1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine
- Product Name
- 1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine
- CAS No.
- 34161-24-5
- Chemical Name
- 1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine
- Synonyms
- FIPEXIDE;1-[(p-Chlorophenoxy)acetyl]-4-piperonylpiperazine;1-(4-Chlorophenoxyacetyl)-4-(1,3-benzodioxole-5-ylmethyl)piperazine;1-(2-[4-chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine;1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-chlorophenoxy)ethanone;Ethanone, 1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)-;senile,dementia,Adenylate Cyclase,Fipexide,dopaminergic,acid,SLC6A3,parachloro-phenossiacetic,performance,nootropic,inhibit,Dopamine Transporter,Inhibitor,cognitive,Adenylyl cyclase,neurotransmission,DAT
- CBNumber
- CB2762544
- Molecular Formula
- C20H21ClN2O4
- Formula Weight
- 388.84
- MOL File
- 34161-24-5.mol
1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine Property
- Boiling point:
- 559.3±50.0 °C(Predicted)
- Density
- 1.342±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 33 mg/mL (84.87 mM)
- pka
- 6.29±0.10(Predicted)
- CAS DataBase Reference
- 34161-24-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Fipexide(34161-24-5)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- F6270
- Product name
- Fipexide hydrochloride
- Purity
- analytical standard
- Packaging
- 5g
- Price
- $54.7
- Updated
- 2022/05/15
- Product number
- F342223
- Product name
- Fipexide
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-4721
- Product name
- Fipexide
- Purity
- 99.99%
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- API0010009
- Product name
- FIPEXIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $902.29
- Updated
- 2021/12/16
1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine Chemical Properties,Usage,Production
Originator
Attentil,Ravizza
Uses
psychostimulant
Uses
Fipexide is one of five potential drug candidates to overcome the melphalan-induced vascular toxicity.
Definition
ChEBI: 1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone is a member of benzodioxoles.
Manufacturing Process
25.8 g (0.3 moles) of anhydrous piperazine and 32.5 ml (1.8 moles) of
distilled water (or simply 58.3 g (0.3 moles) of piperazine hexahydrate) are
loaded into a 250 ml flask provided with an agitator, a thermometer and a
reflux condenser, together with 51.2 g (0.3 moles) of piperonyl chloride,
whereupon 2 g of cetyltrimethylammonium bromide are added to the mixture
with vigorous agitation, and the flask is cooled with water so that the
temperature of the reaction mass under agitation does not rise above 110°C.
Once the exothermic stage is exhausted, the temperature is maintained at
130°C by an external oil bath, for 90 min under agitation.
After cooling, a solid mass is obtained which is taken up with 400 ml of an
aqueous solution containing 10% by weight of caustic soda to dissolve the
product from the mass. The alkaline solution thus obtained is extracted twice
with 500 ml of chloroform. The extract is washed with water and then
evaporated to dryness. The residue is crystallised from 96% ethanol.
50.5 g (theoretical value 53.18 g) of 1,4-bispiperonylpiperazine as a paleyellowish
white crystals are obtained with a melting point of 155-156°C; the
hydrochloride melts with decomposition above 260°C.
Preparation of fipexidum hydrochloride:
106.3 g (0.3 moles) of 1,4-bispiperonylpiperazine are dissolved in 750 ml of
hot benzene in a 2,000 ml flask provided with a stirrer and a reflux condenser
and 38 g (0.45 moles) of dry, powdered sodium bicarbonate are added. After
cooling to ambient temperature, 92.3 g (0.45 moles, corresponding to 63 ml)
of the chloride of p-chlorophenoxyacetic acid are added slowly, with agitation,
and the mixture is heated under reflux for 7 hours. The benzene is then
almost totally recovered by distillation at atmospheric pressure and the
residue is evaporated to dryness under vacuum. The solid residue thus
obtained is taken up with 400 ml of aqueous solution at 10% sodium
hydroxide (1 mole) and the alkaline liquid phase is extracted twice with 600
ml of chloroform. The chloroform extracts are joined together and washed
with a little water and then agitated vigorously with a solution of 200 ml of
concentrated hydrochloric acid in 300 ml of water. An abundant white
precipitate is obtained. After filtration under vacuum, the precipitate is treated
with boiling ethanol; the 1-((p-chlorophenoxy)acetyl)-4-piperonylpiperazine
hydrochloride (fipexide hydrochloride) passes into solution while the
dihydrochloride of hydrochloric acid remains undissolved and is separated by
filtration while hot. The alcoholic filtrate is cooled, with consequent slow
crystallization of the fipexide hydrochloride. 70.2 g of the product are obtainedwith a yield of 55%; melting point is (in Kofler) 228-230°C.
