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Bisantrene

Product Name
Bisantrene
CAS No.
78186-34-2
Chemical Name
Bisantrene
Synonyms
ADAH;CS-2227;Zantrene;CL-216942;BISANTRENE;NSC-337766;Orange Crush;BISANTRENE HCL;Bisantrene, >96%;Bisantrene USP/EP/BP
CBNumber
CB2764144
Molecular Formula
C22H22N8
Formula Weight
398.46
MOL File
78186-34-2.mol
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Bisantrene Property

Boiling point:
646.3±65.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
deionized water: soluble8mg/mL
form 
solid
pka
9.78±0.10(Predicted)
color 
Orange to red
InChIKey
NJSMWLQOCQIOPE-OCHFTUDZSA-N
SMILES
C1(/C=N/NC2=NCCN2)=C2C=CC=CC2=C(/C=N/NC2=NCCN2)C2C=CC=CC1=2
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
60-61
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B4563
Product name
Bisantrene dihydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$86.9
Updated
2024/03/01
Sigma-Aldrich
Product number
B4563
Product name
Bisantrene dihydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$138
Updated
2024/03/01
ChemScene
Product number
CS-6132
Product name
Bisantrene
Purity
95.44%
Packaging
25mg
Price
$144
Updated
2021/12/16
ChemScene
Product number
CS-6132
Product name
Bisantrene
Purity
95.44%
Packaging
50mg
Price
$240
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008652
Product name
BISANTRENE
Purity
95.00%
Packaging
10MG
Price
$605.17
Updated
2021/12/16
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Bisantrene Chemical Properties,Usage,Production

Originator

Bisantrene hydrochloride,ZYF Pharm Chemical

Uses

Antineoplastic.

Definition

ChEBI: A hydrazone resulting from the formal condensation of both of the aldehyde groups of anthracene-9,10-dicarbaldehyde with 2-hydrazinyl-4,5-dihydro-1H-imidazole.

Manufacturing Process

A 33.0 g (0.135 mole) of 2-methylthio-2-imidazoline hydroiodide is dissolved in 300 ml of water and treated with 8 ml (0.16 mole) of hydrazine hydrate. The mixture is stirred at room temperature for 20 hours and then taken to dryness under reduced pressure. The residue is dissolved in 250 ml of water and again taken to dryness under reduced pressure. The residue is redissolved in 250 ml of water and added to a mixture of 250 ml of water, 25 ml of concentrated hydrochloric acid and 25 g of silver oxide. The resulting mixture is stirred on a steam bath for 4 hours and then filtered. The filtrate is reduced to dryness under reduced pressure. The residue is dissolved in 300 ml of ethanol and 20 ml of water at the boil, clarified and cooled at -10°C. The precipitate is collected, washed with ethanol and ether and dried at 60°C and then 110°C under reduced pressure. Yield of the 2-hydrazino-2- imidazoline hydrochloride 11.6 g, melting point 177-180°C.
The 2-hydrazino-2-imidazoline monohydrochloride is converted to the dihydrochloride by treatment with ethanol and concentrated hydrochloric acid. A suspension of 3.46 g of the 2-hydrazino-2-imidazoline dihydrochloride and 2.34 g of 9,10-anthracenedicarboxaldehyde in 100 ml of ethanol is stirred and heated under reflux for two hours. The mixture is cooled and the solid is collected and washed with ethanol giving the desired product as a crystalline orange solid, m.p. 288-289°C (dec.).

Therapeutic Function

Antineoplastic

Bisantrene Preparation Products And Raw materials

Raw materials

Preparation Products

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Bisantrene Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
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View Lastest Price from Bisantrene manufacturers

Career Henan Chemica Co
Product
Bisantrene 78186-34-2
Price
US $1.00/KG
Min. Order
1KG
Purity
MIn98%HPLC/LC
Supply Ability
100KGS
Release date
2020-10-29
Dideu Industries Group Limited
Product
Bisantrene 78186-34-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-02
Shaanxi Dideu Medichem Co. Ltd
Product
Bisantrene 78186-34-2
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

78186-34-2, BisantreneRelated Search:


  • BISANTRENE
  • BISANTRENE HCL
  • 9,10-An-thracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-y1)hydrazone]
  • 9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone)
  • 9,10-Bis((2-(4,5-dihydro-1H-iMidazol-2-yl)hydrazono)Methyl)anthracene
  • Bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone)-9,10-anthracenedicarboxaldehyde dihydrochloride
  • ADAH
  • CL-216942
  • NSC-337766
  • Orange Crush
  • Zantrene
  • 9,10-Anthracenedicarbaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]
  • Bisantrene, >96%
  • CS-2227
  • Bisantrene dihydrochloride >=98% (HPLC)
  • Bisantrene USP/EP/BP
  • inhibit,CL-216942,Topoisomerase,CL 216942,Bisantrene,Inhibitor
  • 9,10-Anthracenedicarboxaldehyde, 9,10-bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]
  • 2-{2-[(10-{[2-(4,5-dihydro-1H-imidazol-2-yl)hydrazin-1-ylidene]methyl}anthracen-9-yl)methylidene]hydrazin-1-yl}-4,5-dihydro-1H-imidazole
  • 78186-34-2
  • C22H22N8