6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE

Product Name: 6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
CAS No.: 34334-69-5
Chemical Name: 6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
Synonyms: CIRSILIOL;Crisiliol;Cirsiliol - Bio-X ?;Cirsiliol >=95% (HPLC);3'-Hydroxy-6-methoxygenkwanin;3',4',5-Trihydroxy-6,7-dimethoxy;6-Methoxyluteolin 7-methyl ether;6-Hydroxyluteolin-6,7-dimethyl ether;6,7-DIMETHOXY-5,3',4'-TRIHYDROXYFLAVONE;6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
CBNumber: CB2736583
Molecular Formula: C17H14O7
Formula Weight: 330.29
MOL File: 34334-69-5.mol

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6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Property

Melting point:: 280-281.5℃ (methanol )
Boiling point:: 616.1±55.0 °C(Predicted)
Density: 1.483±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Acetone: soluble; Chloroform: soluble; DMSO: soluble
pka: 6.31±0.40(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3
RTECS: DJ3011100

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0953
Product name: Cirsiliol
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $103
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0953
Product name: Cirsiliol
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $417
Updated: 2025/07/31

TRC

Product number: D476383
Product name: 6,7-Dimethoxy-3'',4'',5-trihydroxyflavone
Packaging: 1mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD66719
Product name: 6,7-Dimethoxy-3',4',5-trihydroxyflavone
Packaging: 5mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD66719
Product name: 6,7-Dimethoxy-3',4',5-trihydroxyflavone
Packaging: 10mg
Price: $100
Updated: 2021/12/16

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6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Chemical Properties,Usage,Production

Uses

Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.

Definition

ChEBI: A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5, 3' and 4' respectively.

Biological Activity

Cirsiliol is a flavonoid th at displays anti-inflammatory, anti-oxidant, anti-proliferative, and anti-bacterial activities. Cirsiliol sensitizes non-small cell lung cancer cell lines (NSCLC) to radiation therapy. Cirsiliol inhibits epithelial-mesenchymal transition likely by induction of tumor-suppressive miR-34a, which suppresses Notch-1 expression NSCLC.

in vivo

In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone^[2].

IC 50

5-Lipoxygenase

References

[1] Mustafa EH, et al. Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum. Gen Pharmacol. 1992 May;23(3):555-60. DOI:10.1016/0306-3623(92)90127-6
[2] Kang J, et al. Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. J Biol Chem. 2013 Sep 20;288(38):27343-57. DOI:10.1074/jbc.M113.490482

6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Suppliers

China 70 Germany 2 India 1 United Kingdom 5 United States 12 Global 90

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Shanghai SuperLan Chemcial Technique Centre

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34334-69-5, 6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONERelated Search:

6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE CASTICIN 3',4',5',5,6,7-HEXAMETHOXYFLAVONE Nobiletin ARTEMETIN EUPATORIN-5-METHYL ETHER 3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE 5-DEMETHYLNOBILETIN 3,5-DIMETHOXY-7,3',4'-TRIHYDROXYFLAVONE cirsilineol 6,7-Dimethoxy-3,5,4'-trihydroxyflavone Tricin 3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE,3,4'-DIMETHOXY-5,7,3'-TRIHYDROXYFLAVONE Jaceosidin 5,3',4'-trihydroxy-3,6,7,8-tetramethoxyflavone SINENSETIN

CIRSILIOL

6,7-DIMETHOXY-3,4'',5-TRIHYDROXYFLAVONE 95+%

3'-Hydroxy-6-methoxygenkwanin

6-Hydroxyluteolin-6,7-dimethyl ether

6-Methoxyluteolin 7-methyl ether

Crisiliol

6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE

6,7-DIMETHOXY-5,3',4'-TRIHYDROXYFLAVONE

3',4',5-Trihydroxy-6,7-dimethoxy

Cirsiliol >=95% (HPLC)

2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-

Cirsiliol - Bio-X ?

34334-69-5

Flavones