ChemicalBook > CAS DataBase List > BACE-1
BACE-1
- Product Name
- BACE-1
- CAS No.
- 158736-49-3
- Chemical Name
- BACE-1
- Synonyms
- ASP-2;BACE-1;HSPC104;MEMAPSIN-2;B-SECRETASE;HUMAN BACE-1;β-Secretase human;HUMAN BETA-SECRETASE;BETA-SECRETASE HUMAN;BETA-SECRETASE ENZYME
- CBNumber
- CB2730309
- Formula Weight
- 0
- MOL File
- Mol file
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BACE-1 Property
- storage temp.
- 2-8°C
- form
- buffered aqueous solution
- Specific Activity
- ≥10,000units/mg protein
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- S4195
- Product name
- β-Secretase human
- Purity
- recombinant, expressed in HEK 293 cells (C-terminal FLAG tagged), ≥10,000 units/mg protei
- Packaging
- 50 μg
- Price
- $371.05
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- S4195
- Product name
- β-Secretase human
- Purity
- recombinant, expressed in HEK 293 cells (C-terminal FLAG tagged), extracellular domain, ≥10,000?units/mg protein, ≥90% (SDS-PAGE), buffered aqueous solution
- Packaging
- 50μG
- Price
- $373
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- SAB2900193
- Product name
- Anti-BACE1 (AB1) antibody produced in rabbit
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 50μg
- Price
- $599
- Updated
- 2022/05/15
Usbiological
- Product number
- 354173
- Product name
- BACE1
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
Usbiological
- Product number
- 354172
- Product name
- BACE1
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
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BACE-1 Chemical Properties,Usage,Production
Uses
Human β-secretase or BACE1 has been used to study the binding reaction between amyloid precursor protein and β-secretase. It has also been used in BACE1 assay.
Biochem/physiol Actions
BACE1 (β-site APP-cleaving enzyme 1) is a transmembrane aspartyl protease responsible for cleaving the amyloid precursor protein (APP). BACE1-mediated cleavage of amyloid precursor protein (APP) is the first step during the generation of pathogenic amyloid-β peptides, hence making it the major drug target for Alzheimer′s disease (AD). Increased levels of enzymatic activity of BACE1 was found in cerebrospinal fluid from patients having both mild cognitive impairment (MCI) and AD, thereby suggesting the importance of BACE1 enzymatic activity in conversion of MCI to AD.
BACE-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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