PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALT

Product Name: PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALT
CAS No.: 23197-96-8
Chemical Name: PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALT
Synonyms: PuTP;PUTP SODIUM SALT;Purine riboside triphosphate;Purine riboside-5'-triphosphate;PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALT;purineriboside-5’-o-triphosphate(putp),sodiumsalt;1-purin-9-yl-O5-(tetrahydroxy-[1]triphosphoryl)-β-D-1-deoxy-ribofuranose
CBNumber: CB2770826
Molecular Formula: C10H11N4Na4O13P3
Formula Weight: 580.09
MOL File: 23197-96-8.mol

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Hazard and Precautionary Statements (GHS)

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PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALT Chemical Properties,Usage,Production

Uses

Purine riboside-5'-O-triphosphate, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 μM and 28 μM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate also inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 μM[1][2][3].

References

[1] Kozlowska M, et al. ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside. Toxicol Lett. 1999;104(3):171-181. DOI:10.1016/s0378-4274(98)00369-5
[2] Moore CL, et al. Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates. Biochemistry. 2004;43(38):12367-12374. DOI:10.1021/bi0490791
[3] Kwiatkowski AP, et al. Mapping of the adenosine 5'-triphosphate binding site of type II calmodulin-dependent protein kinase. Biochemistry. 1987;26(24):7636-7640. DOI:10.1021/bi00398a016

PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALT Suppliers

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23197-96-8, PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALTRelated Search:

guanosine 5'-(tetrasodium triphosphate) Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) ADENOSINE 5'-TRIPHOSPHATE, TETRASODIUM SALT, [8-14C]- BETA-BROMOADENOSINE-5'-TRIPHOSPHATE SODIUM 8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT 2'-(N-METHYLANTHRANILOYL)ADENOSINE TRIPHOSPHATE, SODIUM SALT 2-METHYLTHIOADENOSINE TRIPHOSPHATE TETRASODIUM ADENOSINE 5'-TRIPHOSPHATE, TETRASODIUM SALT, [2,8-3H] PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALT

PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALT

PUTP SODIUM SALT

purineriboside-5’-o-triphosphate(putp),sodiumsalt

1-purin-9-yl-O5-(tetrahydroxy-[1]triphosphoryl)-β-D-1-deoxy-ribofuranose

PuTP

Purine riboside triphosphate

Purine riboside-5'-triphosphate

23197-96-8