Quipazine
- Product Name
- Quipazine
- CAS No.
- 4774-24-7
- Chemical Name
- Quipazine
- Synonyms
- QUIPAZINE;TIMTEC-BB SBB011283;1-(2-quinolyl)piperazine;2-(1-Piperazino)quinoline;2-PIPERAZIN-1-YL-QUINOLINE;2-(1-piperazinyl)quinoline;2-(1-piperazinyl)-quinolin;1-(2-quinolinyl)piperazine;Quinoline, 2-(1-piperazinyl)-;Quipazine ISO 9001：2015 REACH
- CBNumber
- CB2741602
- Molecular Formula
- C13H15N3
- Formula Weight
- 213.28
- MOL File
- 4774-24-7.mol
Quipazine Property
- Melting point:
- 81-83 °C
- Boiling point:
- 403.7±25.0 °C(Predicted)
- Density
- 1.152±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Solid
- pka
- 8.93±0.10(Predicted)
- color
- Off-white to light yellow
- CAS DataBase Reference
- 4774-24-7(CAS DataBase Reference)
Safety
- RTECS
- VC2513500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B450568
- Product name
- 2-(piperazin-1-yl)quinoline
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- API0006950
- Product name
- QUIPAZINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $175.35
- Updated
- 2021/12/16
- Product number
- 6520AB
- Product name
- 2-(Piperazin-1-yl)quinoline
- Packaging
- 1g
- Price
- $211
- Updated
- 2021/12/16
- Product number
- 138484
- Product name
- 2-Piperazin-1-yl-quinoline
- Purity
- 95%+
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 6520AB
- Product name
- 2-(Piperazin-1-yl)quinoline
- Packaging
- 250mg
- Price
- $117
- Updated
- 2021/12/16
Quipazine Chemical Properties,Usage,Production
Uses
antineoplastic
Definition
ChEBI: 2-(1-piperazinyl)quinoline is a member of pyridines and a member of piperazines.
Synthesis
110-85-0
612-62-4
4774-24-7
Step 1: Piperazine (10.20 g, 2.45 mmol) was dissolved in 15 mL of isopropanol in a dry round-bottomed flask under nitrogen protection. Subsequently, 2-chloroquinoline (0.20 g, 1.2 mmol) was added and the reaction mixture was heated and stirred at reflux for 24 hours. After completion of the reaction, water was added to the mixture and extracted with ethyl acetate. The organic layers were combined, washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by silica gel column chromatography with eluent ratio of dichloromethane:methanol=4:1 to afford the target compound 2-(piperazin-1-yl)quinoline in 36% yield.
in vivo
Quipazine (2.5, 5 and 7.5 mg/kg, one dose for once; i.p.) affects dietary self-selection of different macronutrient diets in male and female rats[1].
References
[1] Patent: EP1724267, 2006, A1. Location in patent: Page/Page column 35; 68
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 21, p. 7549 - 7563
[3] Journal of Pharmaceutical Sciences, 1992, vol. 81, # 1, p. 99 - 103
[4] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 10, p. 1314 - 1320
[5] Patent: WO2004/46124, 2004, A1. Location in patent: Page 41
Quipazine Preparation Products And Raw materials
Raw materials
Preparation Products
Quipazine Suppliers
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View Lastest Price from Quipazine manufacturers
- Product
- Quipazine 4774-24-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- Quipazine 4774-24-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-24
- Product
- Quipazine 4774-24-7
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-30