Agnuside

Product Name: Agnuside
CAS No.: 11027-63-7
Chemical Name: Agnuside
Synonyms: Agnusid;AGNUSIDE;Agnoside;Vitex Oil;Oyster oil;AGNUSIDE(P);Buddlejoside A;chasteberry oil;Agnuside (25 mg);AGNUSIDE WITH HPLC
CBNumber: CB2737818
Molecular Formula: C22H26O11
Formula Weight: 466.44
MOL File: 11027-63-7.mol

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Agnuside Property

Melting point:: 146℃
Boiling point:: 785.5±60.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO, Methanol
pka: 8.14±0.15(Predicted)
form: Solid
color: Yellow
optical activity: [α]/D -98.0±5°, c = 0.1 in ethanol
BRN: 4925795
InChI: InChI=1/C22H26O11/c23-8-15-17(26)18(27)19(28)22(32-15)33-21-16-11(7-14(25)13(16)5-6-30-21)9-31-20(29)10-1-3-12(24)4-2-10/h1-7,13-19,21-28H,8-9H2/t13-,14+,15-,16+,17-,18+,19-,21-,22+/s3
InChIKey: GLACGTLACKLUJX-QNAXTHAFSA-N
SMILES: [C@]12([H])C(COC(=O)C3=CC=C(O)C=C3)=C[C@H](O)[C@@]1([H])C=CO[C@@H]2O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O |&1:0,15,17,22,24,25,27,28,30,r|
LogP: -1.240 (est)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89155
Product name: Agnuside
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $441
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1012203
Product name: Agnuside
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1240
Updated: 2025/07/31

Sigma-Aldrich

Product number: 12274
Product name: Agnuside
Purity: analytical standard
Packaging: 10mg
Price: $511.8
Updated: 2024/03/01

Cayman Chemical

Product number: 24971
Product name: Agnuside
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 24971
Product name: Agnuside
Purity: ≥98%
Packaging: 5mg
Price: $156
Updated: 2024/03/01

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Agnuside Chemical Properties,Usage,Production

Chemical Properties

Yellow Oil

Uses

Agnuside is an known iridoid glycoside found in Vitex herbs or plants. Agnuside have been used in various applications including in the treatment of premenstrual syndrome and regulation of menopause s ymptoms. This is mainly due to the fact that Agnuside exhibits estrogen-like activities as it interacts with estrogen receptors (ER-alpha) and estrogen receptor-regulated pregesterone receptors. Recen t studies have also evaluated Agnuside for the probable mechanism of anti-arthritic activity, which suggested the possible development of Agnuside as a therapeutic agent in the treatment of arthritis by the modulation of the host immune response.

Definition

ChEBI: Agnuside is a benzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with the primary hydroxy group of aucubin. It is an iridoid glycoside found in several Vitex plants including Vitex agnus-castus. It has a role as a plant metabolite, an anti-inflammatory agent, a pro-angiogenic agent and a cyclooxygenase 2 inhibitor. It is a terpene glycoside, an iridoid monoterpenoid, a benzoate ester, a member of phenols, a beta-D-glucoside, a cyclopentapyran and a monosaccharide derivative. It is functionally related to an aucubin.

benefits

Agnuside is one of the most significant active ingredients in chasteberry and is described chemically as an ester of p-hydroxybenzoic acid and aucubin. Agnuside’s greatest areas of benefit involve female reproductive cycles, which researchers believe is due to its effect on the pituitary gland. One study has also shown that extracts of chasteberry fruit bind to the opiate receptors in the brain, which would explain its use in relieving discomfort.

in vivo

Agnuside (6.25 mg/kg; Oral administration; Single dose) reduces the levels of allergic inflammatory mediators in a dose-dependent manner and can inhibit allergic inflammation in Balb/C mice^[1]. Agnuside (6.25 mg/kg; Oral administration; Single dose) can inhibit autophagy in allergic asthma in Balb/C mice ^[1]. Agnuside (6.25 mg/kg; Oral administration; single dose) can reduce synovitis and fibrosis in knee osteoarthritis (KOA) in MIA-induced KOA mice^[4].

