CHROMAN-6-CARBALDEHYDE
Uses- Product Name
- CHROMAN-6-CARBALDEHYDE
- CAS No.
- 55745-97-6
- Chemical Name
- CHROMAN-6-CARBALDEHYDE
- Synonyms
- 6-Chromanecarbaldehyde;CHROMAN-6-CARBALDEHYDE;Chroman-6-carboxaldehyde;Benzodihydropyran-6-carbaldehyde;3,4-Dihydro-2H-chromene-6-carboxaldehyde;3,4-dihydro-2H-1-benzopyran-6-carbaldehyde;2H-1-Benzopyran-6-carboxaldehyde, 3,4-dihydro-
- CBNumber
- CB7124956
- Molecular Formula
- C10H10O2
- Formula Weight
- 162.19
- MOL File
- Mol file
CHROMAN-6-CARBALDEHYDE Property
- Boiling point:
- 160-163 °C(Press: 20 Torr)
- Density
- 1.167±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Yellow to orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C384528
- Product name
- Chroman-6-carbaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2H15-1-20
- Product name
- Chroman-6-carboxaldehyde
- Packaging
- 250mg
- Price
- $136
- Updated
- 2021/12/16
- Product number
- Y9461
- Product name
- Chroman-6-carbaldehyde
- Packaging
- 100mg
- Price
- $178
- Updated
- 2021/12/16
- Product number
- 021026
- Product name
- Chroman-6-carbaldehyde
- Packaging
- 500mg
- Price
- $188
- Updated
- 2021/12/16
- Product number
- 021026
- Product name
- Chroman-6-carbaldehyde
- Packaging
- 1g
- Price
- $290
- Updated
- 2021/12/16
CHROMAN-6-CARBALDEHYDE Chemical Properties,Usage,Production
Uses
Benzodihydropyran-6-carboxaldehyde, also known as 6-aldehyde chromium, can be used as a useful intermediate for bioactive substances (such as vitamin E) and pharmaceutical reagents (such as diabetes treatment agents), or as a useful intermediate for polymer materials (such as engineering resins), and can also be used as a stabilizer for organic substances (such as fats and oils) and synthetic resins.
Synthesis
493-08-3
68-12-2
55745-97-6
To a mixed solution of 3,4-dihydro-1H-benzopyran (3 g, 22.4 mmol, 1.0 eq.) and N,N-dimethylformamide (3.3 g, 45.2 mmol, 2 eq.) in 1,2-dichloroethane (20 mL) was added phosphorus trichloride (3.4 g, 45.2 mmol, 2 eq.) dropwise, slowly at 50 °C or below, with dropwise addition time controlled at 30 minutes. The reaction mixture was then stirred continuously at 85 °C for 12 hours. Upon completion of the reaction, the reaction was quenched with ice water and extracted with ethyl acetate (3 x 300 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 8:1) to afford the yellow oily product benzodihydropyran-6-carbaldehyde (2.0 g, 12.3 mmol, 55.1% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz) and electrospray ionization mass spectrometry (ESIMS): 1H NMR δ 2.01 (q, J = 45.8 Hz, 2H), 2.82 (t, J = 6.4 Hz, 2H), 4.24 (t, J = 5.2 Hz, 2H), 6.85 (d, J = 8.4 Hz, 1H), 7.52- 7.64 (m, 2H), 9.79 (s, 1H); ESIMS m/z 163.1 ([M + H]+).
References
[1] Patent: US2014/243349, 2014, A1. Location in patent: Paragraph 1738; 1740
[2] Journal of the Indian Chemical Society, 1959, vol. 36, p. 76,80
CHROMAN-6-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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