1-Boc-3-hydroxymethylpyrrolidine
- Product Name
- 1-Boc-3-hydroxymethylpyrrolidine
- CAS No.
- 114214-69-6
- Chemical Name
- 1-Boc-3-hydroxymethylpyrrolidine
- Synonyms
- N-Boc-DL-beta-prolinol;N-Boc-DL-^b-prolinol, 97+%;1-Boc-3-(hydroxyMethyl)py...;N-Boc-DL-beta-prolinol, 97+%;1-BOC-3-Pyrrolidinemethanol 97%;1-BOC-3-HYDROXYMETHYLPYRROLIDINE;N-BOC--3-hydrozyMethyl-pyrroidine;3-HYDROXYMETHYL-1-BOC-PYRROLIDINE;N-Boc-3-(hydroxymethyl)pyrrolidine;1-BOC-3-Hydroxymethyl-1H-pyrrolidine
- CBNumber
- CB2737227
- Molecular Formula
- C10H19NO3
- Formula Weight
- 201.26
- MOL File
- 114214-69-6.mol
1-Boc-3-hydroxymethylpyrrolidine Property
- Boiling point:
- 285-291℃
- Density
- 1.089
- refractive index
- 1.4680 to 1.4720
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 14.93±0.10(Predicted)
- color
- Colorless to Light orange to Yellow
- InChI
- InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h8,12H,4-7H2,1-3H3
- InChIKey
- HKIGXXRMJFUUKV-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(CO)C1
- CAS DataBase Reference
- 114214-69-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,N,T
- Risk Statements
- 25-50
- Safety Statements
- 24/25-61-45
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- ADE000016
- Product name
- 3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- B4249
- Product name
- 1-(tert-Butoxycarbonyl)-3-pyrrolidinemethanol
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $124
- Updated
- 2025/07/31
- Product number
- B4249
- Product name
- 1-(tert-Butoxycarbonyl)-3-pyrrolidinemethanol
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $369
- Updated
- 2025/07/31
- Product number
- B656678
- Product name
- 1-Boc-3-hydroxymethylpyrrolidine
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 228681
- Product name
- 1-Boc-3-hydroxymethylpyrrolidine
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
1-Boc-3-hydroxymethylpyrrolidine Chemical Properties,Usage,Production
Uses
1-Boc-3-hydroxymethylpyrrolidine is an intermediate of SR 9009 (S684255). SR 9009 is a synthetic REV-ERB agonist that regulates circadian behavior and metabolism; has potential use in the treatment of sleep disorders and metabolic diseases.
Synthesis
85310-69-6
24424-99-5
114214-69-6
General procedure for the synthesis of 1-Boc-3-hydroxymethylpyrrolidine from 3-pyrrolidine methanol and di-tert-butyl dicarbonate: 900 g of 3-pyrrolidine methanol was dissolved in 4.5 L of dichloromethane, and 900 g of di-tert-butyl dicarbonate and 1.8 kg of triethylamine were added in slow batch. The reaction mixture was stirred at room temperature for about 5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water. The product 1-Boc-3-hydroxymethylpyrrolidine was isolated and purified by conventional post-treatment methods in 95% yield.
References
[1] Patent: CN106588738, 2017, A. Location in patent: Paragraph 0035; 0037; 0040; 0045
[2] Synlett, 2017, vol. 28, # 4, p. 425 - 428
[3] Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 13, p. 1785 - 1789
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 21, p. 3235 - 3238
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 1151 - 1175
1-Boc-3-hydroxymethylpyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-3-hydroxymethylpyrrolidine Suppliers
- Tel
- --
- Fax
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- nfo@alkemi.be
- Country
- Belgium
- ProdList
- 2201
- Advantage
- 58
- Tel
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- sales@tcieurope.be
- Country
- Belgium
- ProdList
- 2200
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View Lastest Price from 1-Boc-3-hydroxymethylpyrrolidine manufacturers
- Product
- 1-Boc-3-hydroxymethylpyrrolidine 114214-69-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-06
- Product
- 1-Boc-3-hydroxymethylpyrrolidine 114214-69-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-25