tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate

Product Name: tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate
CAS No.: 214834-18-1
Chemical Name: tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate
Synonyms: BUTTPARK 146\06-96;1-Boc-4-thiocarbamoylpiperidine;N-Boc-4-PiperidinecarbothioaMide;N-BOC-piperidine-4-carbothioamide;1-Boc-piperidine-4-carbothioamide;N-BOC-Piperidine-4-thiocarboxamide;N1-BOC-PIPERIDINE-4-THIOCARBOXAMIDE;4-Carbamothioylpiperidine, N1-BOC protected;PIPERIDINE-4-THIOCARBOXAMIDE, 1-BOC PROTECTED;Piperidine-4-thiocarboxamide, N1-BOC protected
CBNumber: CB2748762
Molecular Formula: C11H20N2O2S
Formula Weight: 244.35
MOL File: 214834-18-1.mol

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tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate Property

Melting point:: 130 °C
Boiling point:: 356.0±52.0 °C(Predicted)
Density: 1.158±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
pka: 13.03±0.20(Predicted)
color: White

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Safety

Hazard Codes: Xi,Xn,N
Risk Statements: 20/21/22-36/37/38-22-50
Safety Statements: 26-36/37/39-22-61
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Apolloscientific

Product number: OR8046
Product name: 4-Carbamothioylpiperidine,N1-BOCprotected
Purity: 95%
Packaging: 1g
Price: $18
Updated: 2021/12/16

AK Scientific

Product number: X4353
Product name: 1-Boc-4-Thiocarbamoylpiperidine
Packaging: 1g
Price: $25
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB53494
Product name: 1-N-Boc-piperidine-4-thiocarboxamide
Packaging: 1g
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR8046
Product name: 4-Carbamothioylpiperidine,N1-BOCprotected
Purity: 95%
Packaging: 5g
Price: $76
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB53494
Product name: 1-N-Boc-piperidine-4-thiocarboxamide
Packaging: 2g
Price: $85
Updated: 2021/12/16

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tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate Chemical Properties,Usage,Production

Synthesis

91419-48-6

214834-18-1

General procedure for the synthesis of tert-butyl 4-aminothiocarbonyltetrahydropyridine-1(2H)-carboxylate from tert-butyl 4-carbamoylpiperidine-1-carboxylate: tert-butyl 4-carbamoylpiperidine-1-carboxylate (2.65 g, 11.62 mmol) was dissolved in a solvent mixture of DME/DCM (2:1, 78 mL), followed by addition of Lawesson reagent (2.35 g, 5.81 mmol, 0.5 equiv). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate and washed with saturated aqueous K2CO3 solution. The organic layer was separated, dried with anhydrous Na2SO4, filtered and concentrated to dryness. The obtained residue was ground with ether and dried to give tert-butyl 4-aminothiocarbonyltetrahydropyridine-1(2H)-carboxylate (2.65 g, 92% yield) as a white solid. The product was analyzed by HPLC showing a retention time (Rt) of 5.06 min. 1H NMR (401 MHz, DMSO-d6) δ ppm: 9.39 (br.s., 1H), 9.09 (br.s., 1H), 4.00 (d, J=12.6 Hz, 2H), 2.77-2.61 (m, 3H), 1.71-1.51 (m , 4H), 1.39 (br.s., 9H).

References

[1] Patent: WO2012/113774, 2012, A1. Location in patent: Page/Page column 40
[2] Patent: US2013/324551, 2013, A1. Location in patent: Paragraph 0311; 0312; 0313
[3] Patent: WO2011/153435, 2011, A1. Location in patent: Page/Page column 13-14
[4] Patent: US2011/318418, 2011, A1. Location in patent: Page/Page column 12
[5] Patent: WO2016/30443, 2016, A1. Location in patent: Page/Page column 102

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate Suppliers

Belgium 1 China 103 Germany 3 India 3 United Kingdom 4 United States 12 Global 126

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View Lastest Price from tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: tert-Butyl 4-carbamothioylpiperidine-1-carboxylate 214834-18-1
Price: US $3.90-5.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-13

Career Henan Chemical Co

Product: tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate 214834-18-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

214834-18-1, tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylateRelated Search:

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BUTTPARK 146\06-96

PIPERIDINE-4-THIOCARBOXAMIDE, 1-BOC PROTECTED

TERT-BUTYL 4-(AMINOCARBOTHIOYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE

Piperidine-4-thiocarboxamide, N1-BOC protected

Piperidine-4-thiocarboxamide, N1-BOC protected 97%

N1-BOC-PIPERIDINE-4-THIOCARBOXAMIDE

1-tert-Butoxycarbonylpiperidine-4-carbothioamide

tert-butyl 4-(aminocarbothioyl)tetrahydropyridine-

tert-butyl 4-thiocarbamoylpiperidine-1-carboxylate

N-BOC-piperidine-4-carbothioamide

tert-butyl 4-(aminocarbonothioyl)piperidine-1-carboxylate

N-Boc-4-PiperidinecarbothioaMide

4-Carbamothioylpiperidine, N1-BOC protected 97%

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-carbamothioylpiperidine, 1-(tert-Butoxycarbonyl)piperidine-4-thiocarboxamide

1-Piperidinecarboxylicacid,4-(aMinothioxoMethyl)-,1,1-diMethylethylester

tert-Butyl 4-(aMinocarbothioyl)-tetrahydropyridin-1(2H)--carboxylate

4-(4-phenylthiazol-2-yl)piperidine-1-carboxylic acid tert-butyl ester

1-Boc-4-thiocarbamoylpiperidine

N-BOC-Piperidine-4-thiocarboxamide

4-(4-phenylthiazol-2-yl)piperidine-1-carboxylic acid tert-butyl

1-Boc-piperidine-4-carbothioamide

tert-butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carb...

4-Carbamothioylpiperidine, N1-BOC protected

214834-18-1

C11H20N2O2S

Pyrans, Piperidines &Piperazines

Pyrans, Piperidines & Piperazines