3-(2-HYDROXY-2-PROPYL)PHENOL
- Product Name
- 3-(2-HYDROXY-2-PROPYL)PHENOL
- CAS No.
- 7765-97-1
- Chemical Name
- 3-(2-HYDROXY-2-PROPYL)PHENOL
- Synonyms
- M-HYDROXYCUMYL ALCOHOL;3-(2-HYDROXY-2-PROPYL)PHENOL;3-(2-Hydroxypropan-2-yl)phenol;3-Hydroxy-a,a-dimethylbenzenemethanol;3-Hydroxy-α,α-dimethylbenzenemethanol;Benzenemethanol, 3-hydroxy-α,α-dimethyl-
- CBNumber
- CB2730602
- Molecular Formula
- C9H12O2
- Formula Weight
- 152.19
- MOL File
- 7765-97-1.mol
3-(2-HYDROXY-2-PROPYL)PHENOL Property
- Melting point:
- 105-106 °C
- Boiling point:
- 288.2±15.0 °C(Predicted)
- Density
- 1.122±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 9.94±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- H962130
- Product name
- 3-(2-Hydroxypropan-2-yl)phenol
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CHM0009614
- Product name
- 3-(2-HYDROXY-2-PROPYL)PHENOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.75
- Updated
- 2021/12/16
- Product number
- Z5119
- Product name
- 3-(2-Hydroxypropan-2-yl)phenol
- Packaging
- 1g
- Price
- $587
- Updated
- 2021/12/16
- Product number
- 126339
- Product name
- 3-(2-Hydroxypropan-2-yl)phenol
- Purity
- >95%
- Packaging
- 1g
- Price
- $1044
- Updated
- 2021/12/16
- Product number
- CD12031692
- Product name
- 3-(2-Hydroxypropan-2-yl)phenol
- Purity
- 96%
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
3-(2-HYDROXY-2-PROPYL)PHENOL Chemical Properties,Usage,Production
Uses
3-(2-Hydroxypropan-2-yl)phenol is an intermediate in the preparation of DDAO (D195160).
Synthesis
19438-10-9
676-58-4
7765-97-1
Step 1: Synthesis of INT-04 Methyl 3-hydroxybenzoate (2.0 g, 13.3 mmol) was dissolved in THF (10 mL) under argon protection and slowly added dropwise at room temperature to a THF solution of 1 M methyl magnesium chloride (30 mL, 30.6 mmol). After the dropwise addition was completed, the reaction continued to be stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution and subsequently extracted with EtOAc (2 x 15 mL). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 20% EtOAc/hexane) to afford 3-(2-hydroxypropan-2-yl)phenol (INT-04) (1.45 g, 72.5% yield) in colorless liquid form; Rf value of 0.5 by TLC (Expanding agent: 20% EtOAc/hexane).
References
[1] Patent: WO2015/106164, 2015, A1. Location in patent: Page/Page column 65
[2] Patent: US2017/66791, 2017, A1. Location in patent: Paragraph 0348; 0349
3-(2-HYDROXY-2-PROPYL)PHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
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