cirsilineol

Product Name: cirsilineol
CAS No.: 41365-32-6
Chemical Name: cirsilineol
Synonyms: Eupatrin;Anisomelin;NSC 633556;Fastigenin;cirsilineol;Cirsilineol-RM;6-Methoxyluteolin 3',7-dimethyl ether;5,4'-Dihydroxy-6,7,3'-trimethoxyflavone;4',5-Dihydroxy-3',6,7-trimethoxyflavone;4',5-Dihydroxy 3',6,7-trimethoxyflavone
CBNumber: CB91387604
Molecular Formula: C18H16O7
Formula Weight: 344.32
MOL File: 41365-32-6.mol

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cirsilineol Property

Melting point:: 147 °C(Solv: benzene (71-43-2))
Boiling point:: 585.0±50.0 °C(Predicted)
Density: 1.387
storage temp.: -20°C
solubility: Soluble in DMSO, ethanol and water;
pka: 6.31±0.40(Predicted)
form: Solid
color: Yellow
Water Solubility: insoluble in water
BRN: 1355108
InChI: InChI=1S/C18H16O7/c1-22-13-6-9(4-5-10(13)19)12-7-11(20)16-14(25-12)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3
InChIKey: VKOSQMWSWLZQPA-UHFFFAOYSA-N
SMILES: C1(C2=CC=C(O)C(OC)=C2)OC2=CC(OC)=C(OC)C(O)=C2C(=O)C=1
LogP: 1.670 (est)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 67403
Product name: Cirsilineol
Purity: analytical standard
Packaging: 5mg
Price: $989
Updated: 2022/05/15

American Custom Chemicals Corporation

Product number: PXT0001062
Product name: 4',5-DIHYDROXY-3',6,7-TRIMETHOXYFLAVONE
Purity: 95.00%
Packaging: 5MG
Price: $500.42
Updated: 2021/12/16

Arctom

Product number: CFN90418
Product name: Cirsilineol
Packaging: 5mg
Price: $468
Updated: 2021/12/16

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cirsilineol Chemical Properties,Usage,Production

Uses

Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice[1].

Definition

ChEBI: A trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7 and 3' and hydroxy groups at positions 5 and 4' respectively.

in vivo

cirsilineol (3, 10, and 30 mg/kg) significantly ameliorates TNBS-induced Th1-mediated colitis through inhibiting IFN-γ/STAT1/T-bet signaling in CD4⁺ T cells.

Animal Model:	8-10-week-old female C57BL/6, BALB/c and DO11.10 transgenic mice with TNBS (10 mg; 100 μL)^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	IP; daily; for 11 days
Result:	Showed a significant improved effect on the body weights and survival rate of mice. Markedly reduced inflammatory infiltration, restoration of the destructive mucosal architecture and remission of edema.

target

References

[1] Yang Sun, et al. Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease. Biochem Pharmacol. 2010 Jan 15;79(2):229-38. DOI:10.1016/j.bcp.2009.08.014

cirsilineol Preparation Products And Raw materials

Raw materials

Preparation Products

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cirsilineol Suppliers

China 48 India 1 South Korea 1 United States 8 Global 58

Huzhou ZhanShu Biotechnology Co.,Ltd

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Chembest Research Laboratories Limited

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Sichuan Wei Keqi Biological Technology Co., Ltd.

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Wuxi Zhongkun Biochemical Technology Co., Ltd.

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Wuhan ChemFaces Biochemical Co., Ltd.

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EMMX Biotechnology LLC

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai ChengShao Biological Technology Co., Ltd.

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Chengdu Push Bio-Technology Co., Ltd.

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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41365-32-6, cirsilineolRelated Search:

6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE

cirsilineol

2-(4-Hydroxy-3-methoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one

4',5-Dihydroxy-3',6,7-trimethoxyflavone

5,4'-Dihydroxy-6,7,3'-trimethoxyflavone

5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one

Anisomelin

6-Methoxyluteolin 3',7-dimethyl ether

Eupatrin

Fastigenin

NSC 633556

4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-

4',5-Dihydroxy 3',6,7-trimethoxyflavone

Cirsilineol-RM

41365-32-6