(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE Property

Boiling point:: 182 °C(lit.)
Density: 1.093 g/mL at 25 °C(lit.)
refractive index: n20/D 1.451(lit.)
Flash point:: 185 °F
storage temp.: 2-8°C
solubility: Chloroform (Sparingly)
form: Oil
color: Colourless
InChIKey: QGMROEZDWJTIDW-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
TSCA: No
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 429066
Product name: (3-Bromopropoxy)-tert-butyldimethylsilane
Purity: 97%
Packaging: 5ml
Price: $80.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 429066
Product name: (3-Bromopropoxy)-tert-butyldimethylsilane
Purity: 97%
Packaging: 25ml
Price: $423
Updated: 2025/07/31

TCI Chemical

Product number: B5346
Product name: (3-Bromopropoxy)(tert-butyl)dimethylsilane
Purity: >98.0%(GC)
Packaging: 5g
Price: $85
Updated: 2025/07/31

TCI Chemical

Product number: B5346
Product name: (3-Bromopropoxy)(tert-butyl)dimethylsilane
Purity: >98.0%(GC)
Packaging: 25g
Price: $292
Updated: 2025/07/31

TRC

Product number: B687710
Product name: (3-Bromopropoxy)-tert-butyldimethylsilane
Packaging: 25g
Price: $250
Updated: 2021/12/16

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(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE Chemical Properties,Usage,Production

Uses

The propanol functionality of this versatile reagent can be introduced to many pharmaceuticals.1,2,3,4

Uses

(3-Bromopropoxy)-tert-butyldimethylsilane may be used to introduce propanol functionality to many pharmaceuticals.
It may be used as an alkylating agent in the synthesis of the following:

N-[2-[N-[3-(tert-butyldimethylsilyloxy)propyl]-N-ethylamino]ethyl]phthalimide
O-(3-tert-butyldimethylsilyloxypropyl)-N-(tert-butoxycarbonyl)-L-tyrosine methyl ester
tert-butyldimethyl-[3-(3-methyl-2-nitrophenoxy)propoxy]silane

Uses

(3-Bromopropoxy)-tert-butyldimethylsilane is a reagent in the preparation of piperidinylcarbonyl sulfamates as a novel class of antihyperlipidemic agents with LDL-receptor up-regulation via the adaptor protein autosomal recessive hypercholesterolemia.

General Description

(3-Bromopropoxy)-tert-butyldimethylsilane is a bromo silyl ether.

Synthesis

18162-48-6

627-18-9

89031-84-5

Example C: Synthesis of 3-(3-(2,5-dioxo-4-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)-2-amino-4-methylpentanoic acid propyl ester of 3-bromopropoxy-tert-butyl dimethylsilane. (3-Bromopropoxy)tert-butyldimethylsilane was prepared using the method modified by Galka et al. (J. Lab. Comp. Rad. 2005, 48(11): 797-809). The procedure was as follows: a mixture of 3-bromo-1-propanol (39.1 mmol, 5.43 g), tert-butyldimethylchlorosilane (43.2 mmol, 6.47 g) and imidazole (46.7 mmol, 3.20 g) was stirred and reacted for 3 h at room temperature under inert gas protection. After completion of the reaction, the reaction was quenched with water and the reaction mixture was extracted with diethyl ether. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. Purification by column chromatography (with petroleum ether as eluent) afforded the target product (3-bromopropoxy)tert-butyldimethylsilane (36.4 mmol, 93% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 3.73 (t, 3J = 5.7 Hz, 2H, CH2O), 3.51 (t, 3J = 6.4 Hz, 2H, CH2Br), 2.02 (q, 3J = 5.7 Hz, 3J = 6.4 Hz, 2H, CH2CH2CH2), 0.89 (s, 9H, C( CH3)3), 0.06 (s, 6H, 2×CH3).

References

[1] Heterocycles, 2004, vol. 62, p. 423 - 436
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 14, p. 5080 - 5095
[3] Tetrahedron Letters, 2012, vol. 53, # 36, p. 4805 - 4808
[4] Journal of the American Chemical Society, 2012, vol. 134, # 43, p. 18101 - 18108
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2005, vol. 48, # 11, p. 797 - 809

(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE Preparation Products And Raw materials

Raw materials

Preparation Products

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(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE Suppliers

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View Lastest Price from (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-Bromopropoxy t-Butyl-Dimethylsilane 89031-84-5
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Shaanxi Dideu New Materials Co. Ltd

Product: (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE 89031-84-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-19

Hebei Chuanghai Biotechnology Co., Ltd

Product: (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE 89031-84-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-22

89031-84-5, (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANERelated Search:

T-BUTYLDIMETHYLSILANE TRANS-3-BROMO-5-TERT-BUTYL-DIMETHYLSILYLOXY-2-PENTEN-1-OL (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE

3-BROMOPROPOXY-T-BUTYLDIMETHYLSILANE

(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE

93-Bromopropoxy)-tert-butyldimethylsilane(Na2CO3 stabiliszer)975

Silane,(3-bromopropoxy)(1,1-dimethylethyl)dimethyl-

3-BroMoethoxy-tert-butyl diMethylsilane

(3-BroMopropoxy)-tert-butyldiMethylsilane, 97%, stabilized over sodiuM carbonate

(3-BroMopropoxy)-t-buyl-1-diMethylsilane

(3-Bromopropoxy)-tert-butyldimethylsilane 97%

1-Bromo-3-(tert-butyldimethylsiloxy)propane

cyclohex-1-ene-1-carbaldehyde

(3-Bromopropoxy)-tert-butyL

DK422

DK947

DKFELEX0253

(3-Bromopropoxy)-<i>tert</i>-butyldimethylsilane

89031-84-5

BrCH23OSiCH32CCH33

C9H21BrOSi

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