8-CHLOROADENINE
- Product Name
- 8-CHLOROADENINE
- CAS No.
- 28128-28-1
- Chemical Name
- 8-CHLOROADENINE
- Synonyms
- 8-CL-ADE;8-CHLOROADENINE;8-Chloro-7H-purin-6-aMine;8-chloro-9H-purin-6-aMine;9H-Purin-6-amine, 8-chloro-
- CBNumber
- CB7757273
- Molecular Formula
- C5H4ClN5
- Formula Weight
- 169.57
- MOL File
- 28128-28-1.mol
8-CHLOROADENINE Property
- Boiling point:
- 269.0±50.0 °C(Predicted)
- Density
- 2.09±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 6.40±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- 267505
- Product name
- 8-Chloroadenine
- Packaging
- 1mg
- Price
- $476
- Updated
- 2021/12/16
- Product number
- NUC0003085
- Product name
- 8-CHLOROADENINE
- Purity
- 97.00%
- Packaging
- 5MG
- Price
- $498.03
- Updated
- 2021/12/16
- Product number
- FC09245
- Product name
- 8-Chloroadenine
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- FC09245
- Product name
- 8-Chloroadenine
- Packaging
- 1mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 2736AB
- Product name
- 8-Chloro-7H-purin-6-amine
- Packaging
- 100mg
- Price
- $226
- Updated
- 2021/12/16
8-CHLOROADENINE Chemical Properties,Usage,Production
Synthesis
58-61-7
28128-28-1
Example 1 Synthesis of 8-chloroadenine (1) To a solution of DMA/HCl (0.5 M, 45 mL) of adenosine (2.67 g, 10 mmol) was added m-chloroperoxybenzoic acid (MCPBA, 3.22 g, 16 mmol, 87%) at room temperature and the reaction was carried out for 2.5 hours. Subsequently, MCPBA (0.9 g, 5 mmol) was added additionally and stirring was continued for 1 hour. Upon completion of the reaction, toluene (50 mL) was added and evaporated to dryness at 60 °C under vacuum. The residue was dissolved in water (50 mL) and extracted with ether (3 x 50 mL). The aqueous phase was adjusted to pH 5 with 2N NaOH and diluted with EtOH (100 mL). The solution was placed in a refrigerator overnight. The precipitated yellowish solid was collected by filtration, washed with cold EtOH (2 x 25 mL) and dried to give a product of 1.44 g (85.2% yield). The product was characterized as follows: melting point 305-310 °C (decomposition); IR (KBr) showed 630 cm?1 (C-Cl) and 3100-3300 cm?1 (NH?) absorption peaks; UV spectra at pH 1 with λmax=262 nm (ε=8700), pH 7 with λmax=268 nm (ε=7900), and pH 11 with λmax= 269 nm (ε=8300); 1H NMR (Me?SO-d?) chemical shift δ 7.48 (broad peak, 2H, NH?), 8.10 (single peak, 1H, C?-H), 13.60 (broad peak, 1H, N?-H).
References
[1] Patent: US4861873, 1989, A
8-CHLOROADENINE Preparation Products And Raw materials
Raw materials
Preparation Products
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