PHALLOIDIN-TRITC LABELED Property

Flash point:

11 °C

storage temp. 

−20°C

form 

solid

biological source

sequence from Amanita phalloides (synthetic: peptide sequence)

Safety

Hazard Codes 

T+,T,F

Risk Statements 

26/27/28-39/23/24/25-23/24/25-11

Safety Statements 

36/37/39-45-36/37-28-22-16

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

PHALLOIDIN-TRITC LABELED Chemical Properties,Usage,Production

Uses

Fluorescent phallotoxin which may be used to identify filamentous actin.
Phalloidin-Tetramethylrhodamine B isothiocyanate has been used:-

• In Immunofluorescence for staining Filamentous actin (F-actin)
• To stain cells during immunocytochemical and cytochemical analysis
• To label actin microfilaments for fluorescence microscopy

Biological Activity

Phalloidin interacts with polymeric actin, and not oligomeric or monomeric forms. This interaction leads to highly stabilized actin filaments, which resist depolymerization and disassembly. In rats, this toxin causes death due to liver hemorrhage, and cells show abnormal actin clustering. The affinity of phalloidin to actin is not significantly altered after derivatizing florescent labelled phalloidin compounds. These compounds can be used to study actin structure and organization within eukaryotic cells.', 'Toxin th at binds polymeric F actin, stabilizing it and interfering with the function of actin-rich structures.