ChemicalBook > CAS DataBase List > 4-Fluorophenylhydrazine hydrochloride
4-Fluorophenylhydrazine hydrochloride
- Product Name
- 4-Fluorophenylhydrazine hydrochloride
- CAS No.
- 823-85-8
- Chemical Name
- 4-Fluorophenylhydrazine hydrochloride
- Synonyms
- BIO-FARMA BF000369;4-Fluorophenylhydraz;4-Fluorophenylhydrazinehy;P-FluoroPhenylHydrazineHcl;4-FLUOROPHENYLHYDRAZINE HCL;4-FLUOROPHENYLHYDROZINE HCL;4-fluorophenazid hydrochloride;Fluorophenylhydrazine hydrochloride;4-FLUORPHENYL HYDRAZINE HYDROCHLORIDE;4-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE
- CBNumber
- CB2746728
- Molecular Formula
- C6H8ClFN2
- Formula Weight
- 162.59
- MOL File
- 823-85-8.mol
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4-Fluorophenylhydrazine hydrochloride Property
- Melting point:
- ≥300 °C(lit.)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Powder
- color
- White to brownish
- Water Solubility
- soluble
- BRN
- 3627721
- InChI
- InChI=1S/C6H7FN2.ClH/c7-5-1-3-6(9-8)4-2-5;/h1-4,9H,8H2;1H
- InChIKey
- FEKUXLUOKFSMRO-UHFFFAOYSA-N
- SMILES
- N(C1=CC=C(F)C=C1)N.[H]Cl
- CAS DataBase Reference
- 823-85-8(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-43-40-20/21/22
- Safety Statements
- 26-36-36/37/39-22
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29280090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H350May cause cancer
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- F14203
- Product name
- 4-Fluorophenylhydrazine hydrochloride
- Purity
- 97%
- Packaging
- 10g
- Price
- $77.7
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- F14203
- Product name
- 4-Fluorophenylhydrazine hydrochloride
- Purity
- 97%
- Packaging
- 50g
- Price
- $217
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0246
- Product name
- 4-Fluorophenylhydrazine Hydrochloride
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $42
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0246
- Product name
- 4-Fluorophenylhydrazine Hydrochloride
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $201
- Updated
- 2025/07/31
Usbiological
- Product number
- 276014
- Product name
- 4-Fluorophenylhydrazine HCl
- Packaging
- 100g
- Price
- $375
- Updated
- 2021/12/16
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4-Fluorophenylhydrazine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
light red powde
Uses
4-Fluorophenylhydrazine hydrochloride is used as a chemical intermediate in the pharmaceutica1ls particularly of tryptamine drugs used in the treatment of migraine and cluster headaches. It is used to prepare agrochemical, and other chemical. It is used to detect sugars and aldehydes in analytical chemistry.
Synthesis
371-40-4
823-85-8
The general procedure for the synthesis of 4-fluorophenylhydrazine hydrochloride from 4-fluoroaniline was as follows: 4-fluoroaniline (127.6 g, 1 mol) was dissolved in concentrated hydrochloric acid (293 mL) and stirred for 2 hours at room temperature. Subsequently, the above solution was slowly added dropwise to a solution of sodium nitrite (72.5 g, 1.05 mol) in water (145 mL) at a temperature controlled below 5 °C. After the dropwise addition, stirring was continued for 1 hour, and then the filtrate was separated by filtration to obtain the filtrate. A solution of NaHSO3 (213.2 g, 2.05 mol) in water (500 mL) was slowly added dropwise to the filtrate over a temperature range of 0-10 °C while the pH was adjusted with 25% NaOH solution to maintain between 6-7. The reaction mixture was heated to 80 °C and maintained at this temperature for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and then concentrated hydrochloric acid (600 mL) was added dropwise. Next, the mixture was heated to 90-100°C for 1 hour. Finally, the mixture was cooled to 10 °C and the precipitate was collected by filtration to give the light red solid product 4-fluorophenylhydrazine hydrochloride (129.3 g, 60% yield).
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 3149 - 3157
[2] Archiv der Pharmazie (Weinheim, Germany), 1994, vol. 327, # 2, p. 99 - 104
[3] Die Pharmazie, 1985, vol. 40, # 1, p. 21 - 22
[4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[5] Angewandte Chemie - International Edition, 2010, vol. 49, # 50, p. 9769 - 9772
4-Fluorophenylhydrazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluorophenylhydrazine hydrochloride manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- Hydrazine, (p-fluorophenyl)-, hydrochloride 823-85-8
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-09-08
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 4-Fluorophenylhydrazine hydrochloride 823-85-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-22
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 4-Fluorophenylhydrazine hydrochloride 823-85-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
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