ChemicalBook > CAS DataBase List > Quipazine

Quipazine

Product Name
Quipazine
CAS No.
4774-24-7
Chemical Name
Quipazine
Synonyms
QUIPAZINE;TIMTEC-BB SBB011283;1-(2-quinolyl)piperazine;2-(1-Piperazino)quinoline;2-PIPERAZIN-1-YL-QUINOLINE;2-(1-piperazinyl)quinoline;2-(1-piperazinyl)-quinolin;1-(2-quinolinyl)piperazine;Quinoline, 2-(1-piperazinyl)-;Quipazine ISO 9001：2015 REACH
CBNumber
CB2741602
Molecular Formula
C13H15N3
Formula Weight
213.28
MOL File
4774-24-7.mol
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Quipazine Property

Melting point:
81-83 °C
Boiling point:
403.7±25.0 °C(Predicted)
Density 
1.152±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
Solid
pka
8.93±0.10(Predicted)
color 
Off-white to light yellow
CAS DataBase Reference
4774-24-7(CAS DataBase Reference)
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Safety

RTECS 
VC2513500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B450568
Product name
2-(piperazin-1-yl)quinoline
Packaging
1g
Price
$155
Updated
2021/12/16
AK Scientific
Product number
6520AB
Product name
2-(Piperazin-1-yl)quinoline
Packaging
250mg
Price
$117
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0006950
Product name
QUIPAZINE
Purity
95.00%
Packaging
250MG
Price
$175.35
Updated
2021/12/16
AK Scientific
Product number
6520AB
Product name
2-(Piperazin-1-yl)quinoline
Packaging
1g
Price
$211
Updated
2021/12/16
Matrix Scientific
Product number
138484
Product name
2-Piperazin-1-yl-quinoline
Purity
95%+
Packaging
1g
Price
$350
Updated
2021/12/16
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Quipazine Chemical Properties,Usage,Production

Uses

antineoplastic

Definition

ChEBI: 2-(1-piperazinyl)quinoline is a member of pyridines and a member of piperazines.

Synthesis

110-85-0

612-62-4

4774-24-7

Step 1: Piperazine (10.20 g, 2.45 mmol) was dissolved in 15 mL of isopropanol in a dry round-bottomed flask under nitrogen protection. Subsequently, 2-chloroquinoline (0.20 g, 1.2 mmol) was added and the reaction mixture was heated and stirred at reflux for 24 hours. After completion of the reaction, water was added to the mixture and extracted with ethyl acetate. The organic layers were combined, washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by silica gel column chromatography with eluent ratio of dichloromethane:methanol=4:1 to afford the target compound 2-(piperazin-1-yl)quinoline in 36% yield.

in vivo

Quipazine (2.5, 5 and 7.5 mg/kg, one dose for once; i.p.) affects dietary self-selection of different macronutrient diets in male and female rats[1].

References

[1] Patent: EP1724267, 2006, A1. Location in patent: Page/Page column 35; 68
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 21, p. 7549 - 7563
[3] Journal of Pharmaceutical Sciences, 1992, vol. 81, # 1, p. 99 - 103
[4] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 10, p. 1314 - 1320
[5] Patent: WO2004/46124, 2004, A1. Location in patent: Page 41

Quipazine Preparation Products And Raw materials

Raw materials

Preparation Products

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Quipazine Suppliers

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View Lastest Price from Quipazine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Quipazine 4774-24-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Dideu Industries Group Limited
Product
Quipazine 4774-24-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-24
Career Henan Chemical Co
Product
Quipazine 4774-24-7
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2019-12-30

4774-24-7, QuipazineRelated Search:

Quinhydrone N-Aminoethylpiperazine Isoquinoline Levodropropizine Quinclorac 2-Ethylhexyl ferulate Piperazine Quinoline Yellow Quinoline Piperacillin 4-METHYL-2-PIPERAZIN-1-YL-QUINOLINE QUIPAZINE, N-METHYL- DIMALEATE quipazine maleate,QUIPAZINE DIMALEATE SALT,QUIPAZINE MALEATE SALT,QUIPAZINE DIMALEATE 2-PIPERAZIN-1-YL-QUINOLINE-4-CARBOXYLIC ACID 4-(chloropropyl)-1-(2-quinolyl)piperazine QUIPAZINE, 6-NITRO-MALEATE (DU 24565) SE ROTONIN UPTAKE INHI Quipazine QUIPAZINE, 6-NITRO- MALEATE

  • 1-(2-quinolinyl)piperazine
  • 1-(2-quinolyl)piperazine
  • 2-(1-piperazinyl)-quinolin
  • 2-(1-piperazinyl)quinoline
  • QUIPAZINE DIMALEATE (2-(1-PIPERAZINYL)QU I
  • 2-(1-Piperazino)quinoline
  • 2-(piperazin-1-yl)quinoline hydrochloride
  • Quinoline, 2-(1-piperazinyl)-
  • QUIPAZINE
  • TIMTEC-BB SBB011283
  • 2-PIPERAZIN-1-YL-QUINOLINE
  • Quipazine ISO 9001：2015 REACH
  • 4774-24-7
  • pharmacetical
  • chem-chemical