Animal Model:	Balb/C female mice model ^[1]
Dosage:	30 mg/kg, 60 mg/kg
Administration:	Oral gavage (p.o.); Single dose;
Result:	Decreased the expression of LC3B and increased the expression of Beclin1/p62 (LC3B and Beclin1/p62 are autophagy markers). Decreased the levels of IgE and IL-4/ IL-10 in a dose-dependent manner.( IgE and IL-4/ IL-10 are allergic inflammatory mediators)

Animal Model:	KAO rat model^[4]
Dosage:	6.25 mg Monosodium iodoacetate (MIA): 1 mg
Administration:	Oral gavage (p.o.); Single dose
Result:	Alleviated the degree of local hypoxia in the synovial tissue of rats and significantly reduced the level of pro-fibrotic substances in the synovial tissue. Inhibited the accumulation of HIF-1α and activation of NLRP3 inflammasome.

IC 50

EP

Agnuside Preparation Products And Raw materials

Raw materials

Preparation Products

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Agnuside Suppliers

Canada 2 China 207 France 2 Germany 4 India 1 Japan 1 United Kingdom 6 United States 19 USA 1 Global 243

Chengdu Biopurify Ltd.

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Email: cwb1@biopurify.cn
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ProdList: 3842
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Hubei Danding Pharmaceutical Technology Co., Ltd

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Country: China
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Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
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Country: China
ProdList: 11707
Advantage: 57

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
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Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
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Country: China
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View Lastest Price from Agnuside manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Agnuside 11027-63-7
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2022-09-30

Hebei Yanxi Chemical Co., Ltd.

Product: Agnuside 11027-63-7
Price: US $100.00-25.00/kgkg
Min. Order: 1kgkg
Purity: 0.99
Supply Ability: 100
Release date: 2023-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: Agnuside 11027-63-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

11027-63-7, AgnusideRelated Search:

Patchouli oil DL-Menthol Spearmint oil Carrot Seed Oil Cornmint oil Sandalwood oil Rhamnosylvitexin Vitexin CHLOROPHOSPHONAZO III 4-HYDROXYBENZOIC ACID ISOAMYL ESTER ACETALDEHYDE ETHYL CIS-3-HEXENYL ACETAL 3,4-DIHYDRO-2-METHOXY-4-METHYL-2H-PYRAN 4-HYDROXYBENZOIC ACID ALLYL ESTER (E)-2-METHYL-HEPTA-2,6-DIEN-1-OL Agnuside CHASTEBERRY 2-Ethoxy-3,4-dihydro-4-methyl-2H-pyran 4-(VINYLOXY)BUTYL BENZOATE 98

chasteberry oil

[(1r,2s,6s,7s)-7-hydroxy-2-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,8-dien-9-yl]methyl 4-hydroxybenzoate

AGNUSIDE

AGNUSIDE WITH HPLC

AGNUSIDE(P)

Agnuside (25 mg)

Vitex negundo oil，Agnuside

OLEUMVITICISNEGUNDO Oil

Vitex Oil

Agnoside

Buddlejoside A

(1S,4aR,5S,7aS)-1,4a,5,7a-Tetrahydro-5-hydroxy-7-[[(4-hydroxybenzoyl)oxy]methyl]cyclopenta[c]pyran-1-yl β-D-glucopyranoside

Agnusid

[(1S,4aR,5S,7aS)-5-hydroxy-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-7-yl]methyl 4-hydroxybenzoate

β-D-Glucopyranoside, (1S,4aR,5S,7aS)-1,4a,5,7a-tetrahydro-5-hydroxy-7-[[(4-hydroxybenzoyl)oxy]methyl]cyclopenta[c]pyran-1-yl

((1S,4aR,5S,7aS)-5-hydroxy-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-7-yl)methyl 4-hydroxybenzoate

Agnuside USP/EP/BP

Beta-Caryophyllene CAS 87-44-5

[(1R,4aS,5R,7aR)-5-hydroxy-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-7-yl]methyl 4-hydroxybenzoate

Agnuside chasteberry oil

AgnusideQ: What is Agnuside Q: What is the CAS Number of Agnuside Q: What is the storage condition of Agnuside Q: What are the applications of Agnuside

Oyster oil

Agnuside/OLEUM VITICIS NEGUNDO

(1S,4aR,5S,7aS)-5-hydroxy-1-[(2S,3R,4S,5S,6R)-3,

Agnuside, 10 mM in DMSO

11027-63-7

11027-65-7

C22H26O11

Aromatic Phenols