ChemicalBook > CAS DataBase List > KN-93

KN-93

Product Name
KN-93
CAS No.
139298-40-1
Chemical Name
KN-93
Synonyms
KN-93;KN KN;CS-1099;KN-93,98%;KN-93-H3PO4;KN-93(free base);KN-93;KN 93;KN93;KN 93 (Z/E form);InSolution? KN-93;KN-93 base or HCI
CBNumber
CB2751988
Molecular Formula
C26H29ClN2O4S
Formula Weight
501.04
MOL File
139298-40-1.mol
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KN-93 Property

Density 
1.288
storage temp. 
2-8°C
solubility 
DMSO: 1 mg/mL
form 
Off-white solid
color 
white
InChIKey
LLLQTDSSHZREGW-AATRIKPKSA-N
CAS DataBase Reference
139298-40-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
22-24/25-36/37
WGK Germany 
3
HS Code 
29299000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
K1385
Product name
KN-93
Purity
≥98% (HPLC)
Packaging
0.1mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
K1385
Product name
KN-93
Purity
≥98% (HPLC)
Packaging
0.5mg
Price
$388
Updated
2024/03/01
Sigma-Aldrich
Product number
422708
Product name
KN-93
Packaging
1mg
Price
$181
Updated
2023/06/20
Sigma-Aldrich
Product number
422708
Product name
KN-93
Packaging
5mg
Price
$586
Updated
2023/06/20
TCI Chemical
Product number
K0055
Product name
KN-93
Purity
>98.0%(HPLC)
Packaging
5mg
Price
$135
Updated
2024/03/01
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KN-93 Chemical Properties,Usage,Production

Description

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cells.

Chemical Properties

white to off-white powder

Uses

KN-93 has been used:

  • as an inhibitor to block αCaMKII (Ca2+/calmodulin-dependent protein kinase IIα)
  • as CaMKII inhibitor to pre-treat hippocampal slices
  • to treat the cells, to alter the cytoskeleton (CSK) structure and function during the experiment

Uses

A potent and selective inhibitor of Ca2+/Calmoduline-dependent protein kinase II (CaMKII).

Definition

ChEBI: A sulfonamide resulting from the formal condensation of p-methoxybenzenesulfonic acid with the anilino nitrogen of 2-(aminomethyl)-N-(2-hydroxyethyl)aniline in which the hydrogens of the primary amino group have been replace by methyl and p-chlorocinnamyl groups. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II.

General Description

Cell-permeable, reversible, and competitive inhibitor of rat brain Ca+2/calmodulin-dependent protein kinase II (Ki = 370 nM). KN-93 selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.

Biological Activity

Potent inhibitor of CaM kinase II (IC 50 = 0.37 μ M). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC 50 = 307 nM for Kv1.5); independent of CaM kinase II inhibition.

Biochem/physiol Actions

KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50 ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step.

storage

Store at +4°C

KN-93 Preparation Products And Raw materials

Raw materials

Preparation Products

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KN-93 Suppliers

Americas 1 Belgium 1 Canada 1 China 104 Europe 1 Germany 3 India 5 Japan 3 South Korea 1 Switzerland 2 United Kingdom 6 United States 28 Global 156
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
MOLEKULA Ltd.
Tel
--
Fax
--
Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
Fluorochem Ltd
Tel
--
Fax
--
Email
vernam@fluorochem.co.uk
Country
United Kingdom
ProdList
6375
Advantage
65
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
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View Lastest Price from KN-93 manufacturers

Career Henan Chemica Co
Product
KN-93 139298-40-1
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98%HPLC/LC
Supply Ability
g/kg/tons
Release date
2020-11-02

139298-40-1, KN-93Related Search:

N-Methylaniline 2-Methylaminoethanol N-Methyl pyrrole N-Methylbenzamide N-Methyldiethanolamine KN-93 in Solution KN-93 P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE 4-HYDROXY-N-PHENYLBENZENE SULPHONAMIDE

  • 2-[N-(2-HYDROXYETHYL)-N-(4-METHOXYBENZENESULFONYL)]AMINO-N-(4-CHLOROCINNAMYL)-N-METHYLBENZYLAMINE
  • METHOXYBENZENE-SULFONAMIDE
  • KN-93
  • KN-93, WATER-SOLUBLE
  • N-[2-[[[3-(4'-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4'-METHOXY-BENZENESULFONAMIDE PHOSPHATE
  • N-[2-[[[3-(4-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4-METHOXYBENZENESULPHONAMIDE
  • N-[2-N-4-CHLOROCINNAMYL-N-METHYLAMINOMETHYLPHENYL]-N-[2-HYDROXYETHYL]-4-METHOXYBENZENESULFONAMIDE
  • KN-93,98%
  • KN-932-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
  • N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate salt
  • N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
  • n-[2-[[[3-(4'-chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-n-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide phosphate salt
  • N-[2-[[[3-(4-Chlorophenyl)-2-propen-1-yl]MethylaMino]Methyl]phenyl]-N-(2-hydroxyethyl)-4-MethoxybenzenesulfonaMide
  • KN-93(free base)
  • KN-93 - CAS 139298-40-1 - Calbiochem
  • InSolution KN-93 - CAS 139298-40-1 - Calbiochem
  • CS-1099
  • N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4-METHOXYBENZENESULFONAMIDE
  • KN-93;KN 93;KN93
  • KN-93-H3PO4
  • KN 93 N-[2-[[[3-(4-Chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
  • N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxyb
  • InSolution? KN-93
  • KN-93 base or HCI
  • KN KN
  • N-?[2-?({[(2E)?-?3-?(4-?CHLOROPHENYL)?PROP-?2-?EN-?1-?YL]?(METHYL)?AMINO}?METHYL)?PHENYL]?-?2-?HYDROXY-?S-?(4-?METHOXYPHENYL)?ETHANESULFONAMIDO
  • Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-
  • N-[2-[[[3-(4-Chlorophenyl)allyl](methyl)amino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
  • Inhibitor,Calmodulin-dependent protein kinases,Autophagy,KN-93,KN 93,KN93,Calmodulin-dependent kinases,inhibit,CaMK
  • KN 93 (Z/E form)
  • 139298-40-1
  • C26H29ClN2O4S
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Inhibitors
  • Cell Signaling and Neuroscience
  • Calcium/Calmodulin-Dependent Protein Kinase (CaMK)
  • Cell Biology
  • BioChemical
  • Inhibitors
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Protein Kinase