D-(+)-NEOPTERIN

ChemicalBook > CAS DataBase List > D-(+)-NEOPTERIN

Product Name: D-(+)-NEOPTERIN
CAS No.: 2009-64-5
Chemical Name: D-(+)-NEOPTERIN
Synonyms: NEOPTERIN;(+)-NEOPTERIN;2-Amino-6-((1S;D-erythro-Form;D-(+)-NEOPTERIN;Neopterin (7CI);D(+)-Neopterin,99%;D-(PLUS)-NEOPTERINE;D-ERYTHRO-NEOPTERIN;D(+)-Neopterin, 99% 10MG
CBNumber: CB2734079
Molecular Formula: C9H11N5O4
Formula Weight: 253.21
MOL File: 2009-64-5.mol

Less

D-(+)-NEOPTERIN Property

Melting point:: >232°C (dec.)
alpha: D25 +45 ± 3° (c = 0.3 in 0.1N HCl)
Boiling point:: 396.41°C (rough estimate)
Density: 1.3957 (rough estimate)
refractive index: 1.7610 (estimate)
storage temp.: 2-8°C
solubility: Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly)
form: Off-white to yellow solid.
pka: 12.60±0.20(Predicted)
color: Light Orange to Light Brown
Merck: 13,6490
BRN: 89070
Stability:: Hygroscopic
InChIKey: BMQYVXCPAOLZOK-XINAWCOVSA-N

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
F: 23
HS Code: 29335990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N3386
Product name: D-(+)-Neopterin
Purity: ≥97.5% (sum of enantiomers, HPLC)
Packaging: 10mg
Price: $76
Updated: 2024/03/01

Sigma-Aldrich

Product number: N3386
Product name: D-(+)-Neopterin
Purity: ≥97.5% (sum of enantiomers, HPLC)
Packaging: 25mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 12057
Product name: Neopterin
Purity: ≥98%
Packaging: 10mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 12057
Product name: D-Neopterin
Purity: ≥98%
Packaging: 25mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 12057
Product name: Neopterin
Purity: ≥98%
Packaging: 50mg
Price: $117
Updated: 2024/03/01

Less

D-(+)-NEOPTERIN Chemical Properties,Usage,Production

Description

Neopterin is a pyrazino-pyrimidine compound derived from GTP that represents an intermediate product in the synthetic pathway of biopterin and is an essential cofactor in neurotransmitter synthesis. Neopterin is released from macrophages upon immune stimulation with interferon-γ from activated T cells. It is routinely used as a biochemical tool to screen for and monitor the progression of certain diseases accompanied by hyperimmune stimulation.

Chemical Properties

off-white to yellow solid

Uses

Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.

Uses

D-(+)-Neopterin has been used as a NADPH oxidase inhibitor while assessing the ability of NADPH oxidases in breast cancer cells to produce reactive oxygen species (ROS). [NADPH= nicotinamide adenine dinucleotide phosphate]

General Description

D-(+)-Neopterin is a pteridine derivative, naturally found in Dictyostelium discoideum. It is found in significant amounts in the urine of cancer patients.

Biochem/physiol Actions

Pterin cofactor; precursor of BH4 (tetrahydrobiopterin).

storage

Store at -20°C

Purification Methods

Purification is as for biopterin. Also purify it on a Dowex-1 x 8 (formate form) column and elute with 0.03M ammonium formate buffer pH 8.0 then pH 7.2. The fluorescent neopterin fraction is evaporated under reduced pressure, leaving neopterin and ammonium formate (the latter sublimes out at high vacuum) behind. Stir the residue for 24hours with EtOH, collect the solid and recrystallise it from H2O. [Viscontini et al. Helv Chim Acta 53 1202 1970, cf Wachter et al. Eds Neopterin W de Gruyter, Berlin 1992, ISBN 9783110117905, Beilstein 26 IV 4038.]

