6-METHYLNICOTINAMIDE
- Product Name
- 6-METHYLNICOTINAMIDE
- CAS No.
- 6960-22-1
- Chemical Name
- 6-METHYLNICOTINAMIDE
- Synonyms
- 6-METHYLNICOTINAMIDE;6-MethyInicotinamide;Nicotinamide, 6-methyl-;6-Methylnicotinamide>Nicotinamide Impurity 6;6-Methylnicotinamide,98%;5-CARBOXAMIDO-2-PICOLINE;6-Methylnicotinamide 98%;Nicotinamide Impurity 141;6-Methylnicotinic Acid AMide
- CBNumber
- CB9220966
- Molecular Formula
- C7H8N2O
- Formula Weight
- 136.15
- MOL File
- 6960-22-1.mol
6-METHYLNICOTINAMIDE Property
- Melting point:
- 197-199 °C(lit.)
- Boiling point:
- 289.4±28.0 °C(Predicted)
- Density
- 1.157±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- water: soluble50mg/mL, clear to slightly hazy, colorless to light yellow
- form
- Solid
- pka
- 15.04±0.50(Predicted)
- color
- Plae Beige to Pale Orange
- Water Solubility
- water: soluble 50mg/mL, clear to slightly hazy, colorless to light yellow
- BRN
- 112050
- CAS DataBase Reference
- 6960-22-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 284769
- Product name
- 6-Methylpyridine-3-carboxamide
- Purity
- 98%
- Packaging
- 5g
- Price
- $108.5
- Updated
- 2025/07/31
- Product number
- M2477
- Product name
- 6-Methylnicotinamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $136
- Updated
- 2025/07/31
- Product number
- M2477
- Product name
- 6-Methylnicotinamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $474
- Updated
- 2025/07/31
- Product number
- M323225
- Product name
- 6-Methylnicotinamide
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- M323225
- Product name
- 6-Methylnicotinamide
- Packaging
- 2g
- Price
- $80
- Updated
- 2021/12/16
6-METHYLNICOTINAMIDE Chemical Properties,Usage,Production
Chemical Properties
White soild
Uses
A nicotinamide derivative that inhibits state 3 respiration in isolated rat liver mitochondria. It is toxic to rat B65 neuroblastoma cells and is used in studies associated with early symptoms of Parkinson''s disease.
Uses
6-Methylpyridine-3-carboxamide may be used in chemical synthesis studies.
Uses
6-Methylnicotinamide is a nicotinamide derivative that inhibits state 3 respiration in isolated rat liver mitochondria. It is toxic to rat B65 neuroblastoma cells and is used in studies associated with early symptoms of Parkinson's disease.
Synthesis
3222-47-7
6960-22-1
To a stirred dichloromethane (DCM) solution of 6-methylpyridine-3-carboxylic acid (0.3 g, 2 mmol) was added ammonium chloride (0.7 g, 13 mmol), triethylamine (TEA, 2.7 mL, 19 mmol), and propylphosphoric anhydride (T3P, 4 mL, 6.5 mmol) sequentially at 0 °C. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated sodium bicarbonate (NaHCO3) solution and the reaction mixture was extracted with dichloromethane (DCM). The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by Combiflash rapid chromatography system using 10% methanol (MeOH) in dichloromethane (DCM) solution as eluent to give white solid 6-methylnicotinamide (0.1 g, 33.6% yield). The product was confirmed by 1H NMR (DMSO-d6, 400 MHz): δ2.48 (s, 3H), 7.30 (d, J=8Hz, 1H), 7.44 (bs, 1H), 8.02 (bs, 1H), 8.07 (dd, J=2.4 Hz, J=2.4 Hz, 1H), 8.88 (s, 1H); mass spectra (ESI) m/z 137.1 ([M+H]+); HPLC analysis showed a purity of 98.97% at 264 nm.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 5, p. 922 - 925
[2] Journal of Chemical Research, Miniprint, 1987, # 9, p. 2360 - 2384
6-METHYLNICOTINAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-METHYLNICOTINAMIDE manufacturers
- Product
- 6-Methylnicotinamide 6960-22-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28
- Product
- 6-METHYLNICOTINAMIDE 6960-22-1
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-09-20
- Product
- 6-Methylnicotinamide 6960-22-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14