ChemicalBook > CAS DataBase List > H-PRO-LEU-GLY-NH2

H-PRO-LEU-GLY-NH2

Product Name: H-PRO-LEU-GLY-NH2
CAS No.: 2002-44-0
Chemical Name: H-PRO-LEU-GLY-NH2
Synonyms: MELANOSTATIN;MIF-1;PRO-LEU-GLY-NH2;MIF-I;PLG-NH2;MSH-R-IF;MIF, AMIDE;Melanostatin I;H-PRO-LEU-GLY-NH2;PRO-LEU-GLY AMIDE
CBNumber: CB2779319
Molecular Formula: C13H24N4O3
Formula Weight: 284.35
MOL File: 2002-44-0.mol

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H-PRO-LEU-GLY-NH2 Property

Melting point:: 122-123 °C(Solv: water (7732-18-5))
Boiling point:: 626.2±55.0 °C(Predicted)
Density: 1.147±0.06 g/cm3(Predicted)
storage temp.: -15°C
solubility: ≥59.1 mg/mL in DMSO; ≥50 mg/mL in EtOH; ≥50 mg/mL in H2O
pka: 14.10±0.20(Predicted)
form: Lyophilized powder
Water Solubility: Soluble in water.
Sequence: H-Pro-Leu-Gly-NH2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1929
Product name: Melanocyte-stimulatinghormonereleaseinhibitingfactor
Packaging: 10
Price: $72
Updated: 2021/12/16

TRC

Product number: P756193
Product name: L-Prolyl-L-leucylglycinamide
Packaging: 25mg
Price: $65
Updated: 2021/12/16

Usbiological

Product number: 255779
Product name: Melanocyte-stimulating hormone release inhibiting factor
Packaging: 10mg
Price: $310
Updated: 2021/12/16

Usbiological

Product number: M2868-72R
Product name: Melanocyte Stimulating Hormone Release Inhibiting Factor
Packaging: 1mg
Price: $531
Updated: 2021/12/16

Usbiological

Product number: M2868-72S
Product name: Melanocyte Stimulating Hormone Release Inhibiting Factor
Packaging: 1mg
Price: $531
Updated: 2021/12/16

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H-PRO-LEU-GLY-NH2 Chemical Properties,Usage,Production

Uses

L-Prolyl-L-leucylglycinamide is shown to be effective in treating human depression with greater efficacy and faster onset of action than traditional anti-depressants.Also, it is used in the synthesis of novel analogs to be tested for their ability to enhance the binding of [3H]-N-propylnorapomorphine to short isoform of human dopamine D2 receptors.

Definition

ChEBI: Melanostatin is an oligopeptide.

Biological Activity

melanocyte stimulating hormone release inhibiting factor,(c13h24n4o3), a tri-peptide with the sequence h2n-pro-leu-gly-amide, mw= 284.35. melanocyte-inhibiting factor (also known as pro-leu-gly-nh2, melanostatin, msh release-inhibiting hormone or mif-1) is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body(1). mif-1 produces multiple effects, both blocking the effects of opioid receptor activation(2), while at the same time acting as a positive allosteric modulator of the d2 and d4 dopamine receptor subtypes, as well as inhibiting release of other neuropeptides such as alpha-msh, and potentiating melatonin activity(3). mif-1 is unusually resistant to metabolism in the bloodstream, and crosses the blood–brain barrier easily, though it is poorly active orally and is usually injected.figure1 formula of melanocyte stimulating hormone release inhibiting factor

in vivo

MIF-1 (Melanostatin, 1 mg/kg; i.p.; once, for 1 hour; male Wistar rats) modulates the analgesic effects and stress-induced analgesia (SIA)^[1].
MIF-1 (Melanostatin, 1 mg/kg; i.p.; daily, for 8 weeks; Sprague-Dawley rats) attenuates spiroperidol-induced impairment of development of striatal dopamine D2 receptors in rats^[3].

Animal Model:	Male Wistar rats^[1]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; once, for 1 hour
Result:	Decreased the analgesic effect. Increased the pain threshold for at least 1 h.

Animal Model:	Sprague-Dawley rats^[3]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; daily, for 8 weeks
Result:	Attenuated the ontogenic impairment of striatal D2 receptors that was produced by spiroperidol (HY-B1371) treatment.

storage

-20°C (desiccate)

References

1. Celis ME, Taleisnik S, Walter R (July 1971). "Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America 68 (7): 1428–33.2. Contreras PC, Takemori AE (June 1984). "Effect of prolyl-leucyl-glycinamide and alpha-melanocyte-stimulating hormone on levorphanol-induced analgesia, tolerance and dependence". Life Sciences 34 (26): 2559–66.3. Sandyk R (May 1990). "MIF-induced augmentation of melatonin functions: possible relevance to mechanisms of action of MIF-1 inmovement disorders". The International Journal of Neuroscience 52 (1-2): 59–65.

