8-Chloroadenosine
- Product Name
- 8-Chloroadenosine
- CAS No.
- 34408-14-5
- Chemical Name
- 8-Chloroadenosine
- Synonyms
- 8-Cl-rA;8-CL-ADO;NSC354258;NSC-354258;NSC 354258;8-CHLOROADENOSINE;ADENOSINE, 8-CHLORO;8-Chloro-D-adenosine;8-CHLOROADENOSINE USP/EP/BP;6-Amino-8-chloropurine riboside
- CBNumber
- CB5219382
- Molecular Formula
- C10H12ClN5O4
- Formula Weight
- 301.69
- MOL File
- 34408-14-5.mol
8-Chloroadenosine Property
- Melting point:
- 189-191 °C
- Boiling point:
- 707.4±70.0 °C(Predicted)
- Density
- 2.19±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
- pka
- 12.90±0.70(Predicted)
- form
- Crystalline solid.
- InChI
- InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
- InChIKey
- MHDPPLULTMGBSI-UUOKFMHZSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2Cl)[C@H](O)[C@@H]1O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4436
- Product name
- 8-Chloroadenosine
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $219
- Updated
- 2021/12/16
- Product number
- 4436
- Product name
- 8-Chloroadenosine
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $915
- Updated
- 2021/12/16
- Product number
- 295571
- Product name
- 8-Chloroadenosine
- Packaging
- 1mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- 254457
- Product name
- 8-Chloroadenosine
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- C364113
- Product name
- 8-Chloroadenosine
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
8-Chloroadenosine Chemical Properties,Usage,Production
Description
8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.
Uses
8-Chloroadenosine (cas# 34408-14-5) is a useful research chemical.8-Chloroadenosine is an analog of adenosine which depletes ATP and inhibits tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.
Biological Activity
8-Chloroadenosine (8-Cl-Ado), an adenosine analog, is a potential antitumor drug that is currently in phase-I clinical trials for chronic lymphocytic leukemia (CLL). It has been reported that 8-Cl-Ado inhibits cancer cell growth and induces apoptosis in Granta, JeKo, Mino, and SP-53 MCL cell lines by inhibition of both DNA and RNA syntheses. In addition, 8-Cl-Ado induces autophagy in primary CLL cells5 and in MCF-7 and BT-474 breast cancer cells6. Research has shown that 8-Cl-Ado inhibits the proliferation and migration of SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells by targeting the RNA-editing enzyme ADAR1[1].
storage
Store at -20°C
References
[1] Hong-Yue Ding. “8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway.” Cell Transplantation (2020): 963689720958656.
8-Chloroadenosine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-Chloroadenosine manufacturers
- Product
- 8-Chloroadenosine 34408-14-5
- Price
- US $15.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000Kg
- Release date
- 2021-11-26
- Product
- 8-CHLOROADENOSINE 34408-14-5
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-02-21