D-(+)-NEOPTERIN Preparation Products And Raw materials

Raw materials

Preparation Products

Less

D-(+)-NEOPTERIN Suppliers

Belgium 1 Canada 1 China 81 Germany 1 India 2 Japan 1 Switzerland 2 United Kingdom 2 United States 17 USA 1 Global 109

Guangzhou Ku Wei Biological Technology Co., Ltd

Tel: 15013362837
Fax: 020-61063208
Email: yxusmith@aliyun.com
Country: China
ProdList: 9
Advantage: 52

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7887
Advantage: 56

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11578
Advantage: 59

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28806
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19800
Advantage: 60

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10330
Advantage: 58

Aikon International Limited

Tel: 025-66113011 18112977050
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 15497
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-010-010-62971590 18548936886
Fax: 010-62340519
Email: jack@oka-vip.com
Country: China
ProdList: 6897
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

Zhengzhou Alfa Chemical Co.,Ltd

Tel: +8618530059196
Email: sale04@alfachem.cn
Country: China
ProdList: 11840
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15352
Advantage: 58

Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd

Tel: 027-83855382 15926260338
Email: 15926260338@163.com
Country: China
ProdList: 2030
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd

Tel: +86-13522808617 +86-13522808617
Email: omichem@126.com
Country: China
ProdList: 9211
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9989
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Lingyuan Bebiansen Biological Technology Co., Ltd

Tel: 18642120371
Email: 2837458851@qq.com
Country: China
ProdList: 7995
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 8084
Advantage: 58

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-59308705 18871579363
Fax: 027-59308705
Email: 1248680011@qq.com
Country: China
ProdList: 9950
Advantage: 58

Hubei Guangao Biotechnology Co., Ltd

Tel: 027-027-59223056 18162699093
Fax: 027-59223056
Email: 1208480011@qq.com
Country: China
ProdList: 9924
Advantage: 58

Tianmen Hengchang Chemical Co., Ltd

Tel: 027-59322316 15172518801
Fax: 027-59322316
Email: 1208480077@qq.com
Country: China
ProdList: 9895
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31121
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 0519-88910898 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 9996
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: 0755-66853366; 13670046396
Email: ORDERS@QCSRM.COM
Country: China
ProdList: 24342
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62075
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9959
Advantage: 58

Henan Evonik Biotechnology Co. LTD

Tel: 16650615803
Email: hnyingchuang@163.com
Country: China
ProdList: 3912
Advantage: 58

Shanghai Yingxin Laboratory Equipment Co., Ltd.

Tel: 021-021-59178156 17002132182
Email: 3146474380@qq.com
Country: China
ProdList: 11603
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

2009-64-5, D-(+)-NEOPTERINRelated Search:

Pyrazine ANTI-NEOPTERIN (6R)-Heptaacetyl-5-ethyl-5,6,7,8-tetrahydro-D-neopterin NEOPTERIN NEOPTERIN ELISA KIT 96 WELLS NEOPTERIN, 7,8-DIHYDRO-D,7,8-DIHYDRO-D-NEOPTERIN (-)-L-Neopterin,L-Neopterin,L-erythro-Neopterin neopterin-3'-triphosphate 4-HYDROXYPTERIDINE 2-Pyrazinylmethanol 2-Propylpyrazine 2-(2'-HYDROXYETHYL)PYRAZINE D-(+)-NEOPTERIN Neopterin

(+)-NEOPTERIN

2-Amino-6-((1S

3-trihydroxypropyl)pteridin-4(3H)-one

2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone

NEOPTERIN

D-(+)-NEOPTERIN

D(+)-6-(ERYTHRO-1,2,3-TRIHYDROXYPROPYL)PTERIN

D-ERYTHRO-NEOPTERIN

[S-(R*,S*)]-2-amino-6-(1,2,3-trihydroxypropyl)-1H-pteridin-4-one

D-(PLUS)-NEOPTERINE

1-(2-amino-4-hydroxy-pteridin-6-yl)propane-1,2,3-triol

2-Amino-6-[(1R,2S)-1,2,3-trihydroxypropyl]pteridin-4(1H)-one

D(+)-Neopterin,99%

D(+)-Neopterin, 99% 10MG

2-AMino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-

D-(+)-Neopterin >=97.5% (suM of enantioMers, HPLC)

D-erythro-Form

D-Neopterin [D-erythro-Neopterin]

2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)pteridin-4(3H)-one

4(3H)-Pteridinone, 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-

Neopterin (7CI)

inhibit,Endogenous Metabolite,Inhibitor,Neopterin

Sapropterin Impurity 22 (D-Neopterin)

2009-64-5

Chiral Building Blocks

Asymmetric Synthesis

Heterocyclic Building Blocks

Others

Bases & Related Reagents

Heterocycles

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals