ChemicalBook > CAS DataBase List > 4-(1H-Imidazol-1-yl)aniline

4-(1H-Imidazol-1-yl)aniline

Product Name: 4-(1H-Imidazol-1-yl)aniline
CAS No.: 2221-00-3
Chemical Name: 4-(1H-Imidazol-1-yl)aniline
Synonyms: LANA-IN-1;AKOS B021935;AKOS BB-8983;AKOS BBS-00000369;ART-CHEM-BB B021935;4-imidazolyl-aniline;4-(1-imidazolyl)aniline;4-(IMIDAZOL-1-YL)-ANILINE;1-(4-AMINOPHENYL)IMIDAZOLE;4-(1H-IMIDAZOL-1-YL)ANILINE
CBNumber: CB2771878
Molecular Formula: C9H9N3
Formula Weight: 159.19
MOL File: 2221-00-3.mol

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4-(1H-Imidazol-1-yl)aniline Property

Melting point:: 143-147 °C(lit.)
Boiling point:: 355.4±25.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder
pka: 6.05±0.10(Predicted)
CAS DataBase Reference: 2221-00-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29332900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 444391
Product name: 4-(1H-Imidazol-1-yl)aniline
Purity: 98%
Packaging: 1g
Price: $66.53
Updated: 2025/07/31

Sigma-Aldrich

Product number: 444391
Product name: 4-(1H-Imidazol-1-yl)aniline
Purity: 98%
Packaging: 5g
Price: $369
Updated: 2025/07/31

TCI Chemical

Product number: I1288
Product name: 4-(1H-Imidazol-1-yl)aniline
Packaging: 1G
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: I1288
Product name: 4-(1H-Imidazol-1-yl)aniline
Packaging: 5G
Price: $120
Updated: 2025/07/31

TRC

Product number: I577318
Product name: 4-(1H-Imidazol-1-yl)aniline
Packaging: 1g
Price: $75
Updated: 2021/12/16

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4-(1H-Imidazol-1-yl)aniline Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

LANA-IN-1 (compound 8) is an N-acetyl-derived LANA inhibitor with antiviral activity against herpesvirus. In fluorescence assays using the LANA probe LBS2, 1 mM LANA-IN-1 shows an inhibition rate of 32%. LANA-IN-1 may inhibit the interaction between LANA and the viral genome[1].

Synthesis

288-32-4

106-40-1

2221-00-3

GENERAL METHODS: In a catalyzed reaction, Catalyst C1 (12 mg, 0.01 mmol), imidazole (1.0 mmol), 4-bromoaniline (1.0 mmol), NaOH (80 mg, 2.0 mmol), and dimethyl sulfoxide (DMSO, 5 mL) were added to a sealed tube. The reaction mixture was stirred at 100 °C for 4 h and subsequently cooled to room temperature. After the reaction was completed, 5 mL of water was added and the mixture was extracted with ethyl acetate (5 mL x 3). The organic layers were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent. Finally, the target product 4-(imidazol-1-yl)aniline was purified by silica gel column chromatography.

References

[1] Kirsch P, et al. Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8. J Med Chem. 2019 Apr 25;62(8):3924-3939. DOI:10.1021/acs.jmedchem.8b01827

4-(1H-Imidazol-1-yl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(1H-Imidazol-1-yl)aniline manufacturers

Career Henan Chemical Co

Product: 4-(1H-Imidazol-1-yl)aniline 2221-00-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-22

2221-00-3, 4-(1H-Imidazol-1-yl)anilineRelated Search:

N-Phenylglycinonitrile Aniline Acid Blue 93 Imidazole 4-(4,5-Dichloro-1H-imidazol-1-yl)aniline, 95+%,4-(4,5-DICHLORO-1H-IMIDAZOL-1-YL)ANILINE BOC-HIS(DNP)-OH 1-(4-Nitrophenyl)-1H-imidazole 2-(1H-BENZO[D]IMIDAZOL-2-YL)ANILINE 4-(4-Methyl-1H-imidazol-1-yl)benzenamine 5-FLUORO-2-(1H-IMIDAZOL-1-YL)ANILINE 3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)benzenamine 3-(1h-imidazol-1-yl)aniline FMOC-HIS(DNP)-OH BIS(2,4-DINITROPHENYL)-L-HISTIDINE BOC-D-HIS(DNP)-OH IPOH 4,5-DICHLORO-1-(4-NITROPHENYL)IMIDAZOLE N-(4-(4,5-DICHLOROIMIDAZOLYL)PHENYL)(2-(4-CHLOROPHENOXY)(3-PYRIDYL))FORMAMIDE RO 15-4513

ART-CHEM-BB B021935

1-(4-AMINOPHENYL)IMIDAZOLE

1-(4'-AMINOPHEN-1-YL)IMIDAZOLE

1-(4-AMINOPHENYL)-1H-IMIDAZOLE

4-(IMIDAZOL-1-YL)-ANILINE

4-IMIDAZOL-1-YL-PHENYLAMINE

4-(1H-IMIDAZOL-1-YL)ANILINE

AKOS B021935

AKOS BBS-00000369

AKOS BB-8983

4-(1H-Imidazole-1-yl)aniline

4-imidazolyl-aniline

4-(Imidazol-1-yl)aniline, GC 97%

4-(1H-imidazol-1-yl)benzenamine

N-phenyl-1H-iMidazol-1-aMine

4-(1H-IMidazol-1-yl)aniline 98%

[4-(1H-imidazol-1-yl)phenyl]amine

4-(1H-imidazol-1-yl)phenylamine

4-(1-imidazolyl)aniline

4-(1h-imidazol-1-yl)aniline:1-(4-aminophenyl)-1h-IMIDAZOLE

benzenamine, 4-(1H-imidazol-1-yl)-

4-(1<i>H</i>-Imidazol-1-yl)aniline

LANA-IN-1

2221-00-3

Imidazoles

Heterocyclic Building Blocks

Building Blocks

Heterocyclic Compounds

Amines

Phenyls & Phenyl-Het

pharmacetical

Imidazol&Benzimidazole