Description Structure Sources
ChemicalBook > CAS DataBase List > 2-Chloro-5-(chloromethyl)pyridine

2-Chloro-5-(chloromethyl)pyridine

Description Structure Sources
Product Name
2-Chloro-5-(chloromethyl)pyridine
CAS No.
70258-18-3
Chemical Name
2-Chloro-5-(chloromethyl)pyridine
Synonyms
2-chloro-chloromethylpyridine;Pyridine, 2-chloro-5-(chloromethyl)-;6-Chlo;60% in DMF;AKOS MSC-0759;AURORA KA-6694;2-Chloro-5-(ch;TIMTEC-BB SBB003948;2-Chloro-5-Chloro-Me;imidacloprid impurity
CBNumber
CB2761158
Molecular Formula
C6H5Cl2N
Formula Weight
162.02
MOL File
70258-18-3.mol
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2-Chloro-5-(chloromethyl)pyridine Property

Melting point:
37-42 °C(lit.)
Boiling point:
267.08°C (rough estimate)
Density 
1.4411 (rough estimate)
refractive index 
1.6000 (estimate)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
-0.75±0.10(Predicted)
form 
Moist Crystals
color 
Beige
Water Solubility 
Insoluble in water.
BRN 
1635690
InChI
InChI=1S/C6H5Cl2N/c7-3-5-1-2-6(8)9-4-5/h1-2,4H,3H2
InChIKey
SKCNYHLTRZIINA-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(CCl)C=C1
CAS DataBase Reference
70258-18-3(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi,F
Risk Statements 
22-34-36-10
Safety Statements 
26-36/37/39-45-25-36-16
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive/Harmful
HazardClass 
LACHRYMATOR, CORROSIVE
HazardClass 
8
PackingGroup 
II
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
516910
Product name
2-Chloro-5-(chloromethyl)pyridine
Purity
97%
Packaging
5g
Price
$49.1
Updated
2024/03/01
Sigma-Aldrich
Product number
516910
Product name
2-Chloro-5-(chloromethyl)pyridine
Purity
97%
Packaging
25g
Price
$59.04
Updated
2024/03/01
TCI Chemical
Product number
C1628
Product name
2-Chloro-5-(chloromethyl)pyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$156
Updated
2024/03/01
TCI Chemical
Product number
C1628
Product name
2-Chloro-5-(chloromethyl)pyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$460
Updated
2024/03/01
Alfa Aesar
Product number
L19284
Product name
2-Chloro-5-(chloromethyl)pyridine, 96%
Packaging
5g
Price
$41.65
Updated
2024/03/01
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2-Chloro-5-(chloromethyl)pyridine Chemical Properties,Usage,Production

Description

2-Chloro-5-chloromethylpyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds1, having insecticidal activity. It is the raw material of pesticide products such as imidacloprid, acetamiprid as well as bactericide and herbicide2,3.

Structure

2-Chloro-5-(chloromethyl)pyridine, C6H5Cl2N, is almost planar, with an r.m.s. deviation of 0.0146 Å for all atoms except for the 5-choloromethyl Cl atom. The offset Cl atom lies above this plane with a Cl—C—C angle of 111.11 (17)°. In the crystal, mol­ecules are connected via inter­molecular C—H⋯N hydrogen bonds, forming dimers. The crystals were obtained by dissolving 2-Chloro-5-(chloromethyl)pyridine (0.2 g, 1.2 mmol) in ethanol (25 ml) and evaporating the solvent slowly at room temperature for about 5 d[1].

Sources

  1. https://www.alfa.com/en/catalog/L19284/
  2. https://www.trc-canada.com/product-detail/?C364715
  3. www.szqhbio.com/wap_news_detailen/id/1.htm

Chemical Properties

beige moist crystals

Uses

2-Chloro-5-(chloromethyl)pyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds.

References

[1] Zhi-Qiang Feng. “2-Chloro-5-(chloro-meth-yl)pyridine.” Acta crystallographica. Section E, Structure reports online 67 Pt 2 (2011): o366.

2-Chloro-5-(chloromethyl)pyridine Preparation Products And Raw materials

Raw materials

Nicotinic acid 3-(Chloromethyl)pyridine 2-Chloro-5-trichloromethylpyridine Phosphorus pentoxide 2-Chloro-5-methylpyridine 1,3-Cyclopentadiene

Preparation Products

Acetamiprid
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View Lastest Price from 2-Chloro-5-(chloromethyl)pyridine manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
2-Chloro-5-chloromethylpyridine 70258-18-3
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-16
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Chloro-5-chloromethylpyridine 70258-18-3
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-04-24
Jinan Finer Chemical Co., Ltd
Product
2-Chloro-5-chloromethylpyridine 70258-18-3
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000mt/year
Release date
2022-09-28

70258-18-3, 2-Chloro-5-(chloromethyl)pyridineRelated Search:

2-Chloro-5-trichloromethylpyridine 2-(Chloromethyl)pyridine 2,6-Lutidine Chromium picolinate Pyridine Clopidol Azamethiphos 2,4,6-Collidine 4-Methylpyridine 2-Chloro-5-methylpyridine 2,6-DICHLORO-5-FLUORONICOTINOYL CHLORIDE 2,6-DICHLORO-3-(CHLOROMETHYL)PYRIDINE 2,3-Dichloro-5-(trichloromethyl)pyridine Difluorochloromethane 6-CHLORONICOTINOYL CHLORIDE 2,6-dichloro-3-(trichloromethyl)pyridine 2-CHLORO-5-(CHLOROMETHYL)PYRIDINE HYDROCHLORIDE 2,4-DICHLORO-5-(CHLOROMETHYL)-PYRIDINE

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  • AKOS MSC-0759
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  • Fampridine Impurity 215
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  • 70258-18-3
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  • BENZYL HALIDE
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyridines
  • Chloropyridines
  • Halopyridines
  • Building Blocks
  • Pharmaceutical intermediates
  • C6Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • Chloropyridines
  • Halopyridines
  • Methyl Halides
  • Heterocycle-Pyridine series
  • API Intermediate
  • Pyridine series
  • Methyl Halides
  • HALOMETYL
  • Pyridine
  • 70258-18-3