ChemicalBook > CAS DataBase List > 3-(2-HYDROXY-2-PROPYL)PHENOL

3-(2-HYDROXY-2-PROPYL)PHENOL

Product Name
3-(2-HYDROXY-2-PROPYL)PHENOL
CAS No.
7765-97-1
Chemical Name
3-(2-HYDROXY-2-PROPYL)PHENOL
Synonyms
M-HYDROXYCUMYL ALCOHOL;3-(2-HYDROXY-2-PROPYL)PHENOL;3-(2-Hydroxypropan-2-yl)phenol;3-Hydroxy-a,a-dimethylbenzenemethanol;3-Hydroxy-α,α-dimethylbenzenemethanol;Benzenemethanol, 3-hydroxy-α,α-dimethyl-
CBNumber
CB2730602
Molecular Formula
C9H12O2
Formula Weight
152.19
MOL File
7765-97-1.mol
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3-(2-HYDROXY-2-PROPYL)PHENOL Property

Melting point:
105-106 °C
Boiling point:
288.2±15.0 °C(Predicted)
Density 
1.122±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
9.94±0.10(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
H962130
Product name
3-(2-Hydroxypropan-2-yl)phenol
Packaging
1g
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0009614
Product name
3-(2-HYDROXY-2-PROPYL)PHENOL
Purity
95.00%
Packaging
5MG
Price
$500.75
Updated
2021/12/16
AK Scientific
Product number
Z5119
Product name
3-(2-Hydroxypropan-2-yl)phenol
Packaging
1g
Price
$587
Updated
2021/12/16
Matrix Scientific
Product number
126339
Product name
3-(2-Hydroxypropan-2-yl)phenol
Purity
>95%
Packaging
1g
Price
$1044
Updated
2021/12/16
Crysdot
Product number
CD12031692
Product name
3-(2-Hydroxypropan-2-yl)phenol
Purity
96%
Packaging
100mg
Price
$105
Updated
2021/12/16
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3-(2-HYDROXY-2-PROPYL)PHENOL Chemical Properties,Usage,Production

Uses

3-(2-Hydroxypropan-2-yl)phenol is an intermediate in the preparation of DDAO (D195160).

Synthesis

19438-10-9

676-58-4

7765-97-1

Step 1: Synthesis of INT-04 Methyl 3-hydroxybenzoate (2.0 g, 13.3 mmol) was dissolved in THF (10 mL) under argon protection and slowly added dropwise at room temperature to a THF solution of 1 M methyl magnesium chloride (30 mL, 30.6 mmol). After the dropwise addition was completed, the reaction continued to be stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution and subsequently extracted with EtOAc (2 x 15 mL). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 20% EtOAc/hexane) to afford 3-(2-hydroxypropan-2-yl)phenol (INT-04) (1.45 g, 72.5% yield) in colorless liquid form; Rf value of 0.5 by TLC (Expanding agent: 20% EtOAc/hexane).

References

[1] Patent: WO2015/106164, 2015, A1. Location in patent: Page/Page column 65
[2] Patent: US2017/66791, 2017, A1. Location in patent: Paragraph 0348; 0349

3-(2-HYDROXY-2-PROPYL)PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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