Bisantrene

ChemicalBook > CAS DataBase List > Bisantrene

Product Name: Bisantrene
CAS No.: 78186-34-2
Chemical Name: Bisantrene
Synonyms: ADAH;CS-2227;Zantrene;CL-216942;BISANTRENE;NSC-337766;Orange Crush;BISANTRENE HCL;Bisantrene, >96%;Bisantrene USP/EP/BP
CBNumber: CB2764144
Molecular Formula: C22H22N8
Formula Weight: 398.46
MOL File: 78186-34-2.mol

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Bisantrene Property

Boiling point:: 646.3±65.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: deionized water: soluble8mg/mL
form: solid
pka: 9.78±0.10(Predicted)
color: Orange to red
InChIKey: NJSMWLQOCQIOPE-OCHFTUDZSA-N
SMILES: C1(/C=N/NC2=NCCN2)=C2C=CC=CC2=C(/C=N/NC2=NCCN2)C2C=CC=CC1=2

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50/53
Safety Statements: 60-61
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B4563
Product name: Bisantrene dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $86.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: B4563
Product name: Bisantrene dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $138
Updated: 2024/03/01

ChemScene

Product number: CS-6132
Product name: Bisantrene
Purity: 95.44%
Packaging: 25mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-6132
Product name: Bisantrene
Purity: 95.44%
Packaging: 50mg
Price: $240
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008652
Product name: BISANTRENE
Purity: 95.00%
Packaging: 10MG
Price: $605.17
Updated: 2021/12/16

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Bisantrene Chemical Properties,Usage,Production

Originator

Bisantrene hydrochloride,ZYF Pharm Chemical

Uses

Antineoplastic.

Definition

ChEBI: A hydrazone resulting from the formal condensation of both of the aldehyde groups of anthracene-9,10-dicarbaldehyde with 2-hydrazinyl-4,5-dihydro-1H-imidazole.

Manufacturing Process

A 33.0 g (0.135 mole) of 2-methylthio-2-imidazoline hydroiodide is dissolved in 300 ml of water and treated with 8 ml (0.16 mole) of hydrazine hydrate. The mixture is stirred at room temperature for 20 hours and then taken to dryness under reduced pressure. The residue is dissolved in 250 ml of water and again taken to dryness under reduced pressure. The residue is redissolved in 250 ml of water and added to a mixture of 250 ml of water, 25 ml of concentrated hydrochloric acid and 25 g of silver oxide. The resulting mixture is stirred on a steam bath for 4 hours and then filtered. The filtrate is reduced to dryness under reduced pressure. The residue is dissolved in 300 ml of ethanol and 20 ml of water at the boil, clarified and cooled at -10°C. The precipitate is collected, washed with ethanol and ether and dried at 60°C and then 110°C under reduced pressure. Yield of the 2-hydrazino-2- imidazoline hydrochloride 11.6 g, melting point 177-180°C.
The 2-hydrazino-2-imidazoline monohydrochloride is converted to the dihydrochloride by treatment with ethanol and concentrated hydrochloric acid. A suspension of 3.46 g of the 2-hydrazino-2-imidazoline dihydrochloride and 2.34 g of 9,10-anthracenedicarboxaldehyde in 100 ml of ethanol is stirred and heated under reflux for two hours. The mixture is cooled and the solid is collected and washed with ethanol giving the desired product as a crystalline orange solid, m.p. 288-289°C (dec.).

Therapeutic Function

Antineoplastic

Bisantrene Preparation Products And Raw materials

Raw materials

Bisantrene 4,5-dihydro-1H-imidazole

Preparation Products

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View Lastest Price from Bisantrene manufacturers

Career Henan Chemica Co

Product: Bisantrene 78186-34-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: MIn98%HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-29

Dideu Industries Group Limited

Product: Bisantrene 78186-34-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-02

Shaanxi Dideu Medichem Co. Ltd

Product: Bisantrene 78186-34-2
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

78186-34-2, BisantreneRelated Search:

Methimazole Levamisole hydrochloride Mebendazole Levamisole Mizolastine 9-ANTHRALDEHYDE HYDRAZONE 9,10-DIMETHYLANTHRACENE Bisantrene hydrochloride,Bisantrene dihydrochloride Midazolam 9,10-ANTHRACENEDICARBOXALDEHYDE Bisantrene orange grush bisantrene-tetrachloroplatinum dianion complex Bisantrene

BISANTRENE

BISANTRENE HCL

9，10-An-thracenedicarboxaldehyde bis[(4，5-dihydro-1H-imidazol-2-y1)hydrazone]

9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone)

9,10-Bis((2-(4,5-dihydro-1H-iMidazol-2-yl)hydrazono)Methyl)anthracene

Bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone)-9,10-anthracenedicarboxaldehyde dihydrochloride

ADAH

CL-216942

NSC-337766

Orange Crush

Zantrene

9,10-Anthracenedicarbaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]

Bisantrene, >96%

CS-2227

Bisantrene dihydrochloride >=98% (HPLC)

Bisantrene USP/EP/BP

inhibit,CL-216942,Topoisomerase,CL 216942,Bisantrene,Inhibitor

9,10-Anthracenedicarboxaldehyde, 9,10-bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]

2-{2-[(10-{[2-(4,5-dihydro-1H-imidazol-2-yl)hydrazin-1-ylidene]methyl}anthracen-9-yl)methylidene]hydrazin-1-yl}-4,5-dihydro-1H-imidazole

78186-34-2

C22H22N8