H-PRO-LEU-GLY-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from H-PRO-LEU-GLY-NH2 manufacturers

Dingwang Technology (Wuhan) Co., Ltd.

Product: MIF-1 (pro-Leu-Gly-NH2) 2002-44-0
Price: US $0.00/g
Min. Order: 1g
Purity: 99% min
Supply Ability: 20 tons
Release date: 2025-01-16

Shaanxi Dideu Medichem Co. Ltd

Product: H-PRO-LEU-GLY-NH2 2002-44-0
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-07-14

Career Henan Chemical Co

Product: H-PRO-LEU-GLY-NH2 2002-44-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-13

2002-44-0, H-PRO-LEU-GLY-NH2Related Search:

Carbetocin Oxytocin free acid Oxytocin Z-PRO-LEU-GLY-NH2 H-TYR-PRO-LEU-GLY-NH2,TYR-PRO-LEU-GLY-NH2 CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 ACETATE SALT BIOTIN-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2,BIOTIN-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 (DISULFIDE BRIDGE: 1-6) H-PRO-LEU-GLY-NH2 H2O,L-PRO-LEU-GLY NH2 HEMIHYDRATE CYCLO(TYR-ILE-GLN-ASN-ASU)-PRO-LEU-GLY-NH2,TYR-ILE-GLN-ASN-ASU-PRO-LEU-GLY-NH2 H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH-CH2CH2F N-(4-Oxo-4H-3,1-benzoxazin-2-yl)-Pro-Leu-Gly-NH2 PRO-LEU-GLY-NH2 1/2H2O Cys(Bzl)-Pro-Leu-Gly-NH2 Z–GLN–ASN–CYS(BZL)–PRO–LEU–GLY–NH2 H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH-CH2CH2F, (DISULFIDE BOND) BOC-ASN-CYS(ACM)-PRO-LEU-GLY-NH2 H2O OXYTOCIN = H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 DISULFIDE BOND CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 ACETATE SALT HYDRATE

MELANOCYTE STIMULATING HORMONE RELEASE INHIBITING FACTOR

MELANOCYTE STIMULATING HORMONE RELEASE INHIBITING FACTOR, AMIDE

MELANOCYTE STIMULATING HORMONE RELEASING FACTOR

MELANOSTATIN

H-PRO-LEU-GLY-NH2

L-Prolyl-L-leucylglycinamide, hemihydrate

L-prolyl-L-leucylglycinamide

MSH-RELEASE INHIBITING FACTOR

MSH RELEASE INHIBITING FACTOR, AMIDE

MIF-1

MIF, AMIDE

MIF-I

PRO-LEU-GLY AMIDE

PRO-LEU-GLY-NH2

PLG-NH2

MIF-I, Melanostatin, Melanotropin Release-Inhibiting Factor

Melanostatin, MIF-I, Oxytocin fragment 7-9

Melanocyte-stimulating hormone release inhibiting factor I

Melanocyte-stimulating hormone release-inhibiting factor I

Melanostatin I

MSH-release inhibiting factor I

PRO-LEU-GLY AMIDE;MIF-I;OXYTOCIN FRAGMENT 7-9

(2S)-N-[(1S)-1-[(2-amino-2-keto-ethyl)carbamoyl]-3-methyl-butyl]pyrrolidine-2-carboxamide

(2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

(2S)-N-[(2S)-1-[(2-azanyl-2-oxo-ethyl)amino]-4-methyl-1-oxo-pentan-2-yl]pyrrolidine-2-carboxamide

MIF-1;MSH-R-IF;MELANOCYTE-STIMULATING HORMONE RELEASE-INHIBITING FACTOR

MSH-R-IF

(S)-N-((S)-1-((2-Amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide

Glycinamide, L-prolyl-L-leucyl-

Melanocyte-stimulati

Oxytocin C-terminal tripeptide

Melanocyte-Stimulating Hormone-Release Inh,MSH Release Inhibiting Factor, amide

L-Prolyl-L-Leucyl-Glycinamide TFA salt

MIF-1 (pro-Leu-Gly-NH2)

2002-44-0

C13H24N4O3

Cytokines, Growth Factors and Hormones

Pituitary Hormones

Oxytocin

Hormones

Cell Signaling and Neuroscience

Cell Biology

BioChemical

SignalTransduction

Melanocortin receptor

peptide

Elisa Kit-Mouse Elisa Kit