brand name
Attenil 30 conf. 20 mg;Fipexitum;Fipexium;Vigilor 200 mg cpr msfp.
Therapeutic Function
Antidepressant, Psychostimulant
World Health Organization (WHO)
Fipexide, a stimulant of the central nervous system, was introduced in 1973 for the treatment of depression and memory defects. Following its association with hepatic and hemopoietic disorders, particularly in children, the drug was withdrawn in France. Although not widely marketed, it may still remain registered elsewhere.
1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine Suppliers
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7815
- Advantage
- 57
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9664
- Advantage
- 60
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- 0086-571-86217390
- Fax
- 0086-571-86217391
- Sales@gihichem.com
- Country
- China
- ProdList
- 861
- Advantage
- 58
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3421
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29797
- Advantage
- 68
- Tel
- 13761635123
- Fax
- 1014988033@qq
- 1014988033@qq.com
- Country
- China
- ProdList
- 4979
- Advantage
- 55
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4880
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3238
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30255
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49391
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
- Country
- China
- ProdList
- 24734
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4196
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44941
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 9946
- Advantage
- 58
- Tel
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29778
- Advantage
- 58
- Tel
- 0757-85921206 18520245316
- 2329783215@qq.com
- Country
- China
- ProdList
- 12664
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24131
- Advantage
- 58
- Tel
- 029-63373950 15353716720
- 1052@dideu.com
- Country
- China
- ProdList
- 10011
- Advantage
- 58
- Tel
- 0512-65118909 15162312715
- sales@szzxbio.com
- Country
- China
- ProdList
- 2999
- Advantage
- 58
- Tel
- 18122215013
- 780229652@qq.com
- Country
- China
- ProdList
- 939
- Advantage
- 58
- Tel
- 021-59167510 18117107507
- vip@med-life.cn
- Country
- China
- ProdList
- 5019
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12007
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48518
- Advantage
- 58
- Tel
- 13298105281 13298105281
- 1522334715@qq.com
- Country
- China
- ProdList
- 7496
- Advantage
- 58
- Tel
- 18024082417
- sales@ubiochem.com
- Country
- China
- ProdList
- 9146
- Advantage
- 58
- Tel
- 008657128800458; +8615858145714
- Fax
- +86-571-56059825
- fandachem@gmail.com
- Country
- China
- ProdList
- 9341
- Advantage
- 55
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 32686
- Advantage
- 60
- Tel
- +86-89586680 +86-13289823923
- 1026@dideu.com
- Country
- China
- ProdList
- 9020
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6921
- Advantage
- 58
- Tel
- --
- Fax
- --
- WHIGA22@126.COM
- Country
- CHINA
- ProdList
- 6748
- Advantage
- 58
- Tel
- --
- Fax
- --
- jingkehuaxue@163.com
- Country
- CHINA
- ProdList
- 6974
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6846
- Advantage
- 58
- Tel
- --
- Fax
- --
- 570202610@qq.com
- Country
- CHINA
- ProdList
- 6851
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@shrbio.com
- Country
- CHINA
- ProdList
- 6873
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@etrustin.com
- Country
- China
- ProdList
- 5364
- Advantage
- 51
- Tel
- --
- Fax
- --
- weibochem@163.com
- Country
- China
- ProdList
- 6187
- Advantage
- 67
View Lastest Price from 1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine manufacturers
- Product
- 1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine 34161-24-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26