ChemicalBook > CAS DataBase List > 8-Chloroadenosine

8-Chloroadenosine

Product Name
8-Chloroadenosine
CAS No.
34408-14-5
Chemical Name
8-Chloroadenosine
Synonyms
8-Cl-rA;8-CL-ADO;NSC354258;NSC-354258;NSC 354258;8-CHLOROADENOSINE;ADENOSINE, 8-CHLORO;8-Chloro-D-adenosine;8-CHLOROADENOSINE USP/EP/BP;6-Amino-8-chloropurine riboside
CBNumber
CB5219382
Molecular Formula
C10H12ClN5O4
Formula Weight
301.69
MOL File
34408-14-5.mol
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8-Chloroadenosine Property

Melting point:
189-191 °C
Boiling point:
707.4±70.0 °C(Predicted)
Density 
2.19±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
pka
12.90±0.70(Predicted)
form 
Crystalline solid.
color 
White to off-white
InChI
InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
InChIKey
MHDPPLULTMGBSI-UUOKFMHZSA-N
SMILES
OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2Cl)[C@H](O)[C@@H]1O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
4436
Product name
8-Chloroadenosine
Purity
≥98%(HPLC)
Packaging
10
Price
$219
Updated
2021/12/16
Tocris
Product number
4436
Product name
8-Chloroadenosine
Purity
≥98%(HPLC)
Packaging
50
Price
$915
Updated
2021/12/16
TRC
Product number
C364113
Product name
8-Chloroadenosine
Packaging
5mg
Price
$70
Updated
2021/12/16
TRC
Product number
C364113
Product name
8-Chloroadenosine
Packaging
10mg
Price
$105
Updated
2021/12/16
Usbiological
Product number
295571
Product name
8-Chloroadenosine
Packaging
1mg
Price
$375
Updated
2021/12/16
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8-Chloroadenosine Chemical Properties,Usage,Production

Description

8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Uses

8-Chloroadenosine (cas# 34408-14-5) is a useful research chemical.8-Chloroadenosine is an analog of adenosine which depletes ATP and inhibits tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.

Biological Activity

8-Chloroadenosine (8-Cl-Ado), an adenosine analog, is a potential antitumor drug that is currently in phase-I clinical trials for chronic lymphocytic leukemia (CLL). It has been reported that 8-Cl-Ado inhibits cancer cell growth and induces apoptosis in Granta, JeKo, Mino, and SP-53 MCL cell lines by inhibition of both DNA and RNA syntheses. In addition, 8-Cl-Ado induces autophagy in primary CLL cells5 and in MCF-7 and BT-474 breast cancer cells6. Research has shown that 8-Cl-Ado inhibits the proliferation and migration of SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells by targeting the RNA-editing enzyme ADAR1[1].

storage

Store at -20°C

References

[1] Hong-Yue Ding. “8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway.” Cell Transplantation (2020): 963689720958656.

8-Chloroadenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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8-Chloroadenosine Suppliers

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View Lastest Price from 8-Chloroadenosine manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
8-Chloroadenosine 34408-14-5
Price
US $15.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
1000Kg
Release date
2021-11-26
Career Henan Chemical Co
Product
8-CHLOROADENOSINE 34408-14-5
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-02-21

34408-14-5, 8-Chloroadenosine Related Search:

2-Chloroadenosine 8-Chloroadenosine 2'-Deoxy-2-chloroadenosine 2-CHLOROADENOSINE HEMIHYDRATE,2-CHLOROADENOSINE HEMIDYDRATE 6-Deamino-6-chloroadenosine 2-Amino-6-chloropurine Riboside 8-CHLOROADENOSINE-5'-O-MONOPHOSPHATE SODIUM SALT,8-chloroadenosine-5’-monophosphate(8-cl-5’-amp),freeaci 8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT,8-chloroadenosine-5’-triphosphate(8-cl-atp),sodiumsal 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 8-CHLORO-CAMP N-Cyclopentyl-2-chloroadenosine 2-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT,2-chloroadenosine-3’,5’-cyclicmonophosphate,sodiumsalt(2-cl-camp 2-Chloroadenosine 5’-Monophosphate 2-CHLOROADENOSINE, [8-14C]- 5'-Deoxy-5'-chloroadenosine (+)-5'-O-[[(S)-2-Amino-1-oxopropyl]aminosulfonyl]-2-chloroadenosine DIINOSINE PENTAPHOSPHATE

  • 8-Chloro-D-adenosine
  • 8-Cl-rA
  • 8-CL-ADO
  • 8-CHLOROADENOSINE
  • ADENOSINE, 8-CHLORO
  • 6-Amino-8-chloropurine riboside
  • 2-(6-amino-8-chloro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 8-CHLOROADENOSINE USP/EP/BP
  • NSC 354258
  • NSC354258
  • NSC-354258
  • 8-Chloroadenosine, neoplastic and autoimmune agent anticancer agent
  • 2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 8Chloroadenosine,8 Chloroadenosine
  • 8-Chloroadenosine, 10 mM in DMSO
  • (2R,3R,4S,5R)-2-(6-Amino-8-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • 34408-14-5
  • 34408-14-6