N-ACETYL-5-HYDROXYTRYPTAMINE
- Product Name
- N-ACETYL-5-HYDROXYTRYPTAMINE
- CAS No.
- 1210-83-9
- Chemical Name
- N-ACETYL-5-HYDROXYTRYPTAMINE
- Synonyms
- Normelatoni;NORMELATONIN;AKOS BC-0717;N-Acetyl-5-HT;Acetylserotonin;N-ACETYLSEROTONIN;ACETYL-SEROTONINE;5-Hydroxymelatonin;O-Demethylmelatonin;MELATONINE EP IMP B
- CBNumber
- CB2737409
- Molecular Formula
- C12H14N2O2
- Formula Weight
- 218.25
- MOL File
- 1210-83-9.mol
N-ACETYL-5-HYDROXYTRYPTAMINE Property
- Melting point:
- 120-122 °C (lit.)
- Boiling point:
- 556.8±40.0 °C(Predicted)
- Density
- 1.268±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ethanol: 50 mg/mL
- form
- powder
- pka
- 10.09±0.40(Predicted)
- color
- white
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 1210-83-9(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A1824
- Product name
- N-Acetyl-5-hydroxytryptamine
- Purity
- ≥99% (TLC), powder
- Packaging
- 100mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- A1277
- Product name
- N-Acetyl-5-hydroxytryptamine
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $453
- Updated
- 2024/03/01
- Product number
- A1277
- Product name
- N-Acetyl-5-hydroxytryptamine
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 100mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 14535
- Product name
- N-Acetylserotonin
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 14535
- Product name
- N-Acetylserotonin
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $68
- Updated
- 2024/03/01
N-ACETYL-5-HYDROXYTRYPTAMINE Chemical Properties,Usage,Production
Chemical Properties
white to off-white or slightly pink powder
Uses
A metabolite of Melatonin (M215000).
Uses
N-Acetyl-5-hydroxytryptamine has been used to treat neuron cells and to analyze its effects on?Krüppel-like factor 15 (KLF15) expression.
Definition
ChEBI: A member of the class of hydroxyindoles that is the N-acetyl derivative of serotonin.
General Description
N-Acetylserotonin (NAS)/normelatonin acts as a precursor of melatonin in the tryptophan metabolic pathway.
Biological Activity
n-acetylserotonin is an agonist at the melatonin receptors mt1, mt2, and mt3.a melatonin receptor is a g protein-coupled receptor binding melatonin. three types of melatonin receptor have been identified. the mt1 and mt2 receptor subtypes are in humans and other mammals, whereas an additional melatonin receptor subtype mt3 has been identified in amphibia and birds.
Biochem/physiol Actions
N-acetyl-serotonin (NAS/normelatonin) can act as a shelter to neurons due to its protecting ability against oxidative challenges. It can also repress the actions of the transcription factor NF-kappaB. NAS possesses antioxidant and antiaging actions. It has protective action against β-amyloid induced neurotoxicity. It helps to maintain the optimal fluidity of the biological membranes.
in vitro
n-acetylserotonin, a precursor of melatonin, was acetylated from serotonin by arylalkylamine nacetyltransferase (aanat). n-acetylserotonin was found to be able to swiftly activate trkb in a circadian manner. n-acetylserotonin also exhibited antidepressant effect in a trkb-dependent manner. in additioin, n-acetylserotonin could rapidly activate trkb, but not trka or trkc, in a neurotrophin- and mt3 receptor-independent manner. moreover, n-acetylserotonin, but not melatonin, showed a robust antidepressant-like behavioral effect in a trkb-dependent way [1].
in vivo
animal study found that in bdnf knockout mice the administration of n-acetylserotonin could activate trkb. moreover, the endogenous trkb was activated in wild-type c3h/f+/+ mice but not in aanat-mutated c57bl/6j mice, in a circadian rhythm. in addition, trkb activation was found to be high at night in the dark and low during the day [1].
References
[1] jang, s. w.,liu, x.,pradoldej, s., et al. n-acetylserotonin activates trkb receptor in a circadian rhythm. proceedings of the national academy of sciences of the united states of america 107(8), 3876-3881 (2010).
N-ACETYL-5-HYDROXYTRYPTAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
N-ACETYL-5-HYDROXYTRYPTAMINE Suppliers
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- Germany
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- info@abcr.de
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- akos@akosgmbh.de
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- Germany
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- jaeger@biotrend.com
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- Germany
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View Lastest Price from N-ACETYL-5-HYDROXYTRYPTAMINE manufacturers
- Product
- N-ACETYL-5-HYDROXYTRYPTAMINE 1210-83-9
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Cusstomized
- Release date
- 2018-07-26