8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT

Product Name: 8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT
CAS No.: 185341-71-3
Chemical Name: 8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT
Synonyms: 8-Cl-ATP;8-CL-ATP SODIUM SALT;8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT;8-chloroadenosine-5’-triphosphate(8-cl-atp),sodiumsalt;({[({[(2R,3S,4R,5R)-5-(6-amino-8-chloro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonicacid
CBNumber: CB1216419
Molecular Formula: C10H11ClN5Na4O13P3
Formula Weight: 629.55
MOL File: 185341-71-3.mol

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Hazard and Precautionary Statements (GHS)

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8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT Chemical Properties,Usage,Production

Uses

8-Chloro-ATP, an ATP (HY-B2176) analog, is a topoisomerase II (Topo II) inhibitor. 8-Chloro-ATP inhibits DNA synthesis and induces DNA double-stranded breaks (DSBs). 8-Chloro-ATP inhibits Topo II-catalyzed ATP hydrolysis[1].

IC 50

Topoisomerase II

References

[1] Sheng-Yong Yang, et al. Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells. Biochem Pharmacol. 2009 Feb 1;77(3):433-43. DOI:10.1016/j.bcp.2008.10.022

8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT Preparation Products And Raw materials

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Preparation Products

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8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT Suppliers

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185341-71-3, 8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALTRelated Search:

L-Methionine,2'-ester with 3'-deoxyadenosine PURINE RIBOSIDE-5'-O-TRIPHOSPHATE SODIUM SALT 8-CHLOROADENINE 2'-DEOXYADENOSINE-5'-TRIPHOSPHATE DISODIUM SALT 8-CHLORO-2'-DEOXYADENOSINE Adenosinehydrochloride 8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT 2-CHLORO-1-ETHOXYMETHYLIMIDAZOLE 8-Chloroadenosine Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI)

8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT

8-CL-ATP SODIUM SALT

8-chloroadenosine-5’-triphosphate(8-cl-atp),sodiumsalt

8-Cl-ATP

({[({[(2R,3S,4R,5R)-5-(6-amino-8-chloro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonicacid

185341-71-3