RARECHEM AL BW 0442
- Product Name
- RARECHEM AL BW 0442
- CAS No.
- 56622-54-9
- Chemical Name
- RARECHEM AL BW 0442
- Synonyms
- RARECHEM AL BW 0442;UKRORGSYN-BB BBV-059064;6-Methyl-3-PyridineMethanaMine;3-AMinoMethyl-6-Methylpyridine;(6-Methyl-3-pyridyl)methanamine;5-(Aminomethyl)-2-methylpyridine;3-PYRIDINEMETHANAMINE, 6-METHYL-;(6-METHYLPYRIDIN-3-YL)METHANAMINE;1-(6-METHYLPYRIDIN-3-YL)METHANAMINE;1-(6-Methyl-3-pyridinyl)MethanaMine
- CBNumber
- CB2781947
- Molecular Formula
- C7H10N2
- Formula Weight
- 122.17
- MOL File
- 56622-54-9.mol
RARECHEM AL BW 0442 Property
- Melting point:
- 58-61 °C(Solv: heptane (142-82-5))
- Boiling point:
- 90-100 °C(Press: 4 Torr)
- Density
- 1.027±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- pK1: 8.70(+1) (30°C)
- Appearance
- White to yellow <58°C Solid,>61°C Liquid
Safety
- Hazard Codes
- T
- Risk Statements
- 25-37/38-41
- Safety Statements
- 26-39-45
- RIDADR
- UN2811
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A617015
- Product name
- 3-Aminomethyl-6-methylpyridine
- Packaging
- 100mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 160441
- Product name
- 3-Aminomethyl-6-methylpyridine
- Packaging
- 100mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- A617015
- Product name
- 3-Aminomethyl-6-methylpyridine
- Packaging
- 1g
- Price
- $745
- Updated
- 2021/12/16
- Product number
- A617015
- Product name
- 3-Aminomethyl-6-methylpyridine
- Packaging
- 10g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- 3H32-1-AD
- Product name
- 3-Aminomethyl-6-methylpyridine
- Packaging
- 250mg
- Price
- $149
- Updated
- 2021/12/16
RARECHEM AL BW 0442 Chemical Properties,Usage,Production
Uses
3-Aminomethyl-6-methylpyridine is used in the synthesis of non-nucleoside phthalimide derivatives as HIV-1 reverse transcriptase inhibitors. Also used in in the discovery of potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with cytocrhome P450 CYP2C9 inhibitory activity.
Synthesis
6960-22-1
56622-54-9
Example 4: 106 Synthesis of Step 1: Under argon protection, 3.00 g (22.0 mmol) of 6-methylnicotinamide was dissolved in 10 ml of tetrahydrofuran (THF), followed by the slow addition of 34 ml (34 mmol; 1.5 eq.) of 1 M lithium aluminium hydride in THF solution. After 45 min of reaction, 1.22 g (1.5 eq.) of lithium aluminum hydride dissolved in 40 ml of THF was added to the system. The reaction mixture was heated to 60°C under stirring and maintained at this temperature for 24 hours. Upon completion of the reaction, the reaction was carefully quenched sequentially with isopropanol, methanol and water at 0°C under stirring. Subsequently, the solvent was evaporated under reduced pressure. To the residue, 100 ml of 2N NaOH solution and 100 ml of dichloromethane (DCM) were added and centrifuged to separate the resulting white precipitate. The aqueous layer was extracted four times with 60 ml of DCM. All organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent to afford 1.57 g (12.9 mmol; 58% yield) of the target product, 3-aminomethyl-6-methylpyridine (amine 2), which was used directly in the subsequent reaction without further purification.
References
[1] Patent: WO2006/128670, 2006, A1. Location in patent: Page/Page column 113
RARECHEM AL BW 0442 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from RARECHEM AL BW 0442 manufacturers
- Product
- RARECHEM AL BW 0442 56622-54-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03