CHROMAN-4-YLAMINE
- Product Name
- CHROMAN-4-YLAMINE
- CAS No.
- 53981-38-7
- Chemical Name
- CHROMAN-4-YLAMINE
- Synonyms
- AKOS BB-9702;4-aminochroman;4-Chromanamine;4-Aminochromane;chroman-4-amine;AKOS BBS-00006847;CHROMAN-4-YLAMINE;3,4-DIHYDRO-2H-CHROMEN-4-AMINE;3,4-DIHYDRO-2H-CHROMEN-4-YLAMINE;3,4-dihydro-2H-1-benzopyran-4-aMine
- CBNumber
- CB2740599
- Molecular Formula
- C9H11NO
- Formula Weight
- 149.19
- MOL File
- 53981-38-7.mol
CHROMAN-4-YLAMINE Property
- Boiling point:
- 237.4±39.0 °C(Predicted)
- Density
- 1.106±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 8.87±0.20(Predicted)
- form
- liquid
- color
- Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C427985
- Product name
- Chroman-4-ylamine
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FC50898
- Product name
- Chroman-4-ylamine
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- OR931982
- Product name
- 3,4-Dihydro-2H-1-benzopyran-4-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $102
- Updated
- 2021/12/16
- Product number
- W6827
- Product name
- Chroman-4-amine
- Packaging
- 250mg
- Price
- $109
- Updated
- 2021/12/16
- Product number
- FC50898
- Product name
- Chroman-4-ylamine
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
CHROMAN-4-YLAMINE Chemical Properties,Usage,Production
Synthesis
491-37-2
53981-38-7
General procedure for the synthesis of benzodihydropyran-4-ylamine from 2,3-dihydrochromen-4-one: 2,3-dihydrochromen-4-one (3 g, 20.1 mmol), titanium(IV) isopropoxide (12.0 mL, 40.2 mmol), and an ethanol solution of 2 M ammonia (60.6 mL, 121.2 mmol) were mixed and stirred at room temperature for 6 hours. Subsequently, the reaction mixture was cooled to 0 °C and sodium borohydride (1.14 g, 30.2 mmol) was added in batches over 10 min. The resulting mixture was continued to be stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction was quenched by pouring the mixture into 2 M ammonium hydroxide solution (60 mL), the precipitate formed was filtered out and washed with ethyl acetate (15 mL x 3). The organic layer was separated and the remaining aqueous layer was further extracted with ethyl acetate (15 mL x 2). The organic extracts were combined and washed with 1 M HCl (25 mL). The acidic aqueous layer was washed with ethyl acetate (50 mL), adjusted to pH 10-12 with 2M aqueous sodium hydroxide and extracted with ethyl acetate (40 mL × 3). The organic extracts were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuum to give benzodihydropyran-4-ylamine as an oil (2.61 g, 87% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.31 (d, 1H), 7.23 (m, 1H), 6.94 (m, 1H), 6.82 (d, 1H), 4.38 (m, 2H), 4.12 (m, 1H), 2.19 (m, 2H), 1.82 (m, 2H).
References
[1] Patent: WO2006/81332, 2006, A1. Location in patent: Page/Page column 98
[2] Science, 2017, vol. 358, # 6361, p. 326 - 332
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981, vol. 20, # 12, p. 1063 - 1067
[4] Journal of Organic Chemistry, 2010, vol. 75, # 15, p. 5265 - 5270
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 5, p. 1338 - 1341
CHROMAN-4-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CHROMAN-4-YLAMINE manufacturers
- Product
- CHROMAN-4-YLAMINE 53981-38-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09