8-Chloroadenosine

Product Name: 8-Chloroadenosine
CAS No.: 34408-14-5
Chemical Name: 8-Chloroadenosine
Synonyms: 8-Cl-rA;8-CL-ADO;NSC354258;NSC-354258;NSC 354258;8-CHLOROADENOSINE;ADENOSINE, 8-CHLORO;8-Chloro-D-adenosine;8-CHLOROADENOSINE USP/EP/BP;6-Amino-8-chloropurine riboside
CBNumber: CB5219382
Molecular Formula: C10H12ClN5O4
Formula Weight: 301.69
MOL File: 34408-14-5.mol

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8-Chloroadenosine Property

Melting point:: 189-191 °C
Boiling point:: 707.4±70.0 °C(Predicted)
Density: 2.19±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
pka: 12.90±0.70(Predicted)
form: Crystalline solid.
color: White to off-white
InChI: InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
InChIKey: MHDPPLULTMGBSI-UUOKFMHZSA-N
SMILES: OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2Cl)[C@H](O)[C@@H]1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 4436
Product name: 8-Chloroadenosine
Purity: ≥98%(HPLC)
Packaging: 10
Price: $219
Updated: 2021/12/16

Tocris

Product number: 4436
Product name: 8-Chloroadenosine
Purity: ≥98%(HPLC)
Packaging: 50
Price: $915
Updated: 2021/12/16

Usbiological

Product number: 295571
Product name: 8-Chloroadenosine
Packaging: 1mg
Price: $375
Updated: 2021/12/16

Usbiological

Product number: 254457
Product name: 8-Chloroadenosine
Packaging: 10mg
Price: $480
Updated: 2021/12/16

TRC

Product number: C364113
Product name: 8-Chloroadenosine
Packaging: 5mg
Price: $70
Updated: 2021/12/16

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8-Chloroadenosine Chemical Properties,Usage,Production

Description

8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Uses

8-Chloroadenosine (cas# 34408-14-5) is a useful research chemical.8-Chloroadenosine is an analog of adenosine which depletes ATP and inhibits tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.

Biological Activity

8-Chloroadenosine (8-Cl-Ado), an adenosine analog, is a potential antitumor drug that is currently in phase-I clinical trials for chronic lymphocytic leukemia (CLL). It has been reported that 8-Cl-Ado inhibits cancer cell growth and induces apoptosis in Granta, JeKo, Mino, and SP-53 MCL cell lines by inhibition of both DNA and RNA syntheses. In addition, 8-Cl-Ado induces autophagy in primary CLL cells5 and in MCF-7 and BT-474 breast cancer cells6. Research has shown that 8-Cl-Ado inhibits the proliferation and migration of SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells by targeting the RNA-editing enzyme ADAR1[1].

storage

Store at -20°C

References

[1] Hong-Yue Ding. “8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway.” Cell Transplantation (2020): 963689720958656.

8-Chloroadenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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8-Chloroadenosine Suppliers

China 80 Germany 2 India 2 Switzerland 1 United Kingdom 3 United States 10 Global 98

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
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Advantage: 58

Zhengzhou GranLen pharmaceutical Technology Co., Ltd.

Tel: 0371-85513397
Email: info@granlen.com
Country: China
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Shanghai Kewel Chemical Co., Ltd.

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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Email: yftan@aikonchem.com
Country: China
ProdList: 16679
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EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

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View Lastest Price from 8-Chloroadenosine manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 8-Chloroadenosine 34408-14-5
Price: US $15.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000Kg
Release date: 2021-11-26

Career Henan Chemical Co

Product: 8-CHLOROADENOSINE 34408-14-5
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-02-21

34408-14-5, 8-Chloroadenosine Related Search:

2-Chloroadenosine 8-Chloroadenosine 2'-Deoxy-2-chloroadenosine 2-CHLOROADENOSINE HEMIHYDRATE,2-CHLOROADENOSINE HEMIDYDRATE 6-Deamino-6-chloroadenosine 2-Amino-6-chloropurine Riboside 8-CHLOROADENOSINE-5'-O-MONOPHOSPHATE SODIUM SALT,8-chloroadenosine-5’-monophosphate(8-cl-5’-amp),freeaci 8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT,8-chloroadenosine-5’-triphosphate(8-cl-atp),sodiumsal 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 8-CHLORO-CAMP N-Cyclopentyl-2-chloroadenosine 2-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT,2-chloroadenosine-3’,5’-cyclicmonophosphate,sodiumsalt(2-cl-camp 2-Chloroadenosine 5’-Monophosphate 2-CHLOROADENOSINE, [8-14C]- 5'-Deoxy-5'-chloroadenosine (+)-5'-O-[[(S)-2-Amino-1-oxopropyl]aminosulfonyl]-2-chloroadenosine DIINOSINE PENTAPHOSPHATE

8-Chloro-D-adenosine

8-Cl-rA

8-CL-ADO

8-CHLOROADENOSINE

ADENOSINE, 8-CHLORO

6-Amino-8-chloropurine riboside

2-(6-amino-8-chloro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol

8-CHLOROADENOSINE USP/EP/BP

NSC 354258

NSC354258

NSC-354258

8-Chloroadenosine, neoplastic and autoimmune agent anticancer agent

2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

8Chloroadenosine,8 Chloroadenosine

8-Chloroadenosine, 10 mM in DMSO

(2R,3R,4S,5R)-2-(6-Amino-8-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

34408-14-5

34408-14-6