ChemicalBook > CAS DataBase List > Citrazinic acid
Citrazinic acid
- Product Name
- Citrazinic acid
- CAS No.
- 99-11-6
- Chemical Name
- Citrazinic acid
- Synonyms
- 2,6-DIHYDROXYISONICOTINIC ACID;36470;2,6-DIHYDROXYPYRIDINE-4-CARBOXYLIC ACID;CGA-129218;Citrazinicaci;CITRAZANICACID;citrazinicacfd;AKOS NCG1-0104;itrazinic acid;Cltrazinic acid
- CBNumber
- CB2746425
- Molecular Formula
- C6H5NO4
- Formula Weight
- 155.11
- MOL File
- 99-11-6.mol
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Citrazinic acid Property
- Melting point:
- >300 °C(lit.)
- Boiling point:
- 278.88°C (rough estimate)
- Density
- 0.65 g/cm3
- refractive index
- 1.5423 (estimate)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- practically insoluble
- pka
- 2.54±0.20(Predicted)
- form
- Powder
- color
- Yellow
- PH
- 3.1-3.5 (100g/l, H2O)(slurry)
- Water Solubility
- practically insoluble
- Merck
- 14,2325
- BRN
- 383736
- InChIKey
- CSGQJHQYWJLPKY-UHFFFAOYSA-N
- CAS DataBase Reference
- 99-11-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Isonicotinic acid, 2,6-dihydroxy-,(99-11-6)
- EPA Substance Registry System
- Citrazinic acid (99-11-6)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-36/37/39-22
- WGK Germany
- 1
- RTECS
- NS1400000
- TSCA
- Yes
- HS Code
- 29333999
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 153281
- Product name
- 2,6-Dihydroxypyridine-4-carboxylic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $42.3
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 153281
- Product name
- 2,6-Dihydroxypyridine-4-carboxylic acid
- Purity
- 97%
- Packaging
- 100g
- Price
- $89.7
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C0571
- Product name
- Citrazinic Acid
- Purity
- >96.0%(T)
- Packaging
- 25g
- Price
- $67
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C0571
- Product name
- Citrazinic Acid
- Purity
- >96.0%(T)
- Packaging
- 500g
- Price
- $561
- Updated
- 2025/07/31
TRC
- Product number
- D453773
- Product name
- 2,6-DihydroxyisonicotinicAcid
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
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Citrazinic acid Chemical Properties,Usage,Production
Chemical Properties
yellow powder
Uses
2,6-Dihydroxypyridine-4-carboxylic acid was used to prepare 2,6-dibromo-4-(hexoxymethyl)pyridine. It was also used to synthesize the derivatives of oxazinones and pyrimidinones.
Uses
2,6-Dihydroxypyridine-4-carboxylic acid (citrazinic acid) was used to prepare 2,6-dibromo-4-(hexoxymethyl)pyridine. It was also used to synthesize the derivatives of oxazinones and pyrimidinones.
Definition
ChEBI: CITRAZINIC ACID is an aromatic carboxylic acid and a member of pyridines.
Synthesis
77-92-9
99-11-6
(1) Weigh 1.2188 g (0.0058 mol) of citric acid and 1.3932 g (0.0231 mol) of urea, dissolve in 60 ml of deionized water, and ultrasonicate for 10 min to ensure adequate mixing; (2) Transfer the mixed solution to a reaction vessel and place it in an oven preheated to 185 ℃, and maintain the reaction in hydrothermal conditions for 2 h; after completion of the reaction, cool naturally to After the reaction was completed, it was cooled naturally to room temperature to obtain a dark green solution; (3) the above solution was placed in a constant temperature water bath at 60 ℃, and 98% sulfuric acid was added dropwise slowly under magnetic stirring to adjust the pH of the solution to 2-3; at this time, a large number of yellow solids were precipitated, and the solution was centrifuged at 12,000 rpm for 10 minutes, the supernatant was discarded, and the precipitate was washed with deionized water for several times and drained; finally, the yellow precipitate was dried in the oven at 60 ℃, and citrazinic acid was obtained, with a yield of 85.18%. The yield was 85.18%.
Purification Methods
The acid is normally a yellow powder with a greenish shade, but is white when ultra pure and turns blue on long standing. It is insoluble in H2O but slightly soluble in hot HCl and soluble in alkali or carbonate solutions. It is purified by precipitation from alkaline solutions with dilute HCl, and dried in a vacuum over P2O5. The ethyl ester has m 232o (evacuated tube) and a pKa of 4.81 in MeOCH2CH2OH [IR: Pitha Coll Czech Chem Comm 28 1408 1963]. [Beilstein 22/7 V 24.]
References
[1] Patent: CN108164458, 2018, A. Location in patent: Paragraph 0010; 0012; 0013
[2] Journal of the American Pharmaceutical Association (1912-1977), 1956, vol. 45, p. 478
Citrazinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Citrazinic acid manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- Citrazinic acid 99-11-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-28
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
- Product
- Citrazinic Acid 99-11-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-11-15
Shaanxi Dideu Medichem Co. Ltd
- Product
- Citrazinic acid 99-11-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-08-25
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