2-Propylpyrazine
Application- Product Name
- 2-Propylpyrazine
- CAS No.
- 18138-03-9
- Chemical Name
- 2-Propylpyrazine
- Synonyms
- propylpyrazine;propyl-pyrazin;N-PROPYLPYRAZINE;FEMA NUMBER 3961;2-PROPYLPYRAZINE;Pyrazine, propyl-;2-N-PROPYLPYRAZINE;2-Propylpyrazine>Pyrazine, 2-propyl-;2-Propylpyrazine ,97%
- CBNumber
- CB7439173
- Molecular Formula
- C7H10N2
- Formula Weight
- 122.17
- MOL File
- 18138-03-9.mol
2-Propylpyrazine Property
- Boiling point:
- 65 °C (12 mmHg)
- Density
- 0.975
- refractive index
- 1.492-1.494
- FEMA
- 3961 | PROPYLPYRAZINE
- Flash point:
- 56 °C
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 1.70±0.10(Predicted)
- color
- Colorless to Light yellow
- Specific Gravity
- 0.9700
- Odor
- at 0.10 % in dipropylene glycol. green vegetable nutty
- Odor Type
- green
- JECFA Number
- 763
- LogP
- 1.24
- CAS DataBase Reference
- 18138-03-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyrazine, 2-(n-propyl)-(18138-03-9)
- EPA Substance Registry System
- Pyrazine, propyl- (18138-03-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 37/38-41-36/37/38
- Safety Statements
- 24/25-39-26-36
- RIDADR
- UN 1993C 3 / PGIII
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P1833
- Product name
- 2-Propylpyrazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $76
- Updated
- 2025/07/31
- Product number
- 006664
- Product name
- n-Propylpyrazine
- Purity
- 97%
- Packaging
- 5g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 43569
- Product name
- 2-Propylpyrazine,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 5G
- Price
- $86.66
- Updated
- 2021/12/16
- Product number
- OR939928
- Product name
- 2-Propylpyrazine
- Purity
- 95%
- Packaging
- 10g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 006664
- Product name
- n-Propylpyrazine
- Purity
- 97%
- Packaging
- 25g
- Price
- $119
- Updated
- 2021/12/16
2-Propylpyrazine Chemical Properties,Usage,Production
Application
2-Propylpyrazine is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.
Chemical Properties
clear very slightly yellow liquid
Chemical Properties
2-Propylpyrazine has a green, vegetable odor.
Occurrence
Reported found in roasted coffee beans.
Definition
ChEBI: Propylpyrazine is a member of pyrazines.
Aroma threshold values
Detection: 300 ppb
Synthesis
14508-49-7
2234-82-4
18138-03-9
The general procedure for the synthesis of 2-propylpyrazine from 2-chloropyrazine and propylmagnesium chloride was as follows: first, 8.0 mL of 2-chloropyrazine, 1.58 g of iron acetylacetonate (Fe(acac)3), and 100 mL of tetrahydrofuran (THF) were added to a stirred round-bottomed flask. The mixture was stirred under nitrogen protection to form a red solution. The flask was cooled in an ice water bath for 10 minutes. Subsequently, 49 mL of n-propylmagnesium chloride was slowly added and the solution turned dark purple. After 1.5 hours of reaction, an additional 10 mL of n-propylmagnesium chloride was added over 10 minutes. after 20 minutes, 5 mL of n-propylmagnesium chloride continued to be added. After stirring for about 30 minutes, 22 mL of saturated aqueous ammonium chloride (NH4Cl) was added over 7 minutes. After an additional 7 mL of NH4Cl was added, stirring was stopped and the mixture was allowed to stand at room temperature under nitrogen protection overnight. After addition of 125 mL of ethyl acetate (EtOAc) and 450 mL of water, the mixture was filtered through a polypropylene filter and transferred to a partition funnel. The organic and aqueous phases were separated and the aqueous phase was extracted twice with 125 mL of EtOAc. The organic phase was combined and filtered through Celite. Subsequently, it was concentrated using a rotary evaporator at 200 mbar and 40 °C. The fractions were purified by short-range distillation and Vigreux column distillation (200 mbar, 90-110 °C) to give 9.0 g (82.4% yield) of 2-n-propylpyrazine. The purity of the final product was confirmed by HPLC analysis using an Elipse XDB-C8 column (4.6 × 150 mm, 5 μm) with a mobile phase of 60:40 acetonitrile/water (containing 1% trifluoroacetic acid) at a flow rate of 1 mL/min, a column temperature of 35 °C, and a retention time of 3.0 minutes.
References
[1] Patent: WO2010/107969, 2010, A1. Location in patent: Page/Page column 6-7
[2] Journal of the American Chemical Society, 1992, vol. 114, # 13, p. 5269 - 5280
[3] Organic Process Research and Development, 2015, vol. 19, # 7, p. 806 - 811
2-Propylpyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Propylpyrazine manufacturers
- Product
- 2-Propylpyrazine 18138-03-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-12
- Product
- 2-n-propylpyrazine 18138-03-9
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-19
- Product
- 2-Propylpyrazine 18138-03-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10ton
- Release date
- 2024